Email: physiology@rosalindfranklin.edu Fax: 847.578.3265
Hawkins, Richard A Kim, Donghee
Najmabadi, Feridoon McCormack, Charles E. Peterson, Darryl R. Rasgado-Flores, Hèctor
Dr. Bridges' primary area of research is on epithelial ion transport with a special focus on epithelial ion channels. His lab uses a wide range of electrophysiological methods and video imaging to study the regulation, pharmacology and biophysics of ion channels including CFTR, ENaC and various potassium channels. He collaborates with several pharmaceutical companies working toward the development of drugs for the treatment of Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Recent Publications
Devor, D. C., Singh, A.K., Lambert, L.C., DeLuca, A., Frizzell, R.A., and Bridges, R.J. (1999). Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J. Gen Physiol. 113:743-760.
Devor, D.C., Bridges, R.J., and Pilewski, J.M. (2000). Pharmacological modulation of ion transport across wild-type and ?F508 CFTR-expressing human bronchial epithelia. Am. J. Physiol. 279:C461-C479.
Bridges, R.J., Newton, B.B., Pilewski, J.M., Devor, D.C., Poll, C.T., and Hall, R.L. (2001). Na transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437. Am. J. Physiol. 281:L16-L23.
Singh, A.K., Schultz, B.D., van Driessche, W., Bridges, R.J. (2004). Transepithelial fluctuation analysis of chloride secretion. J. Cyst Fibros. Suppl 2:127-132.
Kreindler, J.L., Jackson, A., Kemp, P., Bridges, R.J., Danahay, H. (2004). Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract. Am. J. Physiol. Lung Cell Mol. Physiol. Epub.
Schultz, B.D., Singh, A.K., Devor, D.C. and Bridges, R.J. (1999). Pharmacology of CFTR chloride channel activity. Physiological Reviews 79:S109-S144.