Home
Publications
Recent Papers: 59. Haghighat, N. and McCandless, D.W. (1997). Effect of 6-Aminonicotinamide on Metabolism of Astrocytes and C6-Glioma Cells. (Metabolic Brain Disease, 12 (1): 29-45.
60. Scott, W.J., Schreiner, C.M., Nau, H., Vorhees, C.V., Beliles, R.P., Colvin, J., and McCandless, D.W. (1997) Valproate-induced limb malformations in mice associated with reduction of intracellular pH. Reprod. Toxicol. 11: 483-493.
61. McCandless, D.W., and Haghighat, N. (1997) Effect of Amonium Chloride on Metabolism of Astrocytes and C6-Glioma Cells. Metabolic Brain Disease. 12 (4) 1997.
62. Scott, W.J., Schreiner, C., Beliles, R., and McCandless, D.W. (1997). Sodium valproate and pH changes in developing limb buds. (Reproducive Toxicology, in press).
63. Haghighat, N. and McCandless, D.W. (1997) Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cells. Metabolic Brain Disease, 12 (4) 287-298.
64. Adamolekun, B., McCandless, D.W., and Butterworth, R.F. (1997) Epidemic of seasonal ataxia in Nigeria following ingestion of the African silkwork Anaphe Venata: role of thiamine deficiency? Metabolic Brain Disease 12(4): 251-258).
65. Haghighat, N. and McCandless, D.W. (1999) Effect of alcohol on energy storage of primary astrocytes and C6-glioma in vitro. Metabolic Brain Disease, in press.
66. Haghighat, N., McCandless, D.W., and Geraminegad, P.: Responses in primary astrocytes and C6-glioma cells to ammonium chloride and Dibutyryl cyclic-AMP. Submitted.
Schenker, S., and McCandless, D.W. (1964) Renal disposition of conjugated bilirubin in aglomerular fish. Nature, 202: 1344-1245.
Schenker, S., McCandless, D.W. and Zollman, P. (1966) studies of cellular toxicity of unconjugated bilirubin in kernicteric brain. J. Clin. Invest., 45: 1213-1220.
Schenker, S., McCandless, D.W. and Wittgenstein, E. (1966) Studies in vivo of the effect of unconjugated bilirubin on hepatic phosphorylation and respiration. GUT, 7: 409-414.
Schenker, S., McCandless, D.W., Brophy, E. and Lewis, M (1967) Studies on intracellular toxicity of ammonia. J. Clin. Invest., 46: 838-848.
Shorey, J., McCandless, D.W. and Schenker, S., (1967) The role of cerebral alpha-ketoglutarate in ammonia intoxication. Gastroenterology, 53: 706-711.
McCandless, D.W. and Schenker, S. (1968) Encephalopathy of thiamine deficiency: Studies on intracerebral mechanisms. J. Clin. Invest. 57: 2268-2280.
Schenker, S., Qualls, R., Butcher, R. and McCandless, D.W. (1969) Regional renal energy metabolism in thiamine deficiency. J. Nutr. 99: 168-176.
McCandless, D.W., and Schenker, S., Neurologic disorder of thiamine deficiency. Nutr. Reviews, 27: 213-215.
McCandless, D.W. and Schenker, S., (1970) Cardiac metabolism in thiamine deficiency. J. Nutr., 100: 991-1002.
Speeg, K., Chen, D., Hansen, C., McCandless, D.W. and Schenker, S. (1970) Cerebral acetycholine in thiamine deficiency. Proc. Soc. Exper. Biol. Med., 134: 1005-1009.
Walker, C., McCandless, D.W., McGarry, J. and Schenker, S. (1970) Cerebral energy metabolism in short chain fatty acid induced coma. J. Lab. Clin. Med., 76: 569-583.
Schenker, S., Chen, D., Speeg, V., Walker, C. and McCandless, D.W. (1971) Hepatic metabolism and transport in thiamine deficiency. Amer. J. Digest Dis., 16:255-264.
Berry, H., Cripps, R., Nicholls, K., McCandless, D.W. and Harper, C., Development of Phenylalanine hydroxylase activity in guinea pig livers. B.B.A., 261: 315-320.
Henderson, G., McCandless, D.W. and Schenker, S. (1973) Intestinal metabolism in thiamine deficiency. Proc. Soc. Exper. Biol. Med., 144: 596-602.
McCandless, D.W., Cassidy, C. and Curley, A. (1975) Thiamine deficiency and the hepatic pentose phosphate cycle. Biochem. Med. 14: 384-390.
McCandless, D.W., Malone, M. and Szoke, M., Pyrithiamine-induced thiamine deficiency: Effects on rat myelination. Internat. J. Vit. Nutr. Res., 46: 24-30.
McCandless, D.W., Rosberg, N. and Cassidy, C. (1976) Brain Chopping: A new method for the rapid removal of newborn rat brain. Experientia, 32: 669-670.
McCandless, D.W. and Cassidy, S. (1976) Adenine nucleotides in thiamine deficient rat brain. res. Comm. Chem. Path. Pharm., 14: 579-582.
McCandless, D.W., Curley, A. and Cassidy, C. (1976) Thiamine deficiency and the pentose phosphate cycle in rats: Intracerebral mechanisms. J. Nutr. 106: 1144-1151.
Schwartz, J., and McCandless, D.W. (1976) Glycolytic metabolism in cultured cells of the nervous system IV, The effects of thiamine deficiency on thiamine levels, metabolites, and enzymes of the C-6 glioma and C-1300 neuroblastoma cell lines. Molec. and Cell. Biochem., 13: 49-53.
McCandless, D.W., Curley, A. and Cassidy, C. (1976) Cardiac and renal pentose phosphate pathway activity in thiamine deficiency. Internat. J. Vit. Nutr. Res., 46: 297-302.
McCandless, D.W. and Hodgkin, W.A. (1977) Subacute necrotizing encephalomyelopathy. Pediatrics 60: 935-936.
McCandless, D.W., Feussner, G., Lust, W.D. and Passonneau, J.V. (1979) Metabolite levels in brain following experimental seizures: The effects of electroshock and phenytoin in cerebellar layers. J. Neurochemistry, 32: 743-754.
McCandless, D.W., Feussner, G., Lust, W.D. and Passonneau, J.V. (1979) Metabolite levels in brain following experimental seizures: The effects of isoniazid sodium valproate in cerebellar and cerebral cortical layers. J. Neurochemistry, 32: 755-760.
McCandlethe National Academy of Sciences 76: 1482-1484.
McCandless, D.W. (1980) Brain chopping as a method for rapid removal and fixation of deep brain structures. IN: Cerebral Metabolism and Neural Function. (J.V. Passonneau, ed.), Williams and Wilkins, pp. 49-53.
McCandless, D.W. and Abel, M. (1980) The effect of unconjugated bilrubin on regional cerebellar energy metabolism. Neurobehav. Toxicology, 2: 81-84.
Schenker, S., Henderson, G., Hoyumpa, A.M. and McCandless, D.W. (1980) Hepatic and Wernicke's encephalopathies: Current concepts of pathogenesis. Amer. J. Clin. Nutr., 33: 2719-2726.
McCandless, D.W. and Scott, W.J. (1981) The effect of 6-aminonicotinamide on energy metabolites in neural tubes of developing embryos. Teratology, 23: 391-396.
McCandless, D.W. (1981) Insulin induced hypoglycemia coma and regional cerebral energy metabolism. Brain Research, 215: 225-234.
McCandless, D.W. and Schenker, S. (1981) Effect of acute ammonia intoxication on energy stores in the cerebral reticular activating system. Exp. Brain Res., 44: 325-334.
McCandless, D.W. and Schwartzenberg, F. (1981) Chronic thiamine deficiency and energy metabolism in dieter's nucleus. Res. Comm. Psychol., Psychiat., and Behav., 6: 183-193, 1981.
McCandless, D.W. (1981) The turnover of energy metabolites in the ascending reticular activating system in ammonia induced coma. Neurobehav. Toxicol., 3: 257-260.
McCandless, D.W. and Wiggins, R. (1981) Cerebral energy metabolism during the onset and recovery from haolothane anesthesia. Neurochem. Res., 6: 1319-1326.
Feussner, G., Lust, W.D., McCandless, D.W. and Passonneau, J.V. (1981) The differential response of cyclic nucleotides in cerebellar layers following decapitation. J. Cyc. Nuc. Res. 7: 333-337.
McCandless, D.W. (1982) Energy metabolites in the lateral vestibular nucleus in thiamine deficiency. Ann. N.Y. Acad. Sci. 378: 355-364.
McCandless, D.W. and Schwartzenburg, F.C. (1982) Pentylenetetrazole induced changes in cerebellar energy metabolism. Neurochemical Res., 7: 811-189.
Abel, M., and McCandless, D.W. (1982) The effect of bilateral ischemia on energy metabolites in the mongolian gerbil hippocampus and dentate gyrus. Neurochemical Research, 7: 789-797.
McCandless, D.W., Abel, M. and Scwartzenburg, F.C. (1982) Isonazid induced seizures and cerebral cortical and cerebellar energy metabolism. J. Neurosci. Res., 7: 419-430.
McCandless, D.W. and Schwartzenburg, F.C. (1982) Audiogenic seizure induced changes in energy metabolites in cerebral cortical and cerebellar layers. Epilepsia, 23: 481-489.
McCandless, D.W., Abel, M. and Stavinoha, W. (1984) The maintenance of regional chemical integrity for energy metabolites in microwaved mouse brain. Brain Res. Bull., 13: 253-255.
Sears. E.S., McCandless, D.W. and Chandler, M.D. (1985) Disruption of the blood brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluromethyl ornithine. J. Neurosci. Res., 14: 255-261.
McCandless, D.W. (1985) Octanoic Acid induced coma and reticular formation energy metabolism. Brain Res., 335: 131-137.
McCandless, D.W., Looney, G.A., Modak, A.T. and Stavinoha, W.B. (1985) Cerebral acetycholine and energy metabolism changes in acute ammonia intoxication in the lower primate Tupaia Glis. J. Lab. Clin. Med., 106: 183-186.
McCandless, D.W. and Looney, G.A. (1985) Sodium Valproate and cerebral energetics. Neurochem. Res., 10: 1429-1437.
Lockwood, A.H. and McCandless, D.W. (1986) Letter Re hepatic encephalopathy, Fraser, C.L. and Arieff, A.I. New England J. Med. 314: 785.
McCandless, D.W., DeFrance, J.F., Dworsky, S. and Presley, E. (1986) Status Epilpeticus in induced changes in primate cortical energy metabolism. Amer. J. Physiol. 251: 744-749.
Dworsky, S. and McCandless, D.W. (1987) Regional cerebral energy metabolism in bicuculline induced seizures. J. Neurochem. Res., 12: 237-240.
McCandless, D.W., Dworsky, S., Modak, A.T. and Stavinoha, W.B. (1987) Pentylenetetrazole-induced seizures alter cerebral energy metabolism in the lower primate, Tupaia Glis. Epilepsia, 28: 184-189.
Collins, R.C., McCandless, D.W. and Wagman, I.L. (1987) Cerebral glucose utilization: Comparison of 6-14C-glucose and 14-C-deoxyglucose quantitative autoradiography. J. Neurochem. 49: 1564-1570.
Grotta, J.C., Pettigrew, L.C., Rosenbaum, D., Reid, C., Rhoades, H., and McCandless, D.W. (1988) Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats. Stroke 19: 447-454.
Pettigrew, L.C., Grotta, J.C., Rhoades, H.M., Reid, C., and McCandless, D.W. (1988) Reginal depletion of adenosine triphosphate, phosphocreatine, and glucose in ischemic hippocampus. Metabolic Brain Disease. 3: 185-200.
DeFrance, J. and McCandless, D.W. (1991) Energy Metabolism in Rat Hippocampus During and Following Seizure Activity, Met. Brain Dis., 6:83-91
Abel, M.S. and McCandless, D.W. (1992) Elevated GABA levels attenuate the metabolic response to bilateral ischemia. J. Neurochem, 58:740-744.
O'Flaherty, E., Nan, H., McCandless, D.W., Beliles, R., Schreiner, C., and Scott, W. (1995) Physiologically-based pharmacokinetics of methoxyacetic acid: Dose-effect considerations in C57BL/6 mice. Teratology 52: 78-89.
Schreiner, C.M., Collins, M., Scott, W., Vorhees, C., Colvin, J. and McCandless, D.W. (1995) Estimating intracellular pH in developing rodent embryos using a computer imaging technique: Changes in embryonic pH and proliferation rates following maternal treatment with acetazolamide. Teratology 52: 160-168.
1. McCandless, D.W., Lust, W.D., Fuessner, G. and Passonneau, J.V. (1979) Mechanism of action of Phenytoin: Evidence for a cerebellar locus. IN: Pathophysiology of Cerebral Energy Metabolism. (B.B. Mrsulja, ed.), Plenum Press, pp. 391-402.
2. Passonneau, J.V., Lust, W.D. and McCandless, D.W. (1980) Fixation and extraction of viable tissues. IN: Techniques in Metabolic Research. (C. Pogson, ed.), Elsevier Publishing Co., pp. 1-27.
3. Lust, W.D., Feussner, G., Passonneau, J. and McCandless, D.W. (1981) The effect of anticonvulsants on cyclic nucleotide metabolism in Brain. IN: Neuropharm. of Central Disorders. Academic Press, NY.
4. McCandless, D.W. (1985) Thiamine deficiency and cerebral energy metabolism. IN: Cerebral energy metabolism and metabolic encephalopathy, (D.W. McCandless, ed.) Plenum Publishing Corp. NY, NY, pp. 335-351.
5. McCandless, D.W. and Abel, M.S. (1985) Hypoglycemia and cerebral energy metabolism. IN: Cerebral energy metabolism and metabolic encephalopathy. (D.W. McCandless, ed.) Plenum Publishing Corp., NY, NY, pp. 27-41.
6. McCandless, D.W. (1985) The development of ancillary carbohydrate metabolism pathways in mammalian brain. IN: Developmental Neurohistochemistry (R.C. Wiggins, D.W. McCandless and S.J. Enna, eds.) University of Texas Press, Austin, TX.
7. Schenker, S. and McCandless, D.W. (1986) Bilirubin toxicity and kernicterus. IN: Bile Pigments and Jaundice (J.D. Ostrow, ed.) Dekker and Co., NY, NY.
8. Dworsky, S., Namovic, M., and McCandless, D.W. (1989) High energy phosphates in brain from dissected freeze dried regions to single cells. IN: Neurochemical Methods, (R. Butterworth, ed.) Humana Press, Baltimore.
9. Pettigrew, L.C., Arieff, A.I., and McCandless, D.W. (1992) CNS Manifestations of Hypoglycemia. IN: Metabolic Brain Dysfunction in Systemic Disorders, (A. Arieff, ed.) Little Brown & Lo, Boston, pp. 129-139.
10. Abel, M.S., and McCandless, D.W.(1992) The Kindling Model of Epilepsy. IN: Animal models of Neurological Disease II, (Boulton, Baker and Butterworth, eds.) Humana Press, Baltimore, pp. 153-168.
11. McCandless, D.W. and FineSmith, R.B.(1992) Animal Models of Experimental Seizures. IN: Animals Models of Neurological Disease II, (Boulton, Baker and Butterworth, eds.) Human Press, Baltimore, pp. 133-150.
12. McCandless, D.W. and Abel, M.S. (1992) Genetically-based animal models of seizures. IN: Animals Models of Neurological Disease II, (Boulton, Baker and Butterworth, eds.) Humana Press, Baltimore, pp.169-182.
13. Seta, K.A., Crumrine,C., Whittingham, T.S., Lust, W.D. and McCandless, D.W. (1992) Experimental Models of Human Stroke. IN: Animals Models of Neurological Disease II, (Boulton, Baker and Butterworth, eds.) Humana Press, Baltimore, pp.1-40.
14. Schreiner, C.M., Scott, W.J., Collins, M.D., Colvin, J., and McCandless, D.W. (1993) Estimation of intracellular pH by computer assisted imaging in the developing mouse forelimb bud exposed to acetazolamide. IN: Limb Development and Regeneration, Wiley-Liss, Inc., pp. 403-408.
15. Schreiner, C.M., Scott, W.J., Collins, M.D., Colvin, J., and McCandless, D.W. (1993) Estimation of intracellular pH by computer assisted imaging in the developing mouse forelimb bud exposed to acetazolamide. IN: Limb Development and Regeneration, Wiley-Liss, Inc., pp. 403-408.
16. McCandless, J.W. and McCandless, D.W. (2009) Bilirubin Encephalopathy. IN: Metabolic
Encephalopathy, Springer Publ., NY, NY.
1. McCandless, D.W., ed. (1985) Cerebral Energy Metabolism and Metabolic Encephalopathy, Plenum Press, NY, NY.
2. Wiggins, R.C., McCandless, D.W. and Enna, S.J., eds. (1985) Developmental neurochemistry, Univ.Texas Press, Austin, TX.
3. McCandless, D.W., ed. (2009) Metabolic Encephalopathy, Springer Publ., NY, NY.
4. McCandless, D.W., (2010) Thiamine Deficiency and Associated Clinical Disorders. Springer NY, NY.
5. McCandless, D.W., (in press) Kernicterus. Springer, NY, NY, projected date 2011