Dominik M. Duelli, Ph.D.
Assistant Professor       
Department of Pathology
The Chicago Medical School
3333 Green Bay Road
North Chicago, Illinois 60064
email: Dominik.Duelli@rosalindfranklin.edu
PHONE (847) 578-8341
FAX (847) 578-3253
For more information:
http://www.duelli.li/duelli_lab/Index.html

B.S. Biochemistry & Biophysical Chemistry, University of Pittsburgh, Pittsburgh, PA, 1992
Ph.D. Biology, Marquette University, 1998
Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1999-2007
Assistant Professor, Pathology Department, Chicago Medical School, 2007. Rosalind Franklin University, North Chicago, IL 2008

(© Max S. Gerber)

Teaching
CMS: Department of Pathology, lecturer in Sophomore Pathology Course: series of Molecular Basis of Neoplasia and Molecular Horizons in Cancer Biology.
IGPBS: Department of Cell Biology and Anatomy, lecturer in GIGP 505: Cellular and Molecular Developmental Biology: series of Apoptosis in Development; lecturer in GCVA 604: Techniques in Cell Biology. Department of Microbiology and Immunology, lecturer in GMIC 606 Cancer Biology and Signaling: guest lecture for Genome Instability in Cancer.

The Duelli Lab
Research Interests
Our laboratory’s mission is to contribute to reducing cancer incidence. We do so with two foci in basic molecular pathology. One is to develop methods for early detection of abnormal cells using sensitive and noninvasive methods. The other focus is to understand the process of malignant conversion of tumors.

Early Detection
Cancer deaths, including mortality due to breast cancer can be prevented by early detection. We are developing a method that is non-invasive and sensitive for early diagnosis of abnormal mammary epithelia. We are developing this method to detect neoplasms by miRNA profiling of vesicles that are released from mammary epithelia into body fluids. This project is supported by the Department of Defense Breast Cancer Research Program (BCRP).

Malignant Conversion
The pathology of pre-malignant tumor progression into solid cancers is often marked by a transient tetraploidization event. We are conducting research to understand the causes tetraploidization, and how tetraploidization contributes to cancer development, with the ultimate aim to find therapies to prevent tumor progression. This project is supported by the Illinois Chapter of the American Cancer Society.

Publications
 

Pigati L, Yaddanapudi S.C.S., Iyengar R, Kim D, Hearn S, Danforth D, Hastings ML, and Duelli DM. Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells. PLoS One. 2010 Oct 20;5(10):e13515. PMID: 20976003
Jodelka F, Ebert A, Duelli DM, Hastings M. A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Human Molecular Genetics. 2010 Oct 13. [Epub ahead of print]. PMID: 20884664
Duelli D and Lazebnik Y. (2007) Cell-to-cell fusion as a link between viruses and cancer. Nature Reviews Cancer. 7(12): 968-976.
Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR (2007) Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF. PLoS ONE 2: e538. PMID: 17579712
Duelli DM, Padilla-Nash H, Berman D, Murphy KM, Ried T, Lazebnik Y (2007) A virus causes cancer by inducing massive chromosomal instability through cell fusion. Current Biology 17 (5): 431-437. PMID: 17320392
Selected for Research Highlights, Nature Reviews Cancer 7, 230, Nature Reviews Microbiology, 5, 244, 2007, Comment in New Scientist 12, 2593, 200.7
Duelli DM, Hearn S, Myers MP, Lazebnik Y (2005) A primate virus generates transformed human cells by fusion. Journal of Cell Biology 171 (3): 493-503. PMID: 16275753
Selected for Research Highlights, Nature 438, 260-261 & Vile RG, News and Commentary, Gene Ther. 2006 13, 1127-30.
Duelli D and Lazebnik Y (2003) Cell fusion: A hidden enemy? Cancer Cell 3 (5):445-448. PMID: 12781362
Duelli DM, Tobin A, Box JM, Kolli VS, Carlson RW, Noel KD (2001) Genetic locus required for antigenic maturation of Rhizobium etli CE3 lipopolysaccharide. Journal of Bacteriology 183 (20): 6054-6064. PMID: 11567006
Duelli DM and Lazebnik YA (2000) Primary cells suppress oncogene-dependent apoptosis. Nature Cell Biology 2 (11): 859-862. PMID: 11056544
Duelli DM and Noel KD (1997) Compounds exuded by Phaseolus vulgaris that induce a modification of Rhizobium etli lipopolysaccharide. Mol. Plant-Microbe Interact. 10: 903-910.
Noel KD, Duelli DM, Tao H, Brewin NJ (1996) Antigenic change in the lipopolysaccharide of Rhizobium etli CFN42 induced by exudates of Phaseolus vulgaris. Mol. Plant-Microbe Interact. 9:180-186.
Noel KD, Duelli DM, Tao H, Brewin NJ (1996) Antigenic change in the lipopolysaccharide of Rhizobium etli CFN42 induced by exudates of Phaseolus vulgaris.  Mol. Plant-Microbe Interact. 9:180-186.