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RESEARCH AND PUBLICATIONS:

Program Director: Ashok Fulambarker, MD

1. ABSTRACTS AND PUBLICATION 2004-2007
1. Farooki B, Fulambarker, A. Effect of YOGA exercises on COPD Outcomes. Accepted for presentation at the American Thoracic Society Annual Meeting, San  Francisco, May 2007.


2. Rami Arfoosh, MD, Hosni Arwa, MD, Adra Fadi, MD, Mark Cohen PHD, Ashok Fulambarker, MD. FCCP.  Effect of Continuous Positive Airway Pressure Therapy on High Density Lipoprotein Cholesterol (HDLc) in Compliant and Noncompliant Patients with Obstructive Sleep Apnea


3. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions  of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005


4. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J.  Maldonado, F. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Chest. 128:392S, 2005


5. Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Cardiac Tamponade as a rare Primary Presentation of Sarcoidosis. Chest. 128: 464S, 2005


6. Fulambarker, A. Copur, AS. Javeri, A. Jere, S.  Cohen M. Reference Values for Pulmonary  Function in Asian Indians Living in the United States.  Chest. 126, 1225-1233, 2004.


7. Rashid, Ahmad M. Fulambarker, A. Cohen, M. Patel, B. Sood,V. Effects of Systemic Corticosteroids on     Mechanically Ventilated Patients with Acute Exacerbation of COPD. Chest  126:805-806, 2004


8. Sethi, S. Fogarty, C. Fulambarker, A. A Randomized, Double-Blind study comparing Oral Gemifloxacin with 7 days Oral Levofloxacin in patients with Acute Exacerbation of Chronic Bronchitis. Respiratory Medicine. 98, 697-707, 2004


9. Tillotson, G. Fulambarker, A. 5 days oral Gemifloxacin with 7 days oral Levofloxacin in the treatment of acute exacerbation of Chronic Bronchitis., Chest, 126: 839S, 2004



10. Fulambarker, A. Vinu, T. Cohen, M. Thottupuram, K.     Rosman, J. Shenoy, A. Copur, AS.         
    Comparison of Pulmonary Function in Immigrant versus U.S. Born Asian Indians.  Am J of Respir Critical Care Med.  167, A421, 2003.


11. Istanbouly, E Gluck, A Fulambarker, P Sheridan, M Muammar. The Effect of Air Pollution and Pollen on Emergency Room Visits for Asthma Exacerbation in both Urban and Suburban Hospitals in the Chicago Area.  Am J of Respir Critical Care Med. 167, A334, 2003. 



12. Inactivated Influenza Virus Vaccine (TVV) in Adults with Chronic Obstructive Pulmonary  Disease (COPD): A VA Cooperative Study.  GJ Gorse, TG O’Connor, SL Young, A Fulambarker. Vaccine 21; 2133-2144, 2003


2. CURRENT RESEARCH PROJECTS:


1. Effect of YOGA Exercises on COPD Outcomes. B. Farroki , Rami Arfoosh, MD, Hosni Arwa, MD, Adra Fadi, MD, Mark Cohen PHD, Ashok Fulambarker, MD, FCCP. 


2. Effect of Continuous Positive Airway Pressure Therapy on High Density Lipoprotein Cholesterol (HDLc) in Compliant and Noncompliant Patients with Obstructive Sleep Apnea, Ashok Fulambarker, MD, FCCP.


3. Comparison of Pulmonary Function in Immigrant Versus U.S. Born Asian Indians. A Fulambarker, A Copur, M Cohen. 2003-2006.


4. Role of Empiric Treatment with Auto-titrating CPAP in Patients with Suspected Sleep apnea. Sunita Kumar, A Fulambarker, Ahmad rashid 2005-2006


5. Determining Clinical Markers to Predict Obstructive sleep apnea to Improve Access Polysomnography in a Veterans Hospital. Sunita Kumar, A Fulambarker, S. Sripathi 2005-06


6. Efficacy of Inhaled Tobramycin in Moderate to Severe COPD patients colonized with Pseudomonas Aeruginosa. N Akkina, A Fulambarker 2006-07


7. Effect of YOGA on COPD Outcomes: A pilot Study. B. Farooki, A Fulambarker. 2006-07


8. Effect of Using Spirometry on Smoking Cessation Rate. Lavanya Srinivasan, Rami Arfoosh, A Fulambarker, M. Cohen. 2006-07


9. Effect of CPAP on High Density Lipoprotein Cholesterol in Obstructive Sleep Apnea. Rami Arfoosh, Lavanya Srinivasan, Sunita Kumar, A Fulambarker


10. A 12 Month Double Dummy Randomized, Parallel Group, Multicenter Efficacy and Safety Study of SYMBICORTA® pMDI 2x160/4.5 ug bid . A Fulambarker, Sunita kumar
    2005-06

Abstracts and Publications of Raúl J. Gazmuri, MD, PhD  (2003-2006):

Abstracts

1. Kolarova JD, Ayoub IM, Sehgal MA, Gazmuri RJ. Delaying start of resuscitation to allow NHE-1 Inhibition before reperfusion compromises outcome. Circulation 2003;108:IV-1035.
2. Ayoub IM, Kolarova JD, Sehgal MA, Sanders R, Sheth O, Gazmuri RJ. Sodium-hydrogen exchange inhibition minimizes adverse effects of epinephrine during cardiac resuscitation. Circulation 2003;108:IV-420.
3. Sehgal MA, Kolarova JD, Ayoub IM, Sheth O, Gazmuri RJ. Reverse mode inhibition of the Na+-Ca2+ exchanger protects the myocardium during resuscitation from ventricular fibrillation. Circulation 2003;108:IV-380.
4. Gopalakrishnan PP, Ayoub IM, Kolarova JD, Sehgal MA, Gazmuri RJ. Dynamic obstruction to forward blood flow may explain instances of ineffective closed-chest resuscitation. Circulation 2003;108:IV-1037.
5. Kolarova JD, Ayoub IM, Hoda ZA, Sehgal MA, Gazmuri RJ. NHE-1 inhibition improves the depth/flow relationship of chest compression. Crit Care Med 2003;31:A10.
6. Ayoub IM, Kolarova JD, Gazmuri RJ. NHE-1 inhibition during hemorrhagic shock preserves myocardial function. Crit Care Med 2003;31:A29.
7. Ayoub IM, Kolarova JD, Gazmuri RJ. Hyperlactatemia in swine after stable surgical preparation. Crit Care Med 2003;31:A31.
8. Ayoub IM, Kolarova JD, Kantola R, Sanders R, Sheth O, Gazmuri RJ. Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation. Circulation 2004;110:III-531.
9. Kolarova JD, Ayoub IM, Hoda ZA, Gazmuri RJ. Cariporide decreases the depth of chest compression required to maximize forward blood flow. Circulation 2004;110:III-531.
10. Kolarova JD, Radhakrishnan J, Wang S, Gopalakrishnan P, Ayoub IM, Gazmuri RJ. Effects of cariporide on myocardial energy metabolism during resuscitation from VF. Circulation 2004;110:III-532.
11. Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. NHE-1 Inhibition and Coronary Blood Flow during VF are both Determinant of Post-Resuscitation Myocardial Dysfunction. (ReSS at the AHA 2004 meeting).
12. Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. Zoniporide ameliorates post-resuscitation myocardial dysfunction by flow independent mechanisms. Crit Care Med 2004;32:A57.
13. Sanders RW, Ayoub IM, Kolarova JD, Gazmuri RJ. Possible neuroprotective effects of zoniporide during resuscitation from cardiac arrest. Crit Care Med 2004;32:A57.
14. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Zoniporide ameliorates intramyocardial lactate increases during resuscitation from ventricular fibrillation. Crit Care Med 2004;32:A57.
15. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Progressive increases in plasma cytochrome c after resuscitation from ventricular fibrillation. Circulation 2005;112:II-324.
16. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Myocardial caspase-3 activation after resuscitation from ventricular fibrillation. Circulation 2005;112:II-324.
17. Ayoub IM, Kolarova JD, Kantola R, Radhakrishnan J, Wang S, Gazmuri RJ. NHE-1 inhibition prevents ischemic contracture and minimizes post-resuscitation myocardial dysfunction through flow-independent mechanisms. Circulation 2005;112:II-488.
18. Kolarova JD, Staicu I, Ayoub IM, Gazmuri RJ. NHE-1 inhibition delays onset of ischemic contracture during untreated ventricular fibrillation. Circulation 2005;112:II-1101.
19. Wang S, Kolarova JD, Radhakrishnan J, Ayoub IM, Gazmuri RJ. Cariporide attenuates intramyocardial Na+ increases during resuscitation from ventricular fibrillation. Circulation 2005;112:II-434.
20. Ayoub IM, Wang S, Kolarova JD, Radhakrishnan J, Singh D, Taglieri DM, Gazmuri RJ. Decreased ventilatory requirements during cardiac resuscitation. Circulation 2005;112:II-433.
21. Singh D, Ayoub IM, Kolarova JD, Wang S, Havalad S, Gazmuri RJ. Cardioprotection by erythropoietin during resuscitation from ventricular fibrillation. Crit Care Med 2005;33:A24.
22. Ayoub IM, Wang S, Radhakrishnan J, Kolarova JD, Lyu T, Ryan C, Gazmuri RJ. Cytochrome c: a novel biomarker for predicting survival after cardiac resuscitation. Crit Care Med 2005;33:A24.
23. Wang S, Radhakrishnan J, Ayoub IM, Kolarova JD, Taglieri DM, Gazmuri RJ. Post-resuscitation mitochondrial Ca2+ overload is prevented by limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation. Circulation 2006 (In Press).
24. Radhakrishnan J, Ayoub IM, Wang S, Kolarova JD, Taglieri DM, Gazmuri RJ. Myocardial protection by glycogen synthase kinase-3β inhibition during resuscitation from cardiac arrest. Circulation 2006 (In Press).
25. Radhakrishnan J, Ayoub IM, Wang S, Kolarova JD, Taglieri DM, Gazmuri RJ. Activation of the mitochondrial apoptotic pathway without evidence of apoptotic cell death after resuscitation from ventricular fibrillation. Circulation 2006 (In Press).
26. Kolarova JD, Ayoub IM, Wang S, Radhakrishnan J, Taglieri DM, Gazmuri RJ. AVE4454 (a new NHE-1 inhibitor) administered during resuscitation from VF ameliorates post-resuscitation myocardial dysfunction. Circulation 2006 (In Press).
27. Taglieri DM, Ayoub IM, Kolarova JD, Wang S, Radhakrishnan J, Gazmuri RJ. Early administration of epinephrine during closed-chest resuscitation fails to improve return of spontaneous circulation or short-term survival. Circulation 2006 (In Press).
28. Taglieri DM, Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. Failure of propranolol and epinephrine combination to improve resuscitability and short-term survival in a rat model of ventricular fibrillation. Circulation 2006 (In Press).

Peer Reviewed Articles

1. Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ. Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 2003;107:1804-9.
2. Kolarova J, Ayoub IM, Yi Z, Gazmuri RJ. Optimal timing for electrical defibrillation after prolonged untreated ventricular fibrillation. Crit Care Med 2003;31:2022-8.
3. Kolarova J, Yi Z, Ayoub IM, Gazmuri RJ. Cariporide potentiates the effects of epinephrine and vasopressin by non-vascular mechanisms during closed-chest resuscitation. Chest 2005;127:1327-34.
4. Kolarova JD, Ayoub IM, Gazmuri RJ. Cariporide enables hemodynamically more effective chest compression by leftward shift of the flow-depth relationship. Am J Physiol Heart Circ Physiol 2005;288:H2904-11.
5. Ayoub IM, Kolarova J, Kantola RL, Sanders R, Gazmuri RJ. Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation. Crit Care Med 2005 33:2599-605.

Book Chapters

1. Gazmuri RJ, Ayoub IM. Myocardial Effects of Sodium-Hydrogen Exchange Inhibition during Resuscitation from Ventricular Fibrillation. In: Dhalla NS, Takeda N, Singh M, and Lukas A (eds). Myocardial Ischemia and Preconditioning. Boston: Kluwer Academic Publishers, 2003, pp.375-388.
2. Gazmuri RJ, Ayoub IM. NHE-1 Inhibition: A Potential New Form of Treatment for Resuscitation from Cardiac Arrest. In: Karmazyn M, Avkiran M, Fliegel L (Ed). The Sodium-Hydrogen Exchanger. From Molecule to its Role in Disease. Kluwer Academic Publishers, 2003, pp.291-308.
3. Gazmuri RJ, Ayoub IM. Kolarova J. Inhibition of the Sodium-Hydrogen Exchanger: A Potential Treatment for Resuscitation from Cardiac Arrest. In: Vincent JL (ed). 2003 Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag, 2003, pp.461-471.
4. Gazmuri RJ, Gopalakrishnan P. Ventricular Arrhythmias. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.783-794.
5. Gazmuri RJ, Vidyarthi V. Cardioversion and Defibrillation. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.1807-1815.
6. Gazmuri RJ, Ayoub IM. Transvenous and Transcutaneous Pacing. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.1817-1824.
7. Gazmuri RJ, Weil MH, Kern K, Tang W, Ayoub IM, Kolarova JD, Radhakrishnan J. Prevention and Therapy of Postresuscitation Myocardial Dysfunction. In: Paradis N, Halperin H, Kern K, Wenzel V, Chamberlain D (eds). Cardiac Arrest - The Science and Practice of Resuscitation Medicine, 2nd Edition. Cambridge University Press (In Press)

Editorials and Commentaries

1. Gazmuri RJ, Kube E.  Capnography during cardiac resuscitation:  A clue on mechanisms and a guide to interventions.  Critical Care 2003;7:411-412.
2. Gazmuri RJ, Gopalakrishnan P.  Hypothermia:  Cooling down inflammation.  Crit Care Med 2003;31:2811-2812.
3. Gazmuri RJ.  Editorial:  Optimizando la calidad en medicina intensiva [Optimizing the quality of intensive care medicine].  Rev Chil Med Intensiva 2004;19:53-54.
4. Gazmuri RJ, Ayoub IM.  B-type natriuretic peptide for predicting outcomes after open heart surgery:  Superior than traditional scoring systems?  Crit Care Med 2005;33:459-460.
5. Gazmuri, RJ, Kolarova JD, Ayoub IM.  Inotropic options for post-resuscitation myocardial dysfunction.  Crit Care Med 2005;33:668-670.

Abstracts and Publications, and Recent Research of Frank Maldonado, MD. (2002-2006):

1. 2003  Ayoub IM, Kolarova J, Yi Z, Trivedi A, Deshmukh H, Lubell DL, Franz MR,     Maldonado FA, Gazmuri RJ.  Sodium-hydrogen exchange inhibition during ventricular fibrillation:  Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability.  Circulation 2003; 107:1804-9.

1. 2003-2005    Efficacy and Safety of Inhaled Human Insulin (Exubera®) Compared with Subcutaneous Human Insulin in the Therapy of Adult Subjects with Type 1 or Type 2 Diabetes Mellitus and Chronic Obstructive Pulmonary Disease:  A One-Year, Multicenter, Randomized, Outpatient, Open-Label, Parallel-Group Comparative Trial.  Protocol Number  A2171030

Sponsor:  Pfizer/Aventis

Role:  Co-Principal Investigator

2003-ongoing  Improving Antibiotic Use in Acute Care Treatment
The IMPAACT Project
Sponsor:  VA and AHRQ
Role:  Principal Investigator

Absracts and Publications of Dr. Ahmet Sinan Copur

1. HIV is a risk factor for venous thromboembolism under age 50.
   Copur AS, Smith PR, Victor Gomez, Michael Bergman
   Pulmonary Division of Long Island College Hospital/Brooklyn NY
   AIDS PATIENT CARE and STD 16:5:205-209, 2002
2. Resting Energy Expenditure in Patients with Pressure Sores:  
   Measured vs Estimated.
   Fulambarker A, Copur AS, Chandok S.
   North Chicago VA Medical Center Pulmonary Division.
   Am J Respir Crit Care, March 1998;157 (3):A838.
   (presented as a poster in “1998 International Conference of 
   American Thoracic Society in Chicago, IL)
3. Reference values for pulmonary function in Asian Indians living in
   the United States.
   Fulambarker A, Copur AS, Javeri A, Jere S, Cohen ME
   Pulmonary Division, Chicago Medical School/Rosalind Franklin
   University Chest. 2004 Oct;126(4):1225-33
4. US born Asian Indians have higher pulmonary volumes compared 
   to immigrant Asian Indians
   Copur AS, Fulambarker A, Cohen ME, Patel M, Sanjay Gill
   Chest. 128:392S, 2005
5. Investigation of Attitudes toward Asthma and Self Management 
   Strategies among Patients with Poor Income.
   McDermott M, Melman S, Rydman R, Copur AS.
   Cook County Hospital Emergency Department.
   Presented in SAEM meeting in 1998.
6. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S.   
   Independent Contributions of Chronic Obstructive Pulmonary
   Disease and Abdominal Aortic Aneurysm to Mortality Risk. 
   Chest. 128:265S, 2005

Abstract and Publications of Joseph Rosman, MD:

1. Comparison of Pulmonary Function in Immigrant versus U.S. Born Asian Indians. A Fulambarker, T Vinu, M Cohen, K Thottupuram, J Rosman, A Shenoy. Am J of Respir Crit Care Med. 2003. 167, A421.
   
2. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J. Maldonado, F. Chest. 128:392S, 2005
   
3. Cardiac Tamponade as a rare Primary presentation of Sarcoidosis Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Chest. 128: 464S, 2005

Abstracts and Publications and Current Research Projects of Sunita Kumar, MD.
           

1. Efficacy of empiric use of Auto-titrating CPAP in patients suspected of having obstructive sleep apnea (accepted as abstract for APSS 2006) Sunita Kumar, M.D.; Saroja Sripathi, M.D., Ashok Fulambarker, M.D. , Ahmad Rashid, M.D. North Chicago VA Medical Center, North Chicago, IL


2. Determining clinical markers to predict obstructive sleep apnea to improve access to polysomnography in a Veterans hospital.(Accepted as abstract for APSS
   2006)Authors: Saroja Sripathi M.D.; Sunita Kumar M.D.; Ashok Fulambarker M.D.
   North Chicago VA Medical Center and Rosalind Franklin University of Science and Medicine, North Chicago, IL


3.  The effect of treating obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) on low HDL (High density cholesterol) and the correlation with insulin resistance. Rami Arfoosh, M.D.; Sunita Kumar, M.D.; Ashok Fulambarker, M.D. North Chicago VA Medical Center and Rosalind Franklin University of Science and Medicine, North Chicago, IL


4. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005

Publications of Robert J. Bridges, PhD

1. Silvis, M.R., Picciano, J.A., Bertrand, C., Weixel, K., Bridges, R.J. and Bradbury, N.A.  (2003).  A mutation in the cystic fibrosis transmembrane conductance regulator generates a novel internalization sequence and enhances endocytic rates.  J. Biol. Chem. 278:11554-11560.


2. Bertrand, C.A., Laboisse, C., Hopfer, U., Danahay, H., Poll, C.T. and Bridges, R.J.  (2004).  Niflumic acid inhibits ATP-stimulated mucin exocytosis through a calcium dependent mechanism.  Am. J. Physiol. 286:C247-255.


3. Singh, A.K., Schultz, B.D., van Driessche, W., Bridges, R.J.  (2004).  Transepithelial fluctuation analysis of chloride secretion.  J. Cyst. Fibros. Suppl 2:127-132.


4. Kreindler, J.L., Jackson, A., Kemp, P., Bridges, R.J., and Danahay, H.  (2005). Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract.  Am. J. Physiol. Lung Cell Mol. Physiol.  288(5):L894-L902.


5. Adebamiro, A., Cheng, Y., Johnson, J.P., and Bridges, R.J.  (2005) Endogenous protease activation of ENaC: Effect of serine protease inhibition on ENaC single channel properties.  J. Gen. Physiol. 126(4):339-52.


6. Danahay, H., Atherton, H.C., Jackson, A.D., Kreindler, J.L., Poll, C.T. and Bridges, R.J.  (2006). Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium.  Am. J. Physiol. Lung Cell Mol. Physiol. 290:L588-L569.


7. Bertrand, C.A., Laboisse, C., Hopfer, U., Bridges, R.J. and Frizzell, R.A.  (2006). Methods for detecting internalized, FM 1-43 stained particles in epithelial cells reveal cell density-dependent membrane trafficking.  Biophysical Journal (in Press).

Publications of Mark Cohen, PhD

1. Stone, M. E., Cohen, M. E., Debban, B. A.  Mercury vapor levels in exhaust air from dental vacuum systems.  Dental Materials, in press.


2. Radel, R. T., Goodell, G.G., McClanahan, S. B., Cohen, M.E.  In Vitro radiographic Determination of distances from working length files to root ends comparing Kodak RVG 6000, Schick CDR and Kodak InSight Film. Journal of Endodontics, 2006, 32, 566-568.


3. Stone, M. E., Kuehne, J. C., Cohen, M. E., Talbott, J. L., Scott J. W.  Effect of iodine on mercury concentrations in dental unit wastewater.  Dental Materials, 2006, 22, 119-124.


4. Tiba, A., Charlton, D.G., Vandewalle, K.S., and Cohen, M. E.  Volumetric polymerization shrinkage under simulated intraoral temperature and humidity conditions.  Operative Dentistry, 2005, 30-6, 696-701.


5. Cohen M. E., Debban, B. A., Cohen, M. E. and Kuehne, J. C.  Hg levels in exhaust air from dental vacuum systems.  Journal of Dental Research 85, Special Issue A:  Abstract #0036, 2006.


6. Lvovsky D., Fulambarker, A., Cohen, M., Copur, A.S., and Kumar, S.  Independent contributions of chronic obstructive pulmonary disease and abdominal aortic aneurysm to mortality risk.  Chest, 128:265S, 2005.


7. Copur, A. S., Fulambarker, A. Cohen, M., Patel, M., Gill, S., George, C., Rosman, J., and Maldonado, F.  U.S. born Asian Indians have higher pulmonary function values compared to immigrant Asian Indians, Chest, 128:392S, 2005.


8. Stone, M. E., Cohen, M., and Kuehne, J. C.  Evaluation of low cost chairside filters as amalgam separators.  Journal of Dental Research 84, Special Issue A:  Abstract #2696, 2005.


9. Stone, M. E., Kuehne, J. C., and Cohen, M.  Mercuric iodide complexes in dental-unit wastewater.  Journal of Dental Research 84, Special Issue A:  Abstract #2697, 2005.

Past fellows publications (2004-2006)

1. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005


2. Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Cardiac Tamponade as a rare Primary presentation of Sarcoidosis. Chest. 128: 464S, 2005


3. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J. Maldonado, F. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Chest. 128:392S, 2005


4. Copur, AS. Javeri, Fulambarker, A. Jere, S.  Cohen M. Reference Values for Pulmonary Function in Asian Indians Living in the United States.  Chest. 126, 1225-1233, 2004.


5. Rashid, Ahmad M. Fulambarker, A. Cohen, M. Patel, B. Sood,V. Effects of Systemic Corticosteroids on Mechanically Ventilated Patients with Acute Exacerbation of COPD. Chest  126:805-806, 2004

Fellows’ Research Projects (2003-2006):
These projects are either completed with publications as above or still in progress. These projects will be completed and published. The cycling time from the inception of a research project and publication sometimes far exceeds the fellow’s two year training in the program.

1. Comparison of Pulmonary Function in Immigrant Versus U.S. Born Asian Indians. A Fulambarker, A. Copur, M Cohen. 2003-2006.
2. Role of Empiric Treatment with Auto-titrating CPAP in Patients with Suspected Sleep apnea. Sunita Kumar, A Fulambarker, Ahmad rashid 2005-2006
3. Determining Clinical Markers to Predict Obstructive sleep apnea to Improve Access Polysomnography in a Veterans Hospital. Sunita Kumar, A Fulambarker, S. Sripathi 2005-06
4. Efficacy of Inhaled Tobramycin in Moderate to Severe COPD patients colonized with Pseudomonas Aeruginosa. N Akkina, A Fulambarker 2006-07
5. Effect of YOGA on COPD Outcomes: A pilot Study. B. Farooki, A Fulambarker. 2006-07
6. Effect of Using Spirometry on Smoking Cessation Rate. Lavanya Srinivasan, Rami Arfoosh, A Fulambarker, M. Cohen. 2006-07
7. Effect of CPAP on High Density Lipoprotein Cholesterol in Obstructive Sleep Apnea. Rami Arfoosh, Sunita Kumar, A Fulambarker
8. Effect of Various Candidate Compounds on CFTR Mediated Ion Transport”. Swamy Nagubadi, MD, Robert Bridges, PhD

Current Fellows' Research Project:

1. Effect of Long Term Oxygen Therapy on Inflammation in COPD patients
Saroja Sripathi, Ahmet Copur, Ashok Fulambarker

2. Smoking Cessation and Spirometry
Lavanya Srinivasan, Rami Arfoosh, Ashok Fulambarker MD, Mark Cohen

3. Incidence of Sleep Disorders in Mild TBI
Srikanth Davuluri, Ashok Fulambarker

4. Effect of CPAP on Urinary Albumin Excretion
Mohamad Al-Massalkhi, Ahmet Copur, Ashok Fulambarker

RESEARCH AND PUBLICATIONS:

Program Director: Ashok Fulambarker, MD

1. ABSTRACTS AND PUBLICATION 2004-2007
1. Farooki B, Fulambarker, A. Effect of YOGA exercises on COPD Outcomes. Accepted for presentation at the American Thoracic Society Annual Meeting, San  Francisco, May 2007.


2. Rami Arfoosh, MD, Hosni Arwa, MD, Adra Fadi, MD, Mark Cohen PHD, Ashok Fulambarker, MD. FCCP.  Effect of Continuous Positive Airway Pressure Therapy on High Density Lipoprotein Cholesterol (HDLc) in Compliant and Noncompliant Patients with Obstructive Sleep Apnea


3. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions  of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005


4. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J.  Maldonado, F. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Chest. 128:392S, 2005


5. Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Cardiac Tamponade as a rare Primary Presentation of Sarcoidosis. Chest. 128: 464S, 2005


6. Fulambarker, A. Copur, AS. Javeri, A. Jere, S.  Cohen M. Reference Values for Pulmonary  Function in Asian Indians Living in the United States.  Chest. 126, 1225-1233, 2004.


7. Rashid, Ahmad M. Fulambarker, A. Cohen, M. Patel, B. Sood,V. Effects of Systemic Corticosteroids on     Mechanically Ventilated Patients with Acute Exacerbation of COPD. Chest  126:805-806, 2004


8. Sethi, S. Fogarty, C. Fulambarker, A. A Randomized, Double-Blind study comparing Oral Gemifloxacin with 7 days Oral Levofloxacin in patients with Acute Exacerbation of Chronic Bronchitis. Respiratory Medicine. 98, 697-707, 2004


9. Tillotson, G. Fulambarker, A. 5 days oral Gemifloxacin with 7 days oral Levofloxacin in the treatment of acute exacerbation of Chronic Bronchitis., Chest, 126: 839S, 2004



10. Fulambarker, A. Vinu, T. Cohen, M. Thottupuram, K.     Rosman, J. Shenoy, A. Copur, AS.         
    Comparison of Pulmonary Function in Immigrant versus U.S. Born Asian Indians.  Am J of Respir Critical Care Med.  167, A421, 2003.


11. Istanbouly, E Gluck, A Fulambarker, P Sheridan, M Muammar. The Effect of Air Pollution and Pollen on Emergency Room Visits for Asthma Exacerbation in both Urban and Suburban Hospitals in the Chicago Area.  Am J of Respir Critical Care Med. 167, A334, 2003. 



12. Inactivated Influenza Virus Vaccine (TVV) in Adults with Chronic Obstructive Pulmonary  Disease (COPD): A VA Cooperative Study.  GJ Gorse, TG O’Connor, SL Young, A Fulambarker. Vaccine 21; 2133-2144, 2003


2. CURRENT RESEARCH PROJECTS:


1. Effect of YOGA Exercises on COPD Outcomes. B. Farroki , Rami Arfoosh, MD, Hosni Arwa, MD, Adra Fadi, MD, Mark Cohen PHD, Ashok Fulambarker, MD, FCCP. 


2. Effect of Continuous Positive Airway Pressure Therapy on High Density Lipoprotein Cholesterol (HDLc) in Compliant and Noncompliant Patients with Obstructive Sleep Apnea, Ashok Fulambarker, MD, FCCP.


3. Comparison of Pulmonary Function in Immigrant Versus U.S. Born Asian Indians. A Fulambarker, A Copur, M Cohen. 2003-2006.


4. Role of Empiric Treatment with Auto-titrating CPAP in Patients with Suspected Sleep apnea. Sunita Kumar, A Fulambarker, Ahmad rashid 2005-2006


5. Determining Clinical Markers to Predict Obstructive sleep apnea to Improve Access Polysomnography in a Veterans Hospital. Sunita Kumar, A Fulambarker, S. Sripathi 2005-06


6. Efficacy of Inhaled Tobramycin in Moderate to Severe COPD patients colonized with Pseudomonas Aeruginosa. N Akkina, A Fulambarker 2006-07


7. Effect of YOGA on COPD Outcomes: A pilot Study. B. Farooki, A Fulambarker. 2006-07


8. Effect of Using Spirometry on Smoking Cessation Rate. Lavanya Srinivasan, Rami Arfoosh, A Fulambarker, M. Cohen. 2006-07


9. Effect of CPAP on High Density Lipoprotein Cholesterol in Obstructive Sleep Apnea. Rami Arfoosh, Lavanya Srinivasan, Sunita Kumar, A Fulambarker


10. A 12 Month Double Dummy Randomized, Parallel Group, Multicenter Efficacy and Safety Study of SYMBICORTA® pMDI 2x160/4.5 ug bid . A Fulambarker, Sunita kumar
    2005-06

Abstracts and Publications of Raúl J. Gazmuri, MD, PhD  (2003-2006):

Abstracts

1. Kolarova JD, Ayoub IM, Sehgal MA, Gazmuri RJ. Delaying start of resuscitation to allow NHE-1 Inhibition before reperfusion compromises outcome. Circulation 2003;108:IV-1035.
2. Ayoub IM, Kolarova JD, Sehgal MA, Sanders R, Sheth O, Gazmuri RJ. Sodium-hydrogen exchange inhibition minimizes adverse effects of epinephrine during cardiac resuscitation. Circulation 2003;108:IV-420.
3. Sehgal MA, Kolarova JD, Ayoub IM, Sheth O, Gazmuri RJ. Reverse mode inhibition of the Na+-Ca2+ exchanger protects the myocardium during resuscitation from ventricular fibrillation. Circulation 2003;108:IV-380.
4. Gopalakrishnan PP, Ayoub IM, Kolarova JD, Sehgal MA, Gazmuri RJ. Dynamic obstruction to forward blood flow may explain instances of ineffective closed-chest resuscitation. Circulation 2003;108:IV-1037.
5. Kolarova JD, Ayoub IM, Hoda ZA, Sehgal MA, Gazmuri RJ. NHE-1 inhibition improves the depth/flow relationship of chest compression. Crit Care Med 2003;31:A10.
6. Ayoub IM, Kolarova JD, Gazmuri RJ. NHE-1 inhibition during hemorrhagic shock preserves myocardial function. Crit Care Med 2003;31:A29.
7. Ayoub IM, Kolarova JD, Gazmuri RJ. Hyperlactatemia in swine after stable surgical preparation. Crit Care Med 2003;31:A31.
8. Ayoub IM, Kolarova JD, Kantola R, Sanders R, Sheth O, Gazmuri RJ. Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation. Circulation 2004;110:III-531.
9. Kolarova JD, Ayoub IM, Hoda ZA, Gazmuri RJ. Cariporide decreases the depth of chest compression required to maximize forward blood flow. Circulation 2004;110:III-531.
10. Kolarova JD, Radhakrishnan J, Wang S, Gopalakrishnan P, Ayoub IM, Gazmuri RJ. Effects of cariporide on myocardial energy metabolism during resuscitation from VF. Circulation 2004;110:III-532.
11. Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. NHE-1 Inhibition and Coronary Blood Flow during VF are both Determinant of Post-Resuscitation Myocardial Dysfunction. (ReSS at the AHA 2004 meeting).
12. Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. Zoniporide ameliorates post-resuscitation myocardial dysfunction by flow independent mechanisms. Crit Care Med 2004;32:A57.
13. Sanders RW, Ayoub IM, Kolarova JD, Gazmuri RJ. Possible neuroprotective effects of zoniporide during resuscitation from cardiac arrest. Crit Care Med 2004;32:A57.
14. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Zoniporide ameliorates intramyocardial lactate increases during resuscitation from ventricular fibrillation. Crit Care Med 2004;32:A57.
15. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Progressive increases in plasma cytochrome c after resuscitation from ventricular fibrillation. Circulation 2005;112:II-324.
16. Radhakrishnan J, Wang S, Ayoub IM, Kolarova JD, Gazmuri RJ. Myocardial caspase-3 activation after resuscitation from ventricular fibrillation. Circulation 2005;112:II-324.
17. Ayoub IM, Kolarova JD, Kantola R, Radhakrishnan J, Wang S, Gazmuri RJ. NHE-1 inhibition prevents ischemic contracture and minimizes post-resuscitation myocardial dysfunction through flow-independent mechanisms. Circulation 2005;112:II-488.
18. Kolarova JD, Staicu I, Ayoub IM, Gazmuri RJ. NHE-1 inhibition delays onset of ischemic contracture during untreated ventricular fibrillation. Circulation 2005;112:II-1101.
19. Wang S, Kolarova JD, Radhakrishnan J, Ayoub IM, Gazmuri RJ. Cariporide attenuates intramyocardial Na+ increases during resuscitation from ventricular fibrillation. Circulation 2005;112:II-434.
20. Ayoub IM, Wang S, Kolarova JD, Radhakrishnan J, Singh D, Taglieri DM, Gazmuri RJ. Decreased ventilatory requirements during cardiac resuscitation. Circulation 2005;112:II-433.
21. Singh D, Ayoub IM, Kolarova JD, Wang S, Havalad S, Gazmuri RJ. Cardioprotection by erythropoietin during resuscitation from ventricular fibrillation. Crit Care Med 2005;33:A24.
22. Ayoub IM, Wang S, Radhakrishnan J, Kolarova JD, Lyu T, Ryan C, Gazmuri RJ. Cytochrome c: a novel biomarker for predicting survival after cardiac resuscitation. Crit Care Med 2005;33:A24.
23. Wang S, Radhakrishnan J, Ayoub IM, Kolarova JD, Taglieri DM, Gazmuri RJ. Post-resuscitation mitochondrial Ca2+ overload is prevented by limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation. Circulation 2006 (In Press).
24. Radhakrishnan J, Ayoub IM, Wang S, Kolarova JD, Taglieri DM, Gazmuri RJ. Myocardial protection by glycogen synthase kinase-3β inhibition during resuscitation from cardiac arrest. Circulation 2006 (In Press).
25. Radhakrishnan J, Ayoub IM, Wang S, Kolarova JD, Taglieri DM, Gazmuri RJ. Activation of the mitochondrial apoptotic pathway without evidence of apoptotic cell death after resuscitation from ventricular fibrillation. Circulation 2006 (In Press).
26. Kolarova JD, Ayoub IM, Wang S, Radhakrishnan J, Taglieri DM, Gazmuri RJ. AVE4454 (a new NHE-1 inhibitor) administered during resuscitation from VF ameliorates post-resuscitation myocardial dysfunction. Circulation 2006 (In Press).
27. Taglieri DM, Ayoub IM, Kolarova JD, Wang S, Radhakrishnan J, Gazmuri RJ. Early administration of epinephrine during closed-chest resuscitation fails to improve return of spontaneous circulation or short-term survival. Circulation 2006 (In Press).
28. Taglieri DM, Ayoub IM, Kolarova JD, Radhakrishnan J, Wang S, Gazmuri RJ. Failure of propranolol and epinephrine combination to improve resuscitability and short-term survival in a rat model of ventricular fibrillation. Circulation 2006 (In Press).

Peer Reviewed Articles

1. Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ. Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 2003;107:1804-9.
2. Kolarova J, Ayoub IM, Yi Z, Gazmuri RJ. Optimal timing for electrical defibrillation after prolonged untreated ventricular fibrillation. Crit Care Med 2003;31:2022-8.
3. Kolarova J, Yi Z, Ayoub IM, Gazmuri RJ. Cariporide potentiates the effects of epinephrine and vasopressin by non-vascular mechanisms during closed-chest resuscitation. Chest 2005;127:1327-34.
4. Kolarova JD, Ayoub IM, Gazmuri RJ. Cariporide enables hemodynamically more effective chest compression by leftward shift of the flow-depth relationship. Am J Physiol Heart Circ Physiol 2005;288:H2904-11.
5. Ayoub IM, Kolarova J, Kantola RL, Sanders R, Gazmuri RJ. Cariporide minimizes adverse myocardial effects of epinephrine during resuscitation from ventricular fibrillation. Crit Care Med 2005 33:2599-605.

Book Chapters

1. Gazmuri RJ, Ayoub IM. Myocardial Effects of Sodium-Hydrogen Exchange Inhibition during Resuscitation from Ventricular Fibrillation. In: Dhalla NS, Takeda N, Singh M, and Lukas A (eds). Myocardial Ischemia and Preconditioning. Boston: Kluwer Academic Publishers, 2003, pp.375-388.
2. Gazmuri RJ, Ayoub IM. NHE-1 Inhibition: A Potential New Form of Treatment for Resuscitation from Cardiac Arrest. In: Karmazyn M, Avkiran M, Fliegel L (Ed). The Sodium-Hydrogen Exchanger. From Molecule to its Role in Disease. Kluwer Academic Publishers, 2003, pp.291-308.
3. Gazmuri RJ, Ayoub IM. Kolarova J. Inhibition of the Sodium-Hydrogen Exchanger: A Potential Treatment for Resuscitation from Cardiac Arrest. In: Vincent JL (ed). 2003 Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag, 2003, pp.461-471.
4. Gazmuri RJ, Gopalakrishnan P. Ventricular Arrhythmias. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.783-794.
5. Gazmuri RJ, Vidyarthi V. Cardioversion and Defibrillation. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.1807-1815.
6. Gazmuri RJ, Ayoub IM. Transvenous and Transcutaneous Pacing. In: Fink MP, Abraham E, Vincent JL, Kochanek P (eds). Textbook of Critical Care, 5th Edition. Philadelphia: Elsevier Inc., 2005, pp.1817-1824.
7. Gazmuri RJ, Weil MH, Kern K, Tang W, Ayoub IM, Kolarova JD, Radhakrishnan J. Prevention and Therapy of Postresuscitation Myocardial Dysfunction. In: Paradis N, Halperin H, Kern K, Wenzel V, Chamberlain D (eds). Cardiac Arrest - The Science and Practice of Resuscitation Medicine, 2nd Edition. Cambridge University Press (In Press)

Editorials and Commentaries

1. Gazmuri RJ, Kube E.  Capnography during cardiac resuscitation:  A clue on mechanisms and a guide to interventions.  Critical Care 2003;7:411-412.
2. Gazmuri RJ, Gopalakrishnan P.  Hypothermia:  Cooling down inflammation.  Crit Care Med 2003;31:2811-2812.
3. Gazmuri RJ.  Editorial:  Optimizando la calidad en medicina intensiva [Optimizing the quality of intensive care medicine].  Rev Chil Med Intensiva 2004;19:53-54.
4. Gazmuri RJ, Ayoub IM.  B-type natriuretic peptide for predicting outcomes after open heart surgery:  Superior than traditional scoring systems?  Crit Care Med 2005;33:459-460.
5. Gazmuri, RJ, Kolarova JD, Ayoub IM.  Inotropic options for post-resuscitation myocardial dysfunction.  Crit Care Med 2005;33:668-670.

Abstracts and Publications, and Recent Research of Frank Maldonado, MD. (2002-2006):

1. 2003  Ayoub IM, Kolarova J, Yi Z, Trivedi A, Deshmukh H, Lubell DL, Franz MR,     Maldonado FA, Gazmuri RJ.  Sodium-hydrogen exchange inhibition during ventricular fibrillation:  Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability.  Circulation 2003; 107:1804-9.

1. 2003-2005    Efficacy and Safety of Inhaled Human Insulin (Exubera®) Compared with Subcutaneous Human Insulin in the Therapy of Adult Subjects with Type 1 or Type 2 Diabetes Mellitus and Chronic Obstructive Pulmonary Disease:  A One-Year, Multicenter, Randomized, Outpatient, Open-Label, Parallel-Group Comparative Trial.  Protocol Number  A2171030

Sponsor:  Pfizer/Aventis

Role:  Co-Principal Investigator

2003-ongoing  Improving Antibiotic Use in Acute Care Treatment
The IMPAACT Project
Sponsor:  VA and AHRQ
Role:  Principal Investigator

Absracts and Publications of Dr. Ahmet Sinan Copur

1. HIV is a risk factor for venous thromboembolism under age 50.
   Copur AS, Smith PR, Victor Gomez, Michael Bergman
   Pulmonary Division of Long Island College Hospital/Brooklyn NY
   AIDS PATIENT CARE and STD 16:5:205-209, 2002
2. Resting Energy Expenditure in Patients with Pressure Sores:  
   Measured vs Estimated.
   Fulambarker A, Copur AS, Chandok S.
   North Chicago VA Medical Center Pulmonary Division.
   Am J Respir Crit Care, March 1998;157 (3):A838.
   (presented as a poster in “1998 International Conference of 
   American Thoracic Society in Chicago, IL)
3. Reference values for pulmonary function in Asian Indians living in
   the United States.
   Fulambarker A, Copur AS, Javeri A, Jere S, Cohen ME
   Pulmonary Division, Chicago Medical School/Rosalind Franklin
   University Chest. 2004 Oct;126(4):1225-33
4. US born Asian Indians have higher pulmonary volumes compared 
   to immigrant Asian Indians
   Copur AS, Fulambarker A, Cohen ME, Patel M, Sanjay Gill
   Chest. 128:392S, 2005
5. Investigation of Attitudes toward Asthma and Self Management 
   Strategies among Patients with Poor Income.
   McDermott M, Melman S, Rydman R, Copur AS.
   Cook County Hospital Emergency Department.
   Presented in SAEM meeting in 1998.
6. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S.   
   Independent Contributions of Chronic Obstructive Pulmonary
   Disease and Abdominal Aortic Aneurysm to Mortality Risk. 
   Chest. 128:265S, 2005

Abstract and Publications of Joseph Rosman, MD:

1. Comparison of Pulmonary Function in Immigrant versus U.S. Born Asian Indians. A Fulambarker, T Vinu, M Cohen, K Thottupuram, J Rosman, A Shenoy. Am J of Respir Crit Care Med. 2003. 167, A421.
   
2. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J. Maldonado, F. Chest. 128:392S, 2005
   
3. Cardiac Tamponade as a rare Primary presentation of Sarcoidosis Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Chest. 128: 464S, 2005

Abstracts and Publications and Current Research Projects of Sunita Kumar, MD.
           

1. Efficacy of empiric use of Auto-titrating CPAP in patients suspected of having obstructive sleep apnea (accepted as abstract for APSS 2006) Sunita Kumar, M.D.; Saroja Sripathi, M.D., Ashok Fulambarker, M.D. , Ahmad Rashid, M.D. North Chicago VA Medical Center, North Chicago, IL


2. Determining clinical markers to predict obstructive sleep apnea to improve access to polysomnography in a Veterans hospital.(Accepted as abstract for APSS
   2006)Authors: Saroja Sripathi M.D.; Sunita Kumar M.D.; Ashok Fulambarker M.D.
   North Chicago VA Medical Center and Rosalind Franklin University of Science and Medicine, North Chicago, IL


3.  The effect of treating obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) on low HDL (High density cholesterol) and the correlation with insulin resistance. Rami Arfoosh, M.D.; Sunita Kumar, M.D.; Ashok Fulambarker, M.D. North Chicago VA Medical Center and Rosalind Franklin University of Science and Medicine, North Chicago, IL


4. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005

Publications of Robert J. Bridges, PhD

1. Silvis, M.R., Picciano, J.A., Bertrand, C., Weixel, K., Bridges, R.J. and Bradbury, N.A.  (2003).  A mutation in the cystic fibrosis transmembrane conductance regulator generates a novel internalization sequence and enhances endocytic rates.  J. Biol. Chem. 278:11554-11560.


2. Bertrand, C.A., Laboisse, C., Hopfer, U., Danahay, H., Poll, C.T. and Bridges, R.J.  (2004).  Niflumic acid inhibits ATP-stimulated mucin exocytosis through a calcium dependent mechanism.  Am. J. Physiol. 286:C247-255.


3. Singh, A.K., Schultz, B.D., van Driessche, W., Bridges, R.J.  (2004).  Transepithelial fluctuation analysis of chloride secretion.  J. Cyst. Fibros. Suppl 2:127-132.


4. Kreindler, J.L., Jackson, A., Kemp, P., Bridges, R.J., and Danahay, H.  (2005). Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract.  Am. J. Physiol. Lung Cell Mol. Physiol.  288(5):L894-L902.


5. Adebamiro, A., Cheng, Y., Johnson, J.P., and Bridges, R.J.  (2005) Endogenous protease activation of ENaC: Effect of serine protease inhibition on ENaC single channel properties.  J. Gen. Physiol. 126(4):339-52.


6. Danahay, H., Atherton, H.C., Jackson, A.D., Kreindler, J.L., Poll, C.T. and Bridges, R.J.  (2006). Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium.  Am. J. Physiol. Lung Cell Mol. Physiol. 290:L588-L569.


7. Bertrand, C.A., Laboisse, C., Hopfer, U., Bridges, R.J. and Frizzell, R.A.  (2006). Methods for detecting internalized, FM 1-43 stained particles in epithelial cells reveal cell density-dependent membrane trafficking.  Biophysical Journal (in Press).

Publications of Mark Cohen, PhD

1. Stone, M. E., Cohen, M. E., Debban, B. A.  Mercury vapor levels in exhaust air from dental vacuum systems.  Dental Materials, in press.


2. Radel, R. T., Goodell, G.G., McClanahan, S. B., Cohen, M.E.  In Vitro radiographic Determination of distances from working length files to root ends comparing Kodak RVG 6000, Schick CDR and Kodak InSight Film. Journal of Endodontics, 2006, 32, 566-568.


3. Stone, M. E., Kuehne, J. C., Cohen, M. E., Talbott, J. L., Scott J. W.  Effect of iodine on mercury concentrations in dental unit wastewater.  Dental Materials, 2006, 22, 119-124.


4. Tiba, A., Charlton, D.G., Vandewalle, K.S., and Cohen, M. E.  Volumetric polymerization shrinkage under simulated intraoral temperature and humidity conditions.  Operative Dentistry, 2005, 30-6, 696-701.


5. Cohen M. E., Debban, B. A., Cohen, M. E. and Kuehne, J. C.  Hg levels in exhaust air from dental vacuum systems.  Journal of Dental Research 85, Special Issue A:  Abstract #0036, 2006.


6. Lvovsky D., Fulambarker, A., Cohen, M., Copur, A.S., and Kumar, S.  Independent contributions of chronic obstructive pulmonary disease and abdominal aortic aneurysm to mortality risk.  Chest, 128:265S, 2005.


7. Copur, A. S., Fulambarker, A. Cohen, M., Patel, M., Gill, S., George, C., Rosman, J., and Maldonado, F.  U.S. born Asian Indians have higher pulmonary function values compared to immigrant Asian Indians, Chest, 128:392S, 2005.


8. Stone, M. E., Cohen, M., and Kuehne, J. C.  Evaluation of low cost chairside filters as amalgam separators.  Journal of Dental Research 84, Special Issue A:  Abstract #2696, 2005.


9. Stone, M. E., Kuehne, J. C., and Cohen, M.  Mercuric iodide complexes in dental-unit wastewater.  Journal of Dental Research 84, Special Issue A:  Abstract #2697, 2005.

Past fellows publications (2004-2006)

1. Lvovsky, D. Fulambarker, A.  Cohen, M. Copur, AS. Kumar, S. Independent Contributions of Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm to Mortality Risk.  Chest. 128:265S, 2005


2. Lvovsky, D. Desuyo, E. Fulambarker, A. Rosman, J. Cardiac Tamponade as a rare Primary presentation of Sarcoidosis. Chest. 128: 464S, 2005


3. Copur, AS. Fulambarker, A.  Cohen, M. Patel, M. Gill, S. George, C. Rosman, J. Maldonado, F. U.S Born Asian Indians have higher Pulmonary Function values compared to Immigrant Asian Indians. Chest. 128:392S, 2005


4. Copur, AS. Javeri, Fulambarker, A. Jere, S.  Cohen M. Reference Values for Pulmonary Function in Asian Indians Living in the United States.  Chest. 126, 1225-1233, 2004.


5. Rashid, Ahmad M. Fulambarker, A. Cohen, M. Patel, B. Sood,V. Effects of Systemic Corticosteroids on Mechanically Ventilated Patients with Acute Exacerbation of COPD. Chest  126:805-806, 2004

Fellows’ Research Projects (2003-2006):
These projects are either completed with publications as above or still in progress. These projects will be completed and published. The cycling time from the inception of a research project and publication sometimes far exceeds the fellow’s two year training in the program.

1. Comparison of Pulmonary Function in Immigrant Versus U.S. Born Asian Indians. A Fulambarker, A. Copur, M Cohen. 2003-2006.
2. Role of Empiric Treatment with Auto-titrating CPAP in Patients with Suspected Sleep apnea. Sunita Kumar, A Fulambarker, Ahmad rashid 2005-2006
3. Determining Clinical Markers to Predict Obstructive sleep apnea to Improve Access Polysomnography in a Veterans Hospital. Sunita Kumar, A Fulambarker, S. Sripathi 2005-06
4. Efficacy of Inhaled Tobramycin in Moderate to Severe COPD patients colonized with Pseudomonas Aeruginosa. N Akkina, A Fulambarker 2006-07
5. Effect of YOGA on COPD Outcomes: A pilot Study. B. Farooki, A Fulambarker. 2006-07
6. Effect of Using Spirometry on Smoking Cessation Rate. Lavanya Srinivasan, Rami Arfoosh, A Fulambarker, M. Cohen. 2006-07
7. Effect of CPAP on High Density Lipoprotein Cholesterol in Obstructive Sleep Apnea. Rami Arfoosh, Sunita Kumar, A Fulambarker
8. Effect of Various Candidate Compounds on CFTR Mediated Ion Transport”. Swamy Nagubadi, MD, Robert Bridges, PhD

Current Fellows' Research Project:

1. Effect of Long Term Oxygen Therapy on Inflammation in COPD patients
Saroja Sripathi, Ahmet Copur, Ashok Fulambarker

2. Smoking Cessation and Spirometry
Lavanya Srinivasan, Rami Arfoosh, Ashok Fulambarker MD, Mark Cohen

3. Incidence of Sleep Disorders in Mild TBI
Srikanth Davuluri, Ashok Fulambarker

4. Effect of CPAP on Urinary Albumin Excretion
Mohamad Al-Massalkhi, Ahmet Copur, Ashok Fulambarker