Sun, J., Aluvila, S., Kotaria, R., Mayor, J.A., Walters, D.E., and Kaplan, R.S., Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol. Cell. Pharmacol. 2: 101-110 (2010). [pubmed] Aluvila, S., Sun, J., Mayor, J.A., Kotaria, R., Walters, D.E., Harrison, D.H.T., and Kaplan, R.S., The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity. J. Biol. Chem. 285: 27314-27326 (2010). [pubmed] Mayor JA, Sun J, Kotaria R, Walters DE, Oh KJ, Kaplan R.S., Probing the effect of transport inhibitors on the conformation of the mitochondrial citrate transport protein via a site-directed spin labeling approach. J Bioenerg Biomembr. 42: 99-109 (2010). [pubmed] Aluvila S, Sun J, Harrison DH, Walters DE, Kaplan R.S., Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor. Mol Pharmacol. 77: 26-34 (2010). [pubmed] Remani, S., Sun, J., Kotaria, R., Mayor, J.A., Brownlee, J.M., Harrison, D.H.T., Walters, D.E., and Kaplan, R.S., The Yeast Mitochondrial Citrate Transport Protein: Identification of the Lysine Residues Responsible for Inhibition Mediated by Pryidoxal 5’-phosphate. J. Bioenerg. Biomembr. 40: 577-585 (2008). [pubmed] Kaplan, R.S. and June A. Mayor, Molecular Structure of the Mitochondrial Citrate Transport Protein, In: Advances in Biochemistry in Health and Disease: Mitochondria – The Dynamic Organelle, (Schafer, S.W., and Suleiman, M.-S. Eds.), Springer, New York, pp. 97 - 116 (2007). Ma, C., Remani, S., Sun, J., Kotaria, R., Mayor, J.A., Walters, D.E., and Kaplan, R.S., Identification of the Substrate Binding Sites within the Yeast Mitochondrial Citrate Transport Protein. J. Biol. Chem. 282: 17210-17220 (2007). [pubmed] Ma, C., Remani, S., Kotaria, R., Mayor, J.A., Walters, D.E., and Kaplan, R.S., The Mitochondrial Citrate Transport Protein: Evidence for a Steric Interaction Between Glutamine 182 and Leucine 120 and its Relationship to the Substrate Translocation Pathway and Identification of Other Mechanistically Essential Residues. Biochim. Biophys. Acta 1757: 1271-1276 (2006). [pubmed] Ma, C., Kotaria, R., Mayor, J.A., Remani, S., Walters, D.E., and Kaplan, R.S., The Yeast Mitochondrial Citrate Transport Protein: Characterization of Transmembrane Domain III Residue Involvement in Substrate Translocation. J. Biol. Chem 280: 2331-2340 (2005). [pubmed] Cascio, M., Mayor, J.A., and Kaplan, R.S., Analysis of the Secondary Structure of the Cys-less Yeast Mitochondrial Citrate Transport Protein and Four Single-Cys Variants by Circular Dichroism. J. Bionerg. and Biomembr. 36: 429-438 (2004). [pubmed] Walters, D.E. and Kaplan, R.S., Homology Modeled Structure of the Yeast Mitochondrial Citrate Transport Protein. Biophys. J. 87: 907-911 (2004). [pubmed] Ma, C. Kotaria, R., Mayor, J.A., Eriks, L.R., Dean, A.M., Walters, D.E., and Kaplan, R.S., The Mitochondrial Citrate Transport Protein: Probing the Secondary Structure of Transmembrane Domain III, Identification of Residues that Likely Comprise a Portion of the Citrate Transport Pathway, and Development of a Model for the Putative TMDIII-TMDIII' Interface. J. Biol. Chem. 279: 1533-1540 (2004). [pubmed] Eriks, L.R., Mayor, J.A., and Kaplan, R.S., A Strategy for Identification and Quantification of Detergents Frequently Used in the Purification of Membrane Proteins. Anal. Biochem. 323: 234-241 (2003). [pubmed] R.S. Kaplan, Methanethiosulfonate Reagent Accessibility Studies, Cysteine-scanning Mutagenesis, Protein Overexpression, and Functional Reconstitution: A Strategy for Studying the Structure/Function Relationships within the Mitochondrial Citrate Transport Protein. In: Transmembrane Transporters, Quick, M.W., Ed., Wiley-Liss, New Jersey, pp. 143-159 (2002). R.S. Kaplan, Structure and Function of Mitochondrial Anion Transport Proteins. J. Membrane Biol. 179: 165-183 (2001). [pubmed] D.E. Walters and R.S. Kaplan. Models of the Transmembrane Domains of the Yeast Mitochondrial Citrate Transport Protein. J. Molecular Modeling 6: 587-594 (2000). R.S. Kaplan, J.A. Mayor, R. Kotaria, D.E. Walters, and H.S. Mchaourab. The Yeast Mitochondrial Citrate Transport Protein: Determination of Secondary Structure and Solvent Accessibility of Transmembrane Domain IV Using Site-directed Spin Labeling. Biochemistry 39: 9157-9163 (2000). [pubmed] R.S. Kaplan, J.A. Mayor, D. Brauer, R. Kotaria, D.E. Walters, and A.M. Dean. The Yeast Mitochondrial Citrate Transport Protein: Probing the Secondary Structure of Transmembrane Domain IV and Identification of Residues that Likely Comprise a Portion of the Citrate Translocation Pathway. J. Biol. Chem. 275: 12009-12016 (2000). [pubmed] Y. Xu, D.A. Kakhniashvili, D.A. Gremse, D.O. Wood, J.A. Mayor, D.E. Walters, and Kaplan, R.S.. The Yeast Mitochondrial Citrate Transport Protein: Probing the Roles of Cysteines, Arg181, and Arg189 in Transporter Function. J. Biol. Chem. 275: 7117-1724 (2000). [pubmed] R. Kotaria, J.A. Mayor, D.E. Walters, and R.S. Kaplan, Oligomeric State of Wild-Type and Cysteine-Less Yeast Mitochondrial Citrate Transport Proteins. J. Bioenerg. Biomembr. 31: 543-549 (1999). [pubmed] Kaplan, R.S. and Pedersen, P.L., Sensitive Protein Assay in Presence of High Levels of Lipid. In: Biomembranes: Selected Methods in Enzymology, (Packer, L. and Fleischer, S.), Academic Press, New York, pp. 397-403 (1997). Kakhniashvili, D., Mayor, J.A., Gremse, D.A., Xu, Y., and Kaplan, R.S., Identification of a Novel Gene Encoding the Yeast Mitochondrial Dicarboxylate Transport Protein via Overexpression, Purification and Characterization of its Protein Product, J. Biol. Chem. 272: 4516-4521 (1997). [pubmed] Mayor, J.A., Kakhniashvili, D., Gremse, D.A., Campbell, C., Krämer, R., Schroers, A., Kaplan, R.S., Bacterial overexpression of putative yeast mitochondrial transport proteins, J. Bioenerg. Biomembr. 29: 541-547 (1997). [pubmed] Kaplan, R.S., Mayor, J.A., Kakhniashvili, D., and Nelson, D., Deletion of the Nuclear Gene Encoding the Mitochondrial Citrate Transport Protein From Saccharomyces cerevisiae, Biochem. Biophys. Res. Commun. 226: 657-662 (1996). [pubmed] Kaplan, R.S., Mitochondrial Transport Processes. In: Molecular Biology of Membrane Transport Disorders, (Schultz, S.G., Andreoli, T., Brown, A., Fambrough, D., Hoffman, J. and Welsh, J. eds.), Plenum, New York, pp. 277-302, (1996). Kaplan, R.S., High-level bacterial expression of mitochondrial transport proteins, J. Bioenerg. Biomembr. 28: 41-47 (1996). [pubmed] Kaplan, R.S., Mayor, J.A., Gremse, D.A., and Wood, D.O., High-Level Expression and Characterization of the Mitochondrial Citrate Transport Protein From the Yeast Saccharomyces cerevisiae. J. Biol. Chem. 270: 4108-4114 (1995). [pubmed] Xu Y., Mayor J.A., Gremse D., Wood D.O., Kaplan R.S., High-yield bacterial expression, purification, and functional reconstitution of the tricarboxylate transport protein from rat liver mitochondria, Biochem. Biophys. Res. Commun. 207: 783-789 (1995) [pubmed] Gremse D.A., Dean B., Kaplan R.S., Effect of pyridoxal 5'-phosphate on the function of the purified mitochondrial tricarboxylate transport protein, Arch. Biochem. Biophys. 316: 215-219 (1995) [pubmed] Kaplan, R.S., Mayor, J.A. and Wood, D.O., The Mitochondrial Tricarboxylate Transport Protein: cDNA Cloning, Primary Structure, and Comparison With Other Mitochondrial Transport Proteins, J. Biol. Chem. 268: 13682-13690 (1993). [pubmed] Kaplan R.S., Mayor J.A., Blackwell R., Wilson G.L., Schaffer S.W., Functional levels of mitochondrial anion transport proteins in non-insulin-dependent diabetes mellitus, Mol. Cell Biochem. 107: 79-86 (1991) [pubmed] Kaplan R.S., Mayor J.A., Blackwell R., Maughon R.H., Wilson G.L., The effect of insulin supplementation on diabetes-induced alterations in the extractable levels of functional mitochondrial anion transport proteins, Arch. Biochem. Biophys. 287: 305-311 (1991) [pubmed] Kaplan, R.S., Mayor, J.A., Johnston, N. and Oliveira, D.L., Purification and Characterization of the Reconstitutively Active Tricarboxylate Transporter From Rat Liver Mitochondria. J. Biol. Chem. 265: 13379-13385 (1990). [pubmed] Kaplan, R.S., Oliveira, D.L. and Wilson, G.L., Streptozotocin-Induced Alterations In The levels of Functional Mitochondrial Anion Transport Proteins, Arch. Biochem. Biophys. 280: 181-191 (1990). [pubmed]
Last updated by Correll November 2, 2010