Kenneth D. Beaman, Ph.D.

Professor and Director,
Clinical Immunology Lab
Room 2.238
Building: BS
Phone: (847) 578-3449
E-mail: kenneth.beaman@rosalindfranklin.edu

Biography

Dr. Kenneth Beaman received his Bachelors Degree in 1975 from Colorado State University. He was a fellow in the Clinical Microbiology Lab at the Cleveland Clinic Foundation from 1975 to 1978. He received his Ph.D. from the Ohio State University in Microbiology and Immunology in 1982. He was a postdoctoral fellow in the Department of Pathology at Yale from 1982 to 1985. During his fellowship at Yale University he was a member of the transplantation laboratory. His research interests are in clinical immunology and in immune suppression, particularly during pregnancy. In 1985, he joined the Department of Microbiology and Immunology at the Chicago Medical School. He founded the Clinical Immunology Laboratory at the Chicago Medical School in 1987. The Clinical Immunology Laboratory supports a variety of autoimmune/rheumatology testing but primarily is interested in diagnostic tests pertaining to the immunology of pregnancy. Dr. Beaman is a fellow of the American Association of Medical Laboratory Immunologists and a Diplomat of the American Board of Medical Laboratory Immunology. The Clinical Immunology Laboratory is one of three laboratories in the United States certified by the Committee on Postdoctoral Educational Program (CPEP) approved postdoctoral training in Clinical Immunology that is accredited by the American Society of Microbiology. He is on the council of several national and international societies of both Reproductive and Clinical Immunology.

Director, Clinical Immunology Laboratory

The Clinical Immunology Laboratory performs over 1.3 million diagnostic tests for national and international clinics and physicians per year. 

The Clinical Immunology Laboratory at Rosalind Franklin University was established in 1988 as a pioneering laboratory specializing in cutting-edge immunological tests. It was one of the first to provide immunological testing for the diagnosis of recurrent pregnancy losses and unexplained infertility. The laboratory offers innovative immune assays, using both immunological and molecular biology methodology and state-of-the-art instruments. It provides services to physicians and patients nationally and internationally.

The laboratory, being part of Rosalind Franklin University of Medicine and Science, has performed scientific research in the field of human reproduction for over two decades and has been established as a leading center in the area of reproductive immunology. The laboratory serves local and national and international physicians and patients with the implementation of new diagnostic assays. In 1997, the Clinical Immunology Laboratory at Rosalind Franklin University established one of 3 Programs in the United States that is certified by the American Academy of Microbiology to educate postdoctoral students that are eligible for the American Board of Medical Laboratory Immunology. American Board of Medical Laboratory Immunology certifies the expertise of doctoral-level immunologists seeking to direct laboratories engaged in the practice of medical laboratory immunology. ABMLI certification is recognized by federal and state governmental agencies as a significant component toward meeting licensure requirements to direct laboratories engaged in the microbiological diagnosis of human disease. It is recognized under the Clinical Laboratory Improvement Amendments of 1988 final rule. There are 13 fellows educated through the program and are directors of Clinical laboratories throughout the US and Canada several others have come to the program as part of Sabbatical leaves to study at the Laboratory. These students are on faculty of many International Universities and are listed in students section above. The Clinical Laboratory provided services in flow cytometry for the Departments of Microbiology and Immunology, Pathology, Podiatry and Medicine.

Research Interests

The immune response to tumors and pregnancy is unique. In both cases the initial immune response is absent as measured by standard techniques such as the mixed lymphocyte reaction. This is thought to be due to the absence of HLA antigen on trophoblasts or tumors during a portion of their growth cycle. However, when other parameters are measured, unique immunological mechanisms can be seen, such as unique populations of mononuclear cells as well as a unique cytokine milieu associated with the tissue. 

General hypothesis: under certain stressful developmental conditions such as low pH and tumor growth, the first initiation of the immune response may be cytokine production and not antigen recognition. This cytokine production can precede antigen recognition by either the innate or adaptive immune response. This production of cytokines regulates the immune response both independent of and prior to antigen recognition by creating a unique environment for later antigen driven development.

Selected Publications

Jaiswal MK, Mallers TM, Kwong C, Chaouat G, Gilman-Sachs A, Beaman KD. Abortion-Prone Mating Influences Alteration of Systemic a2 Vacuolar ATPase Expression in Spleen and Blood Immune Cells. Am J Reprod Immunol. 2012 Jan 6. 67(5) 421-33.

Jaiswal MK, Gilman-Sachs A, Chaouat G, Beaman KD. Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice. Biol Reprod.2011 Sep;85(3):626-34.

Kwong C, Gilman-Sachs A, Beaman K. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011 Feb 1;186(3):1781-9. 

Jaiswal MK, Mallers TM, Kwong C, Chaouat G, Gilman-Sachs A, Beaman KD. Abortion-Prone Mating Influences Alteration of Systemic a2 Vacuolar ATPase Expression in Spleen and Blood Immune Cells. Am J Reprod Immunol. 2012 Jan 6. 67(5) 421-33. 

Beaman KD, Ntrivalas E, Mallers TM, Jaiswal MK, Kwak-Kim J, Gilman-Sachs A,  Immune etiology of recurrent pregnancy loss and its diagnosis. Am J Reprod Immunol. 2012 Apr;67(4):319-25. 

Jaiswal MK, Mallers TM, Larsen B, Kwak-Kim J, Chaouat G, Gilman-Sachs A, Beaman KD., V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012 May;143(5):713-25. 

Kwong C, Gilman-Sachs A, Beaman K. An independent endocytic pathway stimulates different  monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase. OncoImmunology 2013 2:1 e22978-1 - e22978-10

Updated: 11.20.2014

 

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