Research Interests
Publications
Experience, Links
Wu, J.Y. and Potashkin, J.A., (2009) Alternative splicing in the nervous system. Encyclopedia of Neuroscience, (L.R. Squire, Editor). Oxford: Academic Press. 1:245-251. Zhou L, Qi X, Potashkin JA, Abdul-Karim FW, Gorodeski GI. (2008) Micro-RNAs miR-186 and miR-150 downregulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript. J Biol Chem. 283:28274-28286. Epub 2008 Aug 5 Meredith GE, Totterdell S, Potashkin JA, Surmeier DJ. (2008) Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol. Parkinsonism Relat Disord. 14 Suppl 2:S112-5. Epub 2008 Jun 27. Potashkin JA, Kang UJ, Loomis PA, Jodelka FM, Ding Y, Meredith GE. (2007) MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9. Brain Res. 1182:1-10. Epub 2007 Sep 14. Marinescu V, Loomis PA, Ehmann S, Beales M, Potashkin JA. (2007) Regulation of retention of FosB intron 4 by PTB. PLoS ONE. 2007 Sep 5;2(9):e828. Li X, Qi X, Zhou L, Catera D, Rote NS, Potashkin J, Abdul-Karim FW, Gorodeski GI. (2007) Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells. Gynecol Oncol. 106:233-243. Epub 2007 May 4. Alibhai IN, Green TA, Potashkin JA, Nestler EJ. (2007) Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studies. Brain Res. 1143:22-33. Epub 2007 Jan 27. Potashkin JA, and Meredith GE. (2006) The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease. Antioxid. Redox. Signal. 8:144-151. Wood, V., ... Potashkin, J., ... and Nurse, P. (2002) The genome sequence of Schizosaccharomyces pombe. Nature 21:871-880. Ochotorena, I. L., Hirata D., Kominami K., Potashkin J., Sahin F., Wentz-Hunter K., Gould K. L., Sato K., Yoshida Y., Vardy L., and Toda T. (2001) Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation. J. Cell Sci. 114:2911-2920. Käufer, N. F. and Potashkin, J. (2000) Analysis of the splicing machinery in fission yeast: a comparison with budding yeast and mammals. Nucl. Acids Res. 28:3003-3010. Mayes, A. E., Potashkin, J. and Beggs, J. (2000) Splicing of pre-mRNA introns. In The Frontiers in Molecular Biology Series: The Yeast Nucleus, Eds. P. Fantes and J. D. Beggs, IRL Press, Oxford. Beales, M., Flay, N., McKinney, R., Habara, Y., Ohshima, Y. Tani, T., and Potashkin, J. (2000) Mutations in the large subunit of U2AF disrupt pre-mRNA splicing, cell cycle progression and nuclear structure. Yeast 16:1001-10013. Potashkin, J, Kim, D, Fons, M, Humphrey, T and Frendewey, D. (1998) Cell division cycle defects associated with fission yeast pre-mRNA splicing mutants. Curr. Genet. 34:153-163. Gozani, O., Potashkin, J. and Reed, R. (1998) Recruitment of U2 snRNP to the branchpoint sequence via direct interactions with U2AF. Mol. Cell. Biol. 18:4752-4760. McKinney, R., Wentz-Hunter, K., Schmidt, H., and Potashkin, J. (1997)Molecular characterization of a novel fission yeast gene spUAP2 that interacts with the splicing factor spU2AF59. Curr. Genet. 32:323-330. Wentz-Hunter, K. and Potashkin, J. (1996) The small subunit of the splicing factor U2AF is conserved in fission yeast. Nucl. Acids Res. 24:1849-1854. Wentz-Hunter, K. and Potashkin, J. (1995) The evolutionary conservation of the splicing apparatus between fission yeast and man. Nucleic Acids Symposium Series 33:226-228. Potashkin, J., Naik, K. and Wentz-Hunter, K. (1993) U2AF homolog required for splicing in vivo. Science 262:573-575.