Selected Publications

"The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity." Aluvila S., Kotaria R., Sun J., Mayor J.A., Walters D.E., Harrison D.H., Kaplan R.S. J. Biol. Chem. 285 27314-27326 (2010) medline.

"Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor." Aluvila S., Sun J., Harrison D.H., Walters D.E., Kaplan R.S. Mol. Pharmacol. 77 26-34 (2010) medline.

"The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate." Remani S,. Sun J., Kotaria R., Mayor J.A., Brownlee J.M., Harrison D.H., Walters D.E., Kaplan R.S. J. Bioenerg. Biomembr. 40 577-585 (2008) medline.

"Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate."Brownlee J., He P., Moran G.R., Harrison D.H. Biochemistry 47 2002-2013 (2008) medline.

"Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes." Brownlee J.M., Carlson E., Milne A.C., Pape E., Harrison D.H. Bioorg. Chem. 34 424-444 (2006) medline.

"The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism." Bohren K.M., Brownlee J.M., Milne A.C., Gabbay K.H., Harrison D.H. Biochim Biophys Acta 1748 201-212 (2005) medline.

"The F1-ATPase beta-subunit is the putative enterostatin receptor", Park M, Lin L, Thomas S, Braymer HD, Smith PM, Harrison DH, York DA. Peptides 25: 2127-33 (2004). medline.

"3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time".", Theisen M.J., Misra I., Saadat D., Campobasso N., Miziorko H.M., Harrison D.H. PNAS 101 16442-16447 (2004) medline.

"Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC." Brownlee J.M., Johnson-Winters K., Harrison D.H., Moran G.R. Biochemistry 43 6370-6377 (2004) medline.

"Mutagenic studies on histidine 98 of methylglyoxal synthase: effects on mechanism and conformational change."Marks G.T., Susler M., Harrison D.H. Biochemistry 43 3802-3813 (2004) medline.

"Functional specificities of methylglyoxal synthase and triosephosphate isomerase: a combined QM/MM analysis", Zhang X, Harrison DH, Cui Q. J Am Chem Soc.124: 14871-8 (2002) medline.

"Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy", Marks GT, Harris TK, Massiah MA, Mildvan AS, Harrison DH. Biochemistry 40 :6805-18 (2001) medline.

"Mirroring perfection: the structure of methylglyoxal synthase complexed with the competitive inhibitor 2-phosphoglycolate", Saadat D, Harrison DH. Biochemistry 39: 2950-60 (2000) medline.

"Identification of the allosteric regulatory site in bacterial phosphoribulokinase", Kung G, Runquist JA, Miziorko HM, Harrison DH. Biochemistry 38: 15157-65 (1999) medline.

"Rhodobacter sphaeroides phosphoribulokinase: identification of lysine-165 as a catalytic residue and evaluation of the contributions of invariant basic amino acids to ribulose 5-phosphate binding", Runquist JA, Harrison DH, Miziorko HM. Biochemistry 38:13999-4005 (1999) medline.

"The Crystal Structure of Methylglyoxal Synthase from Escherichia coli." Sadaat, D. and Harrison D. H. T. Structure 7:309-317 (1999) medline.

"Identification of Catalytic Bases in the Active Site of Escherichia coli Methylglyoxal Synthase: Cloning, Expression, and Functional Characterization of Conserved Aspartic Acid Residues" Saadat, D., Harrison, D. H. T. Biochemistry 37:10074-10086 (1998) medline.

"The crystal structure of phosphoribulokinase from Rhodobacter sphaeroides reveals a fold similar to that of adenylate kinase", Harrison DH, Runquist JA, Holub A, Miziorko HM. Biochemistry 37: 5074-85 (1998) medline.

"Functional evaluation of invariant arginines situated in the mobile lid domain of phosphoribulokinase", Runquist JA, Harrison DH, Miziorko HM. Biochemistry 37: 1221-6 (1998) medline.

"The Crystal Structure of Phosphoribulokinase from Rhodobacter sphaeroides Reveals a Fold Similar to Adenylate Kinase." Harrison, D. H. T., Runquist, J. A., Holub, A., Miziorko, H. M. Biochemistry 37:5074-5085 (1998) medline.

"The Alrestatin Double-Decker: Binding of Two Inhibitor Molecules to Human Aldose Reductase Reveals a New Specificity Determinant", D.H. Harrison, K.M. Bohren, G.A. Petsko, D. Ringe and K.H. Gabbay. Biochemistry, 36: 16134-16140 (1997) medline.

"Structure of the regulatory domain of scallop myosin at 2.8 A resolution", Xie X, Harrison DH, Schlichting I, Sweet RM, Kalabokis VN, Szent-Györgyi AG, Cohen C. Nature 368: 306-12 (1994) medline.

"An Anion Binding Site in Human Aldose Reductase: Mechanistic Implications for the Binding of Citrate, Cacodylate and Glucose-6-Phosphate", D.H. Harrison, K.M. Bohren, D. Ringe, G.A. Petsko and K.H. Gabbay. Biochemistry, 33: 2011 (1994) medline.

"Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme." Biochemistry 33:2021-32 (1994) medline.

"Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase", Bohren KM, Wermuth B, Harrison D, Ringe D, Petsko GA, Gabbay KH. J Mol Biol. 244: 659-64 (1994) medline.

"Structure of the human ADP-ribosylation factor 1 complexed with GDP", Amor JC, Harrison DH, Kahn RA, Ringe D. Nature 372: 704-8 (1994) medline.

"Determination of the relative percentage deuteration of the ribosomal protein S4 by electrospray ionization mass spectrometry", Gulcicek EE, Harrison DH, Shen S. Arch Biochem Biophys. 308: 24-30 (1994) medline.

"Insights into interfacial activation from an open structure of Candida rugosa lipase", Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M. J Biol Chem. 268: 12843-7 (1993) medline.

"Determination of the Radius of Gyration of S4 and Other Ribosomal Components by the Triple Isotopic Method", Harrison DH, May RP, Moore PB. J. Appl. Cryst. 26:198-206 (1993).

"Crystal structure and anti herpes simplex virus activity of 2,2'-anhydro-1-beta-D-arabinofuranosylthymine", Harrison DH, Schinazi RF, Rubin BH. J Med Chem. 25:1507-10 (1982) medline.

Invited Publications

Runquist, J. A., Koteiche, H. A., Harrison, D. H. T., Miziorko, H. M. (1999) "Phosphoribulokinase: Mutagenesis of the Mobile Lid and 'P-loop"' in the Xlth International Photosynthesis Congress. Budapest, Hungary (August 17-22, 1998) Kluwer Academic Publishers

Miziorko, H. M., Runquist, J. A., Harrison, D. H. T. (1999) "Phosphoribulokinase: 3-dimensional structure and catalytic mechanism" in Xlth International Photosynthesis Congress. Budapest, Hungary (August 17-22, 1998) Kluwer Academic Publishers

Harrison, D. H. T., Bohren, K.M., Gabbay, K. H. (1996) "In reply - Some are not in the family" News and Views, Nature Structural Biology, 3:660-661

Harrison, D. H. T. (News and Views) (1995) "All in the Family" Nature Structural Biology 2:719-720 medline.