Kuei Y. Tseng, M.D., Ph.D. Assistant Professor M.D., 1997, University of Buenos Aires, Argentina Ph.D., 2002 (Physiology and Neuroscience) University of Buenos Aires, Argentina Room: 2.172 Phone: 847-578-8655 Fax: 847-578-3268 E-mail: kuei.tseng@rosalindfranklin.edu
Biographical Sketch
Recent Publications
Research Interests 1
Tseng KY, Caballero A, Dec A, Cass DK, Simak N, Sunu E, Park MJ, Blume SR, Sammut S, Park DJ, West AR. Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism. PLoS One. 2011;6(11):e27187. Epub 2011 Nov 2.
McCutcheon JE, Loweth JA, Ford KA, Marinelli M, Wolf ME, Tseng KY. Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism. J Neurosci. 2011 Oct 12;31(41):14536-41.
West AR, Tseng KY. Nitric Oxide-Soluble Guanylyl Cyclase-Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease? Front Syst Neurosci. 2011;5:55. Epub 2011 Jun 30.
McCutcheon JE, Wang X, Tseng KY, Wolf ME, Marinelli M. Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci. 2011 Apr 13;31(15):5737-43.
Heng LJ, Markham JA, Hu XT, Tseng KY. Concurrent upregulation of postsynaptic L-type Ca(2+) channel function and protein kinase A signaling is required for the periadolescent facilitation of Ca(2+) plateau potentials and dopamine D1 receptor modulation in the prefrontal cortex. Neuropharmacology. 2011 May;60(6):953-62. Epub 2011 Feb 1.
Ferrario CR, Loweth JA, Milovanovic M, Ford KA, Galiñanes GL, Heng LJ, Tseng KY, Wolf ME. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca(2+)-permeable AMPA receptors during the incubation of cocaine craving. Neuropharmacology. 2011 Jan 27. [Epub ahead of print]
Heng L, Beverley JA, Steiner H, Tseng KY. Differential developmental trajectories for CB1 cannabinoid receptor expression in limbic/associative and sensorimotor cortical areas. Synapse. 2011 Apr;65(4):278-86. doi: 10.1002/syn.20844.
Steiner H, Tseng, KY (eds.) Handbook of Basal Ganglia Structure and Function. Elsevier 2010
Salgado H, Garcia-Oscos F, Patel A, Martinolich L, Nichols JA, Dinh L, Roychowdhury S, Tseng KY, Atzori M. Layer-Specific Noradrenergic Modulation of Inhibition in Cortical Layer II/III. Cereb Cortex. 2011 Jan;21(1):212-21. Epub 2010 May 13.
Feleder C, Tseng KY, Calhoon GG, O'Donnell P. Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats. Biol Psychiatry. 2010 Feb 15;67(4):386-92. Epub 2009 Nov 14.
Blume SR, Cass DK, Tseng KY. Stepping test in mice: a reliable approach in determining forelimb akinesia in MPTP-induced Parkinsonism. Exp Neurol. 2009 Sep;219(1):208-11. Epub 2009 May 19.
Tseng, KY (ed.) Cortico-Subcortical Dynamics in Parkinson’s Disease Cortico-Subcortical Dynamics in Parkinson’s Disease. Springer 2009
Tseng KY. Facing the lack of anti-phase oscillation in the parafascicular nucleus after dopamine depletion. Exp Neurol. 2009 Sep;219(1):62-5. Epub 2009 Jun 6.
Tseng KY, Chambers RA, Lipska BK. The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res. 2009 Dec 7;204(2):295-305. Epub 2008 Dec 3.
Tseng KY, Lewis BL, Hashimoto T, Sesack SR, Kloc M, Lewis DA, O'Donnell P. A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons. J Neurosci. 2008 Nov 26;28(48):12691-9.
Paz RD, Tardito S, Atzori M, Tseng KY. Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology. Eur Neuropsychopharmacol. 2008 Nov;18(11):773-86. Epub 2008 Jul 23.
Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M, Wolf ME. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving.Nature. 2008 Jul 3;454(7200):118-21. Epub 2008 May 25.
Snyder-Keller A, Tseng KY, Lyng GD, Graber DJ, O'Donnell P. Afferent influences on striatal development in organotypic cocultures. Synapse. 2008 Jul; 62(7):487-500. Epub 2008 Apr 24. Tseng KY, Atzori M. (eds.) Monoaminergic Modulation of Cortical Excitability. Springer 2007 Tseng KY, O'Donnell P. D(2) dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex. Synapse. 2007 Oct;61(10):843-50. Tseng KY, Lewis BL, Lipska BK, O'Donnell P. Post-Pubertal Disruption of Medial Prefrontal Cortical Dopamine-Glutamate Interactions in a Developmental Animal Model of Schizophrenia. Biol Psychiatry. 2007 Oct 1;62(7):730-8. Epub 2007 Jan 3. Tseng KY, O'Donnell P. Dopamine modulation of prefrontal cortical interneurons changes during adolescence. Cereb Cortex. 2007 May;17(5):1235-40. Epub 2006 Jul 3. Tseng KY, Snyder-Keller A, O'donnell P. Dopaminergic modulation of striatal plateau depolarizations in corticostriatal organotypic cocultures. Psychopharmacology (Berl). 2007 Apr;191(3):627-40. Epub 2006 Jun 7. Tseng KY, Amin F, Lewis BL, O'donnell P. Altered Prefrontal Cortical Metabolic Response to Mesocortical Activation in Adult Animals with a Neonatal Ventral Hippocampal Lesion. Biol Psychiatry 2006 Sep 15;60(6):585-90. Epub 2006 Jun 14. Tseng KY, Mallet N, Toreson KL, Le Moine C, Gonon F, O'Donnell P. Excitatory response of prefrontal cortical fast-spiking interneurons to ventral tegmental area stimulation in vivo. Synapse. 2006 Jun 1;59(7):412-7. Tseng KY, Kargieman L, Gacio S, Riquelme LA, Murer MG. Consequences of partial and severe dopaminergic lesion on basal ganglia oscillatory activity and akinesia. Eur J Neurosci. 2005 Nov;22(10):2579-86. Tseng KY, O'Donnell P. Post-pubertal emergence of prefrontal cortical up states induced by D1-NMDA co-activation. Cereb Cortex. 2005 Jan;15(1):49-57. Epub 2004 Jun 24. Tseng KY, O'Donnell P. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms. J Neurosci. 2004 Jun 2;24(22):5131-9. Tseng KY, Riquelme LA, Murer MG. Impact of D1-class dopamine receptor on striatal processing of cortical input in experimental parkinsonism in vivo. Neuroscience. 2004;123(2):293-8. Tseng KY, O'Donnell P. Dopamine-glutamate interactions in the control of cell excitability in medial prefrontal cortical pyramidal neurons from adult rats. Ann N Y Acad Sci. 2003 Nov;1003:476-8. Murer MG, Tseng KY, Kasanetz F, Belluscio M, Riquelme LA. Brain oscillations, medium spiny neurons, and dopamine. Cell Mol Neurobiol. 2002 Dec;22(5-6):611-32. Review. Erratum in: Cell Mol Neurobiol. 2003 Jun;23(3):449. Tseng KY, Kasanetz F, Kargieman L, Pazo JH, Murer MG, Riquelme LA. Subthalamic nucleus lesions reduce low frequency oscillatory firing of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease. Brain Res. 2001 Jun 15;904(1):93-103. Tseng KY, Kasanetz F, Kargieman L, Riquelme LA, Murer MG. Cortical slow oscillatory activity is reflected in the membrane potential and spike trains of striatal neurons in rats with chronic nigrostriatal lesions. J Neurosci. 2001 Aug 15;21(16):6430-9. Tseng KY, Roubert C, Do L, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Gershanik OS, Murer MG, Giros B, Raisman-Vozari R. Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice. Brain Res Mol Brain Res. 2000 Aug 14;80(1):1-6. Tseng KY, Riquelme LA, Belforte JE, Pazo JH, Murer MG. Substantia nigra pars reticulata units in 6-hydroxydopamine-lesioned rats: responses to striatal D2 dopamine receptor stimulation and subthalamic lesions. Eur J Neurosci. 2000 Jan;12(1):247-56.
Kuei Y. Tseng, M.D., Ph.D. Assistant Professor