Publications

Jodelka, F.M., Ebert, A.D., Duelli, D.M., and Hastings, M.L. (2010) A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum. Mol. Genet.

Pigati, L., Yaddanapudi, S., Iyengar, R., Kim, D.J., Hearn, S., Danforth, D., Hastings M.L., Duelli, D.M. (2010) Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells. PLoS One. http://dx.plos.org/10.1371/journal.pone.0013515.

Salato, V.K., Rediske, N.W., Zhang, C., Hastings, M.L., and Munroe, S. H. (2010) An exonic splicing enhancer within a bidirectional coding sequence regulates splicing of thyroid hormone receptor mRNA. RNA Biology, 7: 179-90.

Hastings, M.L., Berniac, J., Liu, Y.H., Abato, P., Jodelka, F.M., Barthel, L., Kumar, S., Dudley, C., Larson, K., Edmonds, J., Bowser, T., Draper, M., Higgins, P., and Krainer, A.R. (2009) Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Science Translational Medicine 1: 5ra12.

Araujo, M., Bonnal, S., Hastings, M.L., Krainer, A.R. and Valcarcel, J. (2009) Differential 3’ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA 15: 515-523.

Hastings, M.L. and Sachidanandam, R. (2008) Evolutionary conservation of splice sites. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0020782.

Zhang, C., Hastings, M.L., Krainer, A.R. and Zhang, M.Q. (2007) Dual-specificity splice sites are used as both 5’ and 3’ splice sites. Proc. Natl. Acad. Sci. USA 104: 15028.

Hastings, M.L., Allemand, E., Duelli, D.M., Myers, M.P. and Krainer, A.R. (2007) Cooperation between PUF60 and U2AF65 determines pre-mRNA splicing efficiency and alternative splice-site choice. PLoS ONE 2: e538.

Allemand, E., Hastings, M.L., Murray, M.V., Myers, M.P. and Krainer, A.R. (2007) Alternative splicing regulation by interaction of phosphatase PP2Cg and nucleic acid-binding protein YB-1. Nature Struct. Mol. Biol. 14: 630-638.

Sheth, N., Roca, X., Hastings, M.L., Roeder, T., Krainer, A.R. and Sachidanandam, R. (2006) Comprehensive splice-site analysis using comparative genomics.  Nucleic Acids Res.34: 3955-3967.

Cartegni, L.*, Hastings, M.L.*, Calarco, J.A., de Stanchina, E. and Krainer, A.R. (2006) Determinants of exon 7 identity in the spinal muscular atrophy genes, SMN1 and SMN2. Am. J. Hum. Genet.  78: 63-77.
*equal contributors

Hastings, M.L., Resta, N., Traum, D., Stella, A., Guanti, G. and Krainer, A.R. (2005). An LKB1 AT-AC intron causes Peutz-Jeghers syndrome via splicing at non-canonical cryptic splice sites. Nature Struct. Mol. Biol. 12: 54-59

Hastings, M.L. and Krainer, A.R. (2001). Pre-mRNA splicing in the new millennium. Curr. Opin. Cell Biol. 13:302-309.

Hastings, M.L. and Krainer, A.R. (2001). Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA 7:471-482.

Hastings, M.L., Wilson, C.M. and Munroe, S.H. (2001). A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA 7:859-874.

Hastings, M.L., Ingle, H.A., Lazar, M.A. and Munroe, S.H. (2000). Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA.  J.  Biol. Chem. 275:11507-11513.

Hastings, M.L., Milcarek, C., Martincic, K., Peterson, M.L. and Munroe, S.H. (1997). Expression of the thyroid hormone receptor gene, erbAa, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels. Nucleic Acids Res. 25: 4296-4300.