Russell Dahl, PhD

Associate Professor, Pharmaceutical Sciences
College of Pharmacy
Associate Professor, Neuroscience
Chicago Medical School
Building: IPEC
Room: 2.807
Lab: 1.354
Phone: 847-578-3433
Russell.Dahl@rosalindfranklin.edu

Recent Publications

Cornea RL, Gruber SJ, Lockamy EL, Muretta JM, Jin D, Chen J, Dahl R, Bartfai T, Zsebo KM, Gillispie GD, Thomas DD. High-Throughput FRET Assay Yields Allosteric SERCA Activators. J. Biomol. Screen. (2012) in press, doi:10.1177/1087057112456876.

Kiffer-Moreira T, Yadav MC, Zhu D, Narisawa S, Sheen C, Stec B, Cosford ND, Dahl R, Farquharson C, Hoylaerts MF, Macrae VE, Millán JL. Pharmacological inhibition of PHOSPHO1 suppressesvascular smooth muscle cell calcification. J Bone Miner. Res. (2012) in press, doi: 10.1002/jbmr.1733.

Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC. Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev. (2012) 26, 1041-54.

Julia I. Toth, Li Yang, Russell Dahl, Matthew D. Petroski. A Gatekeeper Residue for NEDD8-Activating Enzyme Inhibition by MLN4924. Cell Rep. (2012) 1, 309-316.

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L. LYP inhibits T-cell activation when dissociated from CSK. Nature Chem. Bio. (2012) 8, 437-446.

Si Wang, William J. Placzek, John L. Stebbins, Sayantan Mitra, Roberta Noberini, Mitchell Koolpe, Ziming Zhang, Russell Dahl, Elena B. Pasquale, and Maurizio Pellecchia. Novel Targeted System To Deliver Chemotherapeutic Drugs to EphA2-Expressing Cancer Cells. J. Med. Chem. (2012) 55, 2427–24361.

Albert G. Remacle, Vladislav S. Golubkov, Sergey A. Shiryaev, Russell Dahl, John L. Stebbins, Andrei V. Chernov, Anton V. Cheltsov, Maurizio Pellecchia and Alex Y. Strongin. Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. (2012) 72, 2339-2349.

Russell Dahl, Yalda Bravo, Vandana Sharma, Mie Ichikawa, Raveendra-Panickar Dhanya, Michael Hedrick, Brock Brown, Justin Rascon, Michael Vicchiarelli, Arianna Mangravita-Novo, Li Yang, Derek Stonich, Ying Su, Layton H. Smith, Eduard Sergienko, Hudson H. Freeze, Nicholas D. P. Cosford. Potent, Selective, and Orally Available Benzoisothiazolone Phosphomannose Isomerase Inhibitors as Probes for Congenital Disorder of Glycosylation Ia. J. Med. Chem. (2011) 54, 3661–3668.

Zhai D, Godoi P, Sergienko E, Dahl R, Chan X, Brown B, Rascon J, Hurder A, Su Y, Chung TD, Jin C, Diaz P, Reed JC. High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1. J Biomol Screen. (2011) 17, 350-360.

Sergienko E, Xu J, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L. Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation. ACS Chem Biol. (2011) 7, 367-377.

Eduard Sergienko , Jian Xu , Wallace H Liu , Russell Dahl , David Atwater Critton , Ying Su , Brock T Brown , Xochella Chan , Li Yang , Ekaterina Bobkova , Stefan Vasile , Hongbin Yuan , Justin Rascon , Sharon Colayco, Shyama Sidique , Nicholas D. P. Cosford , Thomas D.Y. Chung , Tomas Mustelin , Rebecca Page , Paul J Lombroso , and Lutz Tautz. Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation. ACS Chem. Biol. (2011) Articles ASAP, DOI: 10.1021/cb2004274

Jun Wei, John L. Stebbins, Shinichi Kitada, Rupesh Dash, Dayong Zhai, William J. Placzek, Bainan Wu, Michele F. Rega, Ziming Zhang, Elisa Barile, Li Yang, Russell Dahl, Paul B. Fisher, John C. Reed, Maurizio Pellecchia. An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins. Front. Oncol. (2011) 1, 1-14.

Vandana Sharma, Mie Ichikawa, Ping He, Yalda Bravo, Russell Dahl, Bobby Ng, D.P. Cosfor, Hudson H. Freeze. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase deficient fibroblasts. J. Biol. Chem. (2011) 286(45):39431-8.

Doug Scheffer, Anthony Pinkerton, Russell Dahl, Nicholas Cosford. Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators. ACS Chem. Neurosci. (2011) 2, 382–393.

Raveendra-Panickar Dhanya, Shyama Sidique, Douglas J. Sheffler, Hilary Highfield Nickols, Ananda Herath, Li Yang, Russell Dahl, Robert Ardecky, Svetlana Semenova, Athina Markou, P. Jeffrey Conn, and Nicholas D. P. Cosford. Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats. J. Med. Chem. (2011) 54, 342–353.

Surya K. De, Elisa Barile, Vida Chen, John L. Stebbins, Jason F. Cellitti, Thomas Machleidt, Coby B. Carlson, Li Yang, Russell Dahl and Maurizio Pellecchia. Design, synthesis, and structure–activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase. Biorg. Med. Chem. (2011) 19, 2582-2588.

Stephanie M. Stanford, Divya Krishnamurthy, Matthew D. Falk, Rossella Messina, Bikash Debnath, Sheng Li, Tong Liu, Roza Kazemi, Russell Dahl, Yantao He, Xiao Yu, Andrew C. Chan, Zhong-Yin Zhang, Amy M. Barrios, Virgil L. Woods Jr., Nouri Neamati, Nunzio Bottini. Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells. J. Med. Chem. (2011) 54, 1640-1654.

Marilisa Leone, Elisa Barile, Russell Dahl and Maurizio Pellecchia. Design and NMR Studies of Cyclic Peptides Targeting the N-Terminal Domain of the Protein Tyrosine Phosphatase YopH. Chem. Biol. Drug Des. (2011) 77, 12-19.

John R. Cashman, Mary MacDonald, Senait Ghirmai, Karl J. Okolotowicz, Eduard Sergienko, Brock Brown, Xochella Garcia, Dayong Zhai, Russell Dahl and John C. Reed. Inhibition of Bfl-1 with N-aryl maleimides. Bioorg. Med. Chem. Lett. (2010) 20, 6560-6564.

Dahl, Russell; Baldridge, Kim; Finney, Nathaniel. Efficient Access to Aminomannoside Derivatives via Formal [2+2] Cycloaddition of Triazolinediones and Tri-O-acetyl-D-glucal. Synthesis (2010), 13, 2292-2296.

Jun Wei, Shinichi Kitada, John L. Stebbins, William Placzek, Dayong Zhai, Bainan Wu, Michele F. Rega, Ziming Zhang, Jason Cellitti, Li Yang, Russell Dahl, John C. Reed, and Maurizio Pellecchia. Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J. Med. Chem. (2010) 53, 8000-8011.

Xinchun Jin, Svetlana Semenova, Li Yang, Robert Ardecky, Douglas J Sheffler, Russell Dahl, P Jeffrey Conn, Nicholas DP Cosford & Athina Markou. The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats. Neuropsychopharmacology (2010) 35, 2021-2036.

Ekaterina V. Bobkova, Wallace H. Liu, Sharon Colayco, Justin Rascon, Stefan Vasile, Carlton Gasior, David A. Critton, Xochella Chan, Russell Dahl, Ying Su, Eduard Sergienko, Thomas D. Y. Chung, Tomas Mustelin, Rebecca Page, and Lutz Tautz. Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. ACS Med. Chem. Lett. (2011) 2, 113–118.

Raveendra-Panickar Dhanya, Shyama Sidique, Douglas J. Sheffler, Hilary Highfield Nickols, Ananda Herath, Li Yang, Russell Dahl, Robert Ardecky, Svetlana Semenova, Athina Markou, P. Jeffrey Conn, and Nicholas D. P. Cosford. Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats. J. Med. Chem. (2011) 54, 342–353.

Antonio Garrido Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Justin T. Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jeff Kucharski, Christopher Lum, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Edward Roberts, Eddine Saiah, Robert Sullivan, Jan Urban, Zhijun Wang, Christopher J. Larson. Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site. Bioorg. Med. Chem. Lett. (2010) 20(16), 4819-4824.

Leone, Marilisa; Barile, Elisa; Vazquez, Jesus; Mei, Angel; Guiney, Donald; Dahl, Russel and Pellecchia, Maurizio. NMR-Based Design and Evaluation of Novel Bidentate Inhibitors of the Protein Tyrosine Phosphatase YopH. Chem. Biol. Drug. Des. (2010) 76, 10-16.

Elisa Barile, Surya K. De, Coby B. Carlson, Vida Chen, Christine Knutzen, Megan Riel-Mehan, Li Yang, Russell Dahl, Gary Chiang, and Maurizio Pellecchia. Design, Synthesis, and Structure-Activity Relationships of 3-Ethynyl-1H-indazoles as Inhibitors of the Phosphatidylinositol 3-Kinase Signaling Pathway. J. Med. Chem. (2010) 53, 8368–8375.

Jun Wei, John L. Stebbins, Shinichi Kitada, Rupesh Dash, William Placzek, Michele F. Rega, Bainan Wu, Jason Cellitti, Dayong Zhai, Li Yang, Russell Dahl, Paul B. Fisher, John C. Reed and Maurizio Pellecchia. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J. Med. Chem. (2010) 53, 4166-4176.

Ranxin Shi, Daniel Re, Eric Dud, Michael Cuddy, Karl J Okolotowicz, Russell Dahl, Ying Su, Andrew Hurder, Shinichi Kitada1, Satyamaheshwar Peddibhotla, Gregory P. Roth, Layton H. Smith, Thomas J. Kipps, Nicholas Cosford, John Cashman, John C Reed. Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activition Induced by Protein Kinase C and Antigen Receptors. ACS Chem. Biol. (2010) 5, 287–299.

Russell Dahl, Eduard A. Sergienko, Ying Su, Yalda S. Mostofi, Li Yang, Ana Maria Simao, Sonoko Narisawa, Brock Brown, Arianna Mangravita-Novo, Michael Vicchiarelli, Layton H. Smith, W. Charles O’Neill, Jose Luis Millan, Nicholas D. P. Cosford. Discovery and Validation of a Series of Arylsulfonamides as Selective Inhibitors of Tissue-Nonspecific Alkaline Phosphatase (TNAP). J. Med. Chem. (2009) 52 (21), 6919–6925.

Ananda Herath, Russell Dahl, Nicholas D. P. Cosford Fully Automated Flow Synthesis of Highly Functionalized Imidazo[1,2,a] Heterocycles. Org. Lett. (2010) 12, 412–415.

Surya K. De, Vida Chen, John L. Stebbins, Li-Hsing Chen, Jason F. Cellitti, Thomas Machleidt, Elisa Barile, Megan Riel-Mehan, Russell Dahl, Li Yang, Aras Emdadi, Ria Murphy, Maurizio Pellecchia Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg. Med. Chem. (2010), 18(2): 590-596.

A. G. Montalban, E. Boman, C.-D. Chang, S. C. Ceide, R. Dahl, D. Dalesandro, N. G. J. Delaet, E. Erb, J. T. Ernst, A. Gibbs, J. Kahl, L. Kessler, J. Lundström, S. Miller, H. Nakanishi, E. Roberts, E. Saiah, R. Sullivan, Z. Wang, C. J. Larson. KR-003048, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase Eur. J. Pharm (2009) 632, 93-102.

Jun Wei, Shinichi Kitada, Michele F. Rega, John L. Stebbins, Dayong Zhai, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Russell Dahl, Ziming Zhang, Li Yang, John C. Reed and Maurizio Pellecchia. Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. (2009) 52(14): 4511-23.

Lu, Jie; Chan, Lai; Fiji, Hannah D. G.; Dahl, Russell; Kwon, Ohyun; Tamanoi, Fuyuhiko. In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol. Cancer Ther. (2009), 8(5), 1218-1226.

Wei, Jun; Kitada, Shinichi; Rega, Michele F.; Emdadi, Aras; Yuan, Hongbin; Cellitti, Jason; Stebbins, John L.; Zhai, Dayong; Sun, Jiazhi; Yang, Li; Dahl, Russell; Zhang, Ziming; Wu, Bainan; Wang, Si; Reed, Tyler A.; Lawrence, Nicholas; Sebti, Said; Reed, John C.; Pellecchia, Maurizio. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol. Cancer Ther. (2009), 8(4), 904-913.

Wu, Bainan; Rega, Michele F.; Wei, Jun; Yuan, Hongbin; Dahl, Russell; Zhang, Ziming; Pellecchia, Maurizio. Discovery and binding studies on a series of novel Pin1 ligands. Chemical Biology & Drug Design (2009), 73(4), 369-379.

De, Surya K.; Chen, Li-Hsing; Stebbins, John L.; Machleidt, Thomas; Riel-Mehan, Megan; Dahl, Russell; Chen, Vida; Yuan, Hongbin; Barile, Elisa; Emdadi, Aras; Murphy, Ria; Pellecchia, Maurizio. Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorg. Med. Chem. (2009), 17(7), 2712-2717.

Surya K. De, John L. Stebbins, Li-Hsing Chen, Megan Riel-Mehan, Thomas Machleidt, Russell Dahl, Hongbin Yuan, Aras Emdadi, Elisa Barile, Vida Chen, Ria Murphy and Maurizio Pellecchia. Design, Synthesis, and Structure-Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole inhibitors of the c-Jun N-Terminal Kinase. J Med Chem. (2009) 52(7):1943-52.

Muhammad Alimuddin, Daniel Grant, Daryl Bulloch, Martin Peacock, Russell Dahl. Determination of Log D via Automated Microfluidic Liquid-liquid Extraction. J. Med. Chem. (2008) 51(16), 5140-5142.

Jui-Wen Huang, Ziming Zhang, Bainan Wu, Jason F. Cellitti, Xiyun Zhang, Russell Dahl, Chung-Wai Shiau, Kate Welsh, Aras Emdadi, John L. Stebbins, John C. Reed and Maurizio Pellecchia. Fragment-Based Design of Small Molecule XIAP Inhibitors. J. Med. Chem. (2008), 51 (22), 7111–7118.

Dongzhu Jin, David D. Thomas, Razvan Cornea, Yifan Zhai, Russell Dahl, Thomas Larocca, Krisztina Zsebo, Roger J. Hajjar, Fadi G. Akar. A Novel Small Molecule Approach for Treating Mechano-electrical Dysfunction in Heart Failure. American Heart Association Scientific Sessions, Orlando, Florida (2009).

Roberta Noberini, Mitchell Koolpe, Satyamahesh Peddibhotla, Russell Dahl, Ying Su, Nicholas Cosford, Gregory P. Roth, and Elena B. Pasquale. Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors. J. Biol. Chem. (2008), 283(43):29461-72.

Grant, Daniel; Dahl, Russell; Cosford, Nicholas. Rapid Multi-Step Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence. J Org Chem. (2008) 73(18), 7219-7223.

Antonio Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Andrew Gibbs, Jeff Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Ed Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, Christopher J. Larson. “Reverse” α-ketoamide based p38 MAP kinase inhibitors. Bioorg Med Chem Lett. (2008), 18(20), 5456-9.

Antonio Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Justin T. Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Edward Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, Christopher J. Larson. The design and synthesis of novel α-ketoamide based p38 MAP kinase inhibitors. Bioorg Med Chem Lett. (2008) 18, 1772.

Ernst, Justin, Dahl, Russell, Lum, Chris, Sebo, Lubo, Urban, Jan, Miller, Steve, Lundström, Jan. Anti-HIV-1 entry optimization of novel imidazopiperidine-tropane CCR5 antagonists. Bioorg Med Chem Lett. (2008) 18, 1498.

Elizabeth Crawford, Russell Dahl, Doug Duquette, Daniel Grant, Richard Gray, Brian D. Musscleman, Martin J. Peacock, James Petersen. Microfluidic Enabled Biodiesel Production via Liquid-Liquid Extraction and Online MS Analysis. Preprints of Symposia - American Chemical Society, Division of Fuel Chemistry (2008), 53(2), 571-572.

Sabiha Abbas, Anindita Bhoumik, Russell Dahl, Stefan Vasile, Stan Krajewski, Nicholas D. P. Cosford, Ze’ev A. Ronai. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin. Cancer Res. (2007) 13, 6769.

Paul A. Johnston, Jennifer Phillips, Tong Ying Shun, Sunita Shinde, John S. Lazo, Donna M. Huryn, Michael M. Myers, Boris I. Ratnikov, Jeffrey W. Smith, Ying Su, Russell Dahl, Nicholas D. P. Cosford, Sergey A. Shiryaev, Alex Y. Strongin. High throughput screening (HTS) identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus. Assay Drug Dev Technol. (2007) 6, 737.

Dahl, Russell S. and Finney, Nathaniel S. A Surprising Dipolar Cycloaddition Provides Ready Access to Aminoglycosides. J. Am Chem. Soc. (2004), 126, 8356.

Long, Daniel D.; Dahl, Russell; Jolivet, Catherine; Marshall, Will J.; Termin, Andreas P. Stereo- and regiospecific formation of a highly functionalized bridgehead tricyclic sultam. Tetrahedron Letters (2002), 43(24), 4407-4409.

Jolivet, Catherine; Long, Daniel D.; Dahl, Russell S.; Termin, Andreas P. Structural elucidation and complete assignment of a novel class of sulfonamides: bridgehead tricyclic sultams. Magnetic Resonance in Chemistry (2002), 40(4), 307-310.

Dahl, Russell S.; Finney, Nathaniel S. Simple Glucal-Based Linker for the Immobilization of Alcohols on Solid Support. Journal of Combinatorial Chemistry (2001), 3(4), 329-331.

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