Robert A. Marr Publications

Faculty Directory

Marjorie A. Ariano, Ph.D.
Professor of Neuroscience
Associate Dean, Undergraduate Studies
Room 1.330
Telephone (847) 578-3412

Lise S. Eliot, Ph.D.
Associate Professor, Room 2.274
Telephone (847) 578-3416

Robert Marr, Ph.D.
Assistant Professor, Room 2.212
Telephone (847) 578-8541

Daniel A. Peterson, Ph.D.
Associate Professor, Room 2.217B
Telephone (847) 578-3411

Grace E. Stutzmann (Beth), Ph.D.
Assistant Professor, Room 2.216
Telephone (847) 578-8540

Anthony R. West, Ph.D.
Associate Professor, Room 2.217A
Telephone (847) 578-8658

Marina E. Wolf, Ph.D
Professor and Chair, Room 2.262
Telephone (847) 578-8659

Dr. Robert A. Marr,
Assistant Professor

Research Projects • Publications • Lab Members • Marr Home

PUBLICATIONS

F Klempin, RA Marr, DA Peterson (2011). "Modification of Pax6 and Olig2 in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations." Stem Cells, in press.

JY Huang, DM Hafez, BD James, DA Bennett, RA Marr^† (2011). Altered NEP2 expression and activity in mild-cognitive impairment and Alzheimer’s disease. Journal of Alzheimer’s Disease, In press.

A Bruno, J Huang, DA Bennett, RA Marr, GE Stutzmann, and M Hastings (2011). Altered Ryanodine Receptor Expression in Mild Cognitive Impairment and Alzheimer's Disease. Neurobiology of Aging, doi:10.1016/j.neurobiolaging.2011.03.011. PMID: 21531043

BJ Spencer, RA Marr, R Gindi, R Potkar, S Michael, A Adame, E Rockenstein, IM Verma, E Masliah (2011). Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aß Toxicity in a Mouse Model Of Alzheimer's Disease. PLoS One, e16575. PMID: 21304989

A Gadadhar, RA Marr, O Lazarov (2011). Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. Journal of Neuroscience, 31(7):2615-23. PMID: 21325529

D Hafez, JY Huang, AM Huynh, S Valtierra, E Rockenstein, AM Bruno, B Lu, L DesGroseillers, E Masliah, RA Marr^† (2011). Neprilysin-2 is an important beta-amyloid degrading enzyme. American Journal of Pathology. 178(1): 306-312. PMID: 21224067

LR Hanson, D Hafez, AL Svitak, RB Burns, X Li, WH Frey, and RA Marr^† (2010). Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2 deficient mice. Journal of Molecular Neuroscience. 178(1): 306-312. PMID: 20941644

RA Marr, RM Thomas, and DA Peterson (2010). Insights into neurogenesis and aging: Potential therapy for degenerative disease? Future Neurology, 5(4): 527-541. PMID: 20806052

RA Marr^† and BJ Spencer (2010). NEP-like endopeptidases and Alzheimer’s disease. Current Alzheimer’s Research, 7:223-229. PMID: 20088804

O Lazarov, RA Marr (2009). Neurogenesis and Alzheimer's disease: At the crossroads. Experimental Neurology, 223:267-281. PMID: 19699201

J Rose, L Crews, E Rockenstein, A Adame, M Mante, L Hersh, FH Gage, B Spencer, R Potkar, R Marr, and E Masliah (2009). Neuropeptide Y Fragments Derived from Neprilysin Processing are Neuroprotective in a Transgenic Model of Alzheimer's Disease. Journal of Neuroscience, 29(4):1115–1125. PMID: 19176820

B Spencer , RA Marr , E Rockenstein , L Crews , A Adame , R Potkar , C Patrick , FH Gage , IM Verma and E Masliah (2008). Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience, 9:109. PMID: 19014502

JY Huang, AM Bruno, CA Patel, AM Huynh, KD Philibert, MJ Glucksman, RA Marr^† (2008). Human membrane metallo-endopeptidase-like protein (MMEL) degrades both Ab₄₂ and Ab₄₀. Neuroscience, 155(1):258-62. PMID: 18571334

SS El-Amouri, H Zhu, J Yu, R Marr, IM Verma, MS Kindy (2008). Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease. Am J Pathol. 172(5):1332-1344. PMID: 18403590

B Spencer, E Rockenstein, L Crews, R Marr, E Masliah (2007). Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 7(12):1853-67. PMID: 18034651

I Hovatta, RS Tennant, R Helton, RA Marr, O Singer, JM Redwine, EE Schadt, JA Ellison, IM Verma, DJ Lockhart and C Barlow (2005). Glyoxalase 1 and glutathione reductase regulate anxiety in inbred mouse strains. Nature 438(7068):662-6. PMID: 16244648

RA Marr*, O Singer*, E Rockenstein, L Crews, NG Coufal, FH Gage, IM Verma, and E Masliah (2005). Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience8(10):1343-9. PMID: 16136043

* both authors contributed equally

JC Dodart, RA Marr, M Koistinaho, BM Gregersen, S Malkani, IM Verma, SM Paul(2005). Gene delivery of human apolipoprotein E alters brain Ab burden in a mouse model of Alzheimer’s disease. Proc. Natl. Acad. Sci. U S A 104(4):1211-1216. PMID: 15657137

M Hashimoto, E Rockenstein, M Mante, L Crews, P Bar-On, FH Gage, R Marr, and E Masliah (2004). An antiaggregation gene therapy strategy for Lewy body disease utilizing b-synuclein lentivirus in a transgenic model. Gene Therapy 11(23): 1713-1723. PMID: 15483670

HM Kankkonen, E Vähäkangas, RA Marr, T Pakkanen, A Laurema, P Leppänen, J Jalkanen, IM Verma, S Ylä-Herttuala (2004). Long-term lowering of serum cholesterol levels in LDL-receptor deficient WHHL rabbits by gene therapy. Molecular Therapy, 9(4):548-556. PMID: 15093185

RA Marr, H Guan, E Rockenstein, M Kindy, FH Gage, I Verma, E Masliah, LB Hersh (2004). Neprilysin regulates amyloid-b peptide levels. Journal of Molecular Neuroscience 22(1-2):5-11. PMID: 14742905

RA Marr, E Rockenstein, A Mukherjee, MS Kindy, LB Hersh, FH Gage, IM Verma, and E Masliah (2003). Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. Journal of Neuroscience 23(6):1992-1996.^# PMID: 12657655

Z Chen, H Huang, T Chang, S Carlsen, A. Saxena, R Marr, Z Xing, J Xiang (2002). Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor. Cancer Gene Therapy 9(9): 778-786. PMID: 12189528

J Gauldie, PJ Sime, Z Xing, B Marr, and GM Tremblay (1999). TGFß gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis. Current Topics in Pathology93: 35-45. PMID: 10339897

RA Marr, M Hitt, J Gauldie, WJ Muller, and FL Graham (1999). A p75 TNF receptor specific mutant of murine TNFa expressed from an adenovirus vector induces an antitumour response with reduced toxicity. Cancer Gene Therapy 6(5): 465-474. PMID: 10505857

PJ Sime, RA Marr, D Gauldie, Z Xing, BR Hewlett, FL Graham, and J Gauldie (1998). Transfer of tumour necrosis factor-alpha to rat lung induces severe pulmonary inflamation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts. American Journal of Pathology 153(3): 825-832. PMID: 9736031

RA Marr, M Hitt, WJ Muller, J Gauldie, and FL Graham (1998). Tumour therapy using adenovirus vectors expressing human TNFa. International Journal of Oncology 12(3): 509-515. PMID: 9472086

XF Lei, Y Ohkawara, MR Stampfli, C Mastruzzo, RA Marr, D Snider, Z Xing, and M Jordana (1998). Disruption of antigen-induced inflammatory responses in CD40 ligand knock out mice. Journal of Clinical Investigations 101(6): 1342-1353. PMID: 9502776

RA Marr, CL Addison, D Snider, WJ Muller, J Gauldie, and FL Graham (1997). Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNFa. Gene Therapy 4(11): 1181-1188. PMID: 9425441

^†corresponding author

^# featured in The Lancet 361:1107 and Drug Discovery Today 8(11): 474

Invited Book Chapters

1. Marr, RA (2011). MS: 133 | Neprilysin-2. In Handbook of Proteolytic Enzymes, 3^rd edition, ND Rawlings and G Salvesen, eds, Elsevier, pp. TBA