Email: physiology@rosalindfranklin.edu Fax: 847.578.3265
Hawkins, Richard A Kim, Donghee
Najmabadi, Feridoon McCormack, Charles E. Peterson, Darryl R. Rasgado-Flores, Hèctor
Our research focuses on the activity of ion channel proteins in biological membranes and on chloride channels in particular. These channels are involved in a variety of aspects of cellular maintenance such as in cell volume regulation, mechano-sensitivity and fluid secretion in addition to regulation of pathological conditions such as cystic fibrosis, myotonia, edema, stroke and polydipsia (water intoxication). We use a combined approach including electrophysiological, molecular, biochemical and imaging techniques to unravel the mechanisms regulating chloride channel activity by neurotransmitters and intracellular anions such as aspartate and glutamate and cytosolic structures such as the cytoskeleton.
Recent Publications
Levitan, I., C. Almonte, P. Mollard and S.S. Garber. (1995). Modulation of a Volume-Regulated Cl- Current by F-actin. J. Membr. Biol. 147:283-294 Levitan, I., and S.S. Garber. (1995) Voltage-dependent inactivation of volume regulated Cl- current in T84 and Myeloma cells. Pflgers Arch. 431:297-299 Garber, S.S., M. White and M. Chanson. (1996) cAMP Promotes Gap Junctional Coupling in T84 cells. Am. J. Physiol. 271:C533-C539 Verghese, C. I. Levitan, S.S. Garber, C. Nair, G. Abraham and R.C. Josiassen. (1997) Impaired lymphocyte volume regulation in schizophrenic patients with polydipsia-hyponatremia. Biological Psychiatry 42:733-736 Levitan, I. and Garber, S.S. (1998) Anion competition for a volume regulated current. Biophysical Journal 75:226-235