Kenneth D. Beaman, Ph.D.

Professor and Director,
Clinical Immunology Lab
Room 2.238
Building: BS
Phone: (847) 578-3449
E-mail: kenneth.beaman@rosalindfranklin.edu

Biography

Dr. Kenneth Beaman received his Bachelors Degree in 1975 from Colorado State University. He was a fellow in the Clinical Microbiology Lab at the Cleveland Clinic Foundation from 1975 to 1978. He received his Ph.D. from the Ohio State University in Microbiology and Immunology in 1982. He was a postdoctoral fellow in the Department of Pathology at Yale from 1982 to 1985. During his fellowship at Yale University he was a member of the transplantation laboratory. His research interests are in clinical immunology and in immune suppression, particularly during pregnancy. In 1985, he joined the Department of Microbiology and Immunology at the Chicago Medical School. He founded the Clinical Immunology Laboratory at the Chicago Medical School in 1987. The Clinical Immunology Laboratory supports a variety of autoimmune/rheumatology testing but primarily is interested in diagnostic tests pertaining to the immunology of pregnancy. Dr. Beaman is a fellow of the American Association of Medical Laboratory Immunologists and a Diplomat of the American Board of Medical Laboratory Immunology. The Clinical Immunology Laboratory is one of three laboratories in the United States certified by the Committee on Postdoctoral Educational Program (CPEP) approved postdoctoral training in Clinical Immunology that is accredited by the American Society of Microbiology. He is on the council of several national and international societies of both Reproductive and Clinical Immunology.

Director, Clinical Immunology Laboratory

The Clinical Immunology Laboratory performs over 1.3 million diagnostic tests for national and international clinics and physicians per year. 

The Clinical Immunology Laboratory at Rosalind Franklin University was established in 1988 as a pioneering laboratory specializing in cutting-edge immunological tests. It was one of the first to provide immunological testing for the diagnosis of recurrent pregnancy losses and unexplained infertility. The laboratory offers innovative immune assays, using both immunological and molecular biology methodology and state-of-the-art instruments. It provides services to physicians and patients nationally and internationally.

The laboratory, being part of Rosalind Franklin University of Medicine and Science, has performed scientific research in the field of human reproduction for over two decades and has been established as a leading center in the area of reproductive immunology. The laboratory serves local and national and international physicians and patients with the implementation of new diagnostic assays. In 1997, the Clinical Immunology Laboratory at Rosalind Franklin University established one of 3 Programs in the United States that is certified by the American Academy of Microbiology to educate postdoctoral students that are eligible for the American Board of Medical Laboratory Immunology. American Board of Medical Laboratory Immunology certifies the expertise of doctoral-level immunologists seeking to direct laboratories engaged in the practice of medical laboratory immunology. ABMLI certification is recognized by federal and state governmental agencies as a significant component toward meeting licensure requirements to direct laboratories engaged in the microbiological diagnosis of human disease. It is recognized under the Clinical Laboratory Improvement Amendments of 1988 final rule. There are 13 fellows educated through the program and are directors of Clinical laboratories throughout the US and Canada several others have come to the program as part of Sabbatical leaves to study at the Laboratory. These students are on faculty of many International Universities and are listed in students section above. The Clinical Laboratory provided services in flow cytometry for the Departments of Microbiology and Immunology, Pathology, Podiatry and Medicine.

Research Interests

The immune response to tumors and pregnancy is unique. In both cases the initial immune response is absent as measured by standard techniques such as the mixed lymphocyte reaction. This is thought to be due to the absence of HLA antigen on trophoblasts or tumors during a portion of their growth cycle. However, when other parameters are measured, unique immunological mechanisms can be seen, such as unique populations of mononuclear cells as well as a unique cytokine milieu associated with the tissue. 

General hypothesis: under certain stressful developmental conditions such as low pH and tumor growth, the first initiation of the immune response may be cytokine production and not antigen recognition. This cytokine production can precede antigen recognition by either the innate or adaptive immune response. This production of cytokines regulates the immune response both independent of and prior to antigen recognition by creating a unique environment for later antigen driven development.

Selected Publications

Varkha Agrawal, Mukesh Kumar Jaiswal, Vladimir Ilievski, Kenneth D. Beaman, Tamas Jilling, and Emmet Hirsch. Platelet Activating Factor: a Role in Preterm Delivery and an Essential Interaction with Toll-Like Receptor Signaling in Mice. Biology of Reproduction. 2014  91(5):0, 1–11 September 2014. DOI 10.1095/biolreprod.113.116012

Jaiswal M.K., Katara G.K., Mallers T.M., Chaouat G., Gilman-Sachs A., Beaman K.D. (2014). Vacuolar-ATPase isoform a2 regulates macrophages and cytokine profile necessary for normal spermatogenesis in testis. Journal of Leukocyte Biology. 2014 Aug;96(2):337-47.

Ota K, Yamagishi SI, Kim M, Dambaeva S, Gilman-Sachs A, Beaman K, Kwak-Kim J. Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in recurrent pregnancy losses (RPL): possible participation of RAGE in RPL. Fertil Steril. 2014 Jul 17. pii: S0015-0282(14)00543-3.

Beaman KD, Jaiswal MK, Dambaeva S, Gilman-Sachs A. Future directions of clinical laboratory evaluation of pregnancy.  Cell Mol Immunol. 2014 Jul 21. doi: 10.1038/cmi.2014.62.

Chueh FY, Cronk RJ, Alsuwaidan AN, Mallers TM, Jaiswal MK, Beaman KD, Yu CL., Mouse LSTRA leukemia as a model of human natural killer T cell and highly aggressive lymphoid malignancies. Leuk Lymphoma. 2014 Mar;55(3):706-8.

Kwak-Kim J, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, Beaman K, Kim JW, Gilman-Sachs A., Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. Am J Reprod Immunol. 2013 Jun;69(6):596-607.

Katara GK, Jaiswal MK, Kulshrestha A, Kolli B, Gilman-Sachs A, Beaman KD, Tumor-associated vacuolar ATPase subunit promotes tumorigenic characteristics in macrophages. Oncogene. 2013 Dec 23.

Jaiswal MK, Agrawal V, Mallers T, Gilman-Sachs A, Hirsch E, Beaman KD., Regulation of apoptosis and innate immune stimuli in inflammation-induced preterm labor. J Immunol. 2013 Dec 1;191(11):5702-13.

Kuniaki Ota, Svetlana Dambaeva,  Kenneth D. Beaman, Alice Gilman-Sachs, Joanne Kwak-Kim. Persistent high levels of IgM antiphospholipid antibodies in a paient with recurrent pregnancy losses and rheumatoid arthritis. 2013 Am J Reprod Immunol

Kuniaki Ota, Svetlana Dambaeva,  Kenneth D. Beaman, Alice Gilman-Sachs, Joanne Kwak-Kim. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Human Reprod. 2013 Nov 24

Kuniaki Ota, Mukesh Kumar Jaiswal, Sivakumar Ramu, Rajasinjham Jeyendran, Joanne Kwak-Kim, Alice Gilman-Sachs, Kenneth D. Beaman Expression of a2 Vacuolar ATPase in Spermatozoa is Associated with Semen Quality and Chemokine-Cytokine Profiles in Infertile Men  Research Article PLOS ONE 2013 Jul 30;8(7)

Kwong C, Gilman-Sachs A, Beaman K. An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase. OncoImmunology 2013 2:1 e22978-1 - e22978-10

Han AR, Ahn H, Vu P, Park JC, Gilman-Sachs A, Beaman K, Kwak-Kim J., Obstetrical Outcome of Anti-Inflammatory and Anticoagulation Therapy in Women with Recurrent Pregnancy Loss or Unexplained Infertility. Am J Reprod Immunol 2012 Jul 27.

Jaiswal MK, Mallers TM, Larsen B, Kwak-Kim J, Chaouat G, Gilman-Sachs A, Beaman KD., V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012 May;143(5):713-25.

Beaman KD, Ntrivalas E, Mallers TM, Jaiswal MK, Kwak-Kim J, Gilman-Sachs A,  Immune etiology of recurrent pregnancy loss and its diagnosis. Am J Reprod Immunol. 2012 Apr;67(4):319-25.

Jaiswal MK, Mallers TM, Kwong C, Chaouat G, Gilman-Sachs A, Beaman KD. Abortion-Prone Mating Influences Alteration of Systemic a2 Vacuolar ATPase Expression in Spleen and Blood Immune Cells. Am J Reprod Immunol. 2012 Jan 6. 67(5) 421-33.

Kim DJ, Linnstaedt S, Palma J, Park JC, Ntrivalas E, Kwak-Kim JY, Gilman-Sachs A, Beaman K, Hastings ML, Martin JN, Duelli DM. Plasma components affect accuracy of circulating cancer-related microRNA quantitation. J Mol Diagn. 2012 Jan;14(1):71-80.

Kwong C, Gilman-Sachs A, Beaman K. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011 Feb 1;186(3):1781-9.

Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD. Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice. Biol Reprod. 2011 Sep;85(3):626-34.

Kim NY, Cho HJ, Kim HY, Yang KM, Ahn HK, Thornton S, Park JC, Beaman K, Gilman-Sachs A, Kwak-Kim J. Thyroid Autoimmunity and its Association with Cellular and Humoral Immunity in Women with Reproductive Failures. Am J Reprod Immunol. 2011 July; 65 (1) :78-87

Ntrivalas E, Levine R, Kwong C, Gilman-Sachs A, Beaman K. J The a2 isoform of vacuolar ATPase is a modulator of implantation and feto-maternal immune tolerance in early pregnancy. Reprod Immunol. 2010 May;85(1):106-11.

Yang KM, Ntrivalas E, Cho HJ, Kim NY, Beaman K, Gilman-Sachs A, Kwak-Kim J. Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation. Am J Reprod Immunol. 2010 May;63:370-8.

Wang JH, Zheng X, Ke X, Dorak MT, Shen Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection. J Virology Journal 2009 6:46

Fukui A, Ntrivalas E, Fukuhara R, Fujii S, Mizunuma H, Gilman-Sachs A, Beaman K, Kwak-Kim J. Correlation between natural cytotoxicity receptors and intracellular cytokine expression of peripheral blood NK cells in women with recurrent pregnancy losses and implantation failures. Am J Reprod Immunol. 2009 Dec;62(6):371-80.

Wang, Xin Zheng, Xiaogang Ke, M. Tevfik Dorak, Jingjing Shen, Basmattee Boodram, Maurice O’Gorman, Ronald Hershow, Kenneth Beaman, Scott J. Cotler. Ethnic and geographical differences in HLA-gene controlled associations affect the outcome of hepatitis C virus infection. Virol J 2009. May 1;6:46.

E. Odessey,  A. Cohn, K. Beaman, L. Schechter, Invasive mucormycosis of the maxillary sinus: extensive destruction with an indolent presentation. Surg Infect (Larchmt). 2008 Feb;9(1):91-8. Review.

A. Fukui, J. Kwak-Kim, E. Ntrivalas, A. Gilman-Sachs, S.-K. Lee and K. Beaman, Intracellular cytokine expression of peripheral blood natural killer cell subsets in women with recurrent spontaneous abortion and implantation failures, Fertil Steril, 2007; Jan;89(1):157-65

E. Ntrivalas, R. Derks, A. Gilman-Sachs, J. Kwak-Kim and K. Beaman, Novel role for N-terminus domain of A2 isoform of Vacuolar ATPase IL-1 Production, Human Immunolog 2007;68:469-477

E. Ntrivalas, Gilman-Sachs A, Kwak-Kim and Beaman K., The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate IL-1  production from monocnuclear cells in co-culture with choriocarcinoma cells, Am J Reprod Immunol 2007;57(3):201-209

Fukui A, Ntrivalas E, Gilman-Sachs A, Kwak-Kim J, Lee SK, Levine R, Beaman K. Expression of Natural Cytotoxicity Receptors and a2V-ATPase on Peripheral Blood NK Cell Subsets in Women with Recurrent Spontaneous Abortions and Implantation Failures. Am J Reprod Immunol. 2006 Nov;56(5-6):312-20.

Roth P, Aulwurm S, Gekel I, Beier D, Sperry RG, Mittelbronn M, Meyermann R, Beaman KD, Weller M, Wischhusen J. Regeneration and tolerance factor: a novel mediator of glioblastoma-associated immunosuppression. Cancer Res. 2006 Apr 1;66(7):3852-8.

E. Ntrivalas, J. Kwak-Kim. K. Beaman, H. Mantouvalos and A. Gilman-Sachs: An in vitro model to study cytokine profiles of natural killer cells during maternal immune cell-trophoblast interactions, 2006 J.  Society for Gynecologic Invest., 2006;Apr;13(3):196-202.

Levine RF, Derks R, Beaman KD Regeneration and tolerance factor. A vacuolar ATPase with consequences. Chem Immunol Allergy. 2005;89:126-34.

Ntrivalas EI, Bowser CR, Kwak-Kim J, Beaman KD, Gilman-Sachs A: Expression of killer immunoglobulin-like receptors (KIRs) on peripheral blood NK cells subsets of women with recurrent spontaneous abortions or implantation failures. 2005 Am J Reprod Immunol. 53:215-221.

Updated: 11.26.2014

 

Life in Discovery
Important Links
3333 Green Bay Road, North Chicago, Il 60064-3095 • 847-578-3000