Marc J. Glucksman, Ph.D.

Professor & Chair, Biochemistry
and Molecular Biology
Director, Midwest Proteome Center

Chicago Medical School
Biochemistry and Molecular Biology
Room: 3.162/3.176
Building: BSB
Phone: 847.578.3235
Fax: 847.578.3240
Marc.Glucksman@rosalindfranklin.edu 
Publications

SELECTED PUBLICATIONS:
(to download a PDF file of the publication, click on the reference)

Russo LC, Goñi CN, Castro LM, Asega AF, Camargo AC, Trujillo CA, Ulrich H, Glucksman MJ, Scavone C, Ferro ES.  Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation. FEBS J. 276(16):4358-71 [2009]. medline

Boudreau AC, Ferrario CR, Glucksman MJ, Wolf ME. Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine. J Neurochem. 110(1):363-77 [2009]. medline

Tuysuz B, Mosig R, Altun G, Sancak S, Glucksman MJ, Martignetti JA.  A novel matrix metalloproteinase 2 (MMP2) terminal hemopexin domain mutation in a family with multicentric osteolysis with nodulosis and arthritis with cardiac defects. Eur J Hum Genet. 17(5):565-72 [2009]. medline

Bruce LA, Sigman JA, Randall D, Rodriguez S, Song MM, Dai Y, Elmore DE, Pabon A, Glucksman MJ, Wolfson AJ. Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection. FEBS J. 275(22):5607-17 [2008]. medline

Huang JY, Bruno AM, Patel CA, Huynh AM, Philibert KD, Glucksman MJ, Marr RA. Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.  Neuroscience. 155(1):258-62 [2008]. medline

Lindvall LE, Kormeili T, Chen E, Ramirez MC, Grum-Tokars V, Glucksman MJ, Martignetti JA, Zaragoza MV, Dyson SW. Infantile systemic hyalinosis: Case report and review of the literature. J Am Acad Dermatol. 58(2):303-7 [2008]. medline

Roberts JL, Mani SK, Woller MJ, Glucksman MJ, Wu TJ. LHRH-(1-5): a bioactive peptide regulating reproduction. Trends Endocrinol Metab. 18(10):386-92 [2007]. medline

Scholle MD, Kriplani U, Pabon A, Sishtla K, Glucksman MJ, Kay BK  Mapping protease substrates using a biotinylated phage substrate library.  Chem.Bio.Chem.7(5):834-8. [2006] medline

Wu TJ, Glucksman MJ, Roberts JL, Mani SK. Facilitation of Lordosis in Rats by a Metabolite of Luteinizing Hormone Releasing Hormone (LHRH). Endocrinology 147:2544-2549 [2006] medline

Jeske NA, Berg KA, Cousins JC, Ferro ES, Clarke WP, Glucksman MJ, Roberts JL. Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia. J Neurochem. 97, 13-21 [2006] medline

Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 280:41595-608 [2005] medline

Oliveira V, Garrido PA, Rodrigues CC, Colquhoun A, Castro LM, Almeida PC, Shida CS, Juliano MA, Juliano L, Camargo AC, Hyslop S, Roberts JL, Grum-Tokars V, Glucksman MJ, Ferro ES. Calcium modulates endopeptidase 24.15 membrane association, secondary structure and substrate specificity. FEBS J. 272:2978-92 [2005] medline

Sigman JA, Patwa TH, Tablante AV, Joseph CD, Glucksman MJ, Wolfson AJ. Flexibility in substrate recog-nition by thimet oligopeptidase as revealed by denaturation studies. Biochem J. 388, 255-61. [2005] medline

Wu TJ, Mani SK, Glucksman MJ, Roberts JL. Stimulatory Effect of Luteinizing Hormone-Releasing Hormone (LHRH) Metabolite, LHRH(1-5), on LHRH Gene Expression in GT1-7 Cells. Endocrinology 146, 280-6. [2005] medline

Swanson TA, Kim SI, Myers M, Pabon A, Philibert KD, Wang M, Glucksman MJ. The role of neuropeptide processing enzymes in endocrine (prostate) cancer: EC 3.4.24.15 (EP24.15) Prot Pept Lett 11, 471-78 [2004] medline

Jeske NA, Glucksman MJ, Roberts,JL.  Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells. J Neurochem. 90, 819-28 [2004] medline

Kim SI, Voshol H, van Oostrum J, Hastings TG, Cascio M, Glucksman MJ.  Neuroproteomics- Expression Profiling of the Brain’s Proteomes in Health and Disease Neurochem Res 29, 1317-31 [2004] medline

Cotter EJ, Sweeney NO, Coen PM, Birney YA, Glucksman MJ, Cahill PA, Cummins PM.  Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling. Arterioscler Thromb Vasc Biol. 24, 457-63 [2004] medline

Jeske N, Glucksman MJ, Roberts J EP24.15 is Associated with Lipid Rafts J. Neurosci Res. 74, 468-73 [2003] medline

Kim SI, Grum-Tokars V, Swanson TA, Cotter EJ, Cahill PA, Roberts JL, Cummins PM Glucksman MJ Novel Roles of Neuropeptide Processing Enzymes: EC3.4.24.15 in the Neurome. J. Neurosci Res. 74, 456-67 [2003] medline

Voshol H, Glucksman MJ, van Oostrum J. Proteomics in the discovery of new therapeutic targets for psychiatric disease. Curr Mol Med. 2003 Aug;3(5):447-58. medline

Dowling O, Difeo A, Ramirez MC, Tukel T, Narla G, Bonafe L, Kayserili H, Yuksel-Apak M, Paller AS, Norton K, Teebi AS, Grum-Tokars V, Martin GS, Davis GE, Glucksman MJ, Martignetti JA. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003 Oct;73(4):957-66. medline

Sigman JA, Sharky ML, Walsh ST, Pabon A, Glucksman MJ, Wolfson AJ. Involvement of surface cysteines in activity and multimer formation of thimet oligopeptidase. Protein Eng. 2003 Aug;16(8):623-8. medline

Kim SI, Pabon A, Swanson TA, Glucksman MJ. Regulation of cell-surface major histocompatibility complex class I expression by the endopeptidase EC3.4.24.15 (thimet oligopeptidase). Biochem J. 2003 Oct 1;375(Pt 1):111-20. medline

Sigman JA, Edwards SR, Pabon A, Glucksman MJ, Wolfson AJ. pH dependence studies provide insight into the structure and mechanism of thimet oligopeptidase (EC 3.4.24.15). FEBS Lett. 2003 Jun 19;545(2-3):224-8. medline

Narla G, Heath KE , Reeves HL, Li D, Giono LE , Kimmelman AC, Glucksman MJ, Narla J, Eng F, Chan AM, Ferrari A, Martignetti JA, Friedman SL KLF6, a candidate tumor suppressor gene mutated in prostate cancer. SCIENCE 2001 Dec 21; 294: 2563-2566.  medline

Heath KE, Campos-Barros A, Toren A, Rozenfeld-Granot G, Carlsson LE, Savige J, Denison JC, Gregory MC, White JG, Barker DF, Greinacher A, Epstein CJ, Glucksman MJ, Martignetti JA. Nonmuscle myosin heavy chain iia mutations define a spectrum of autosomal dominant macrothrombocytopenias: may-hegglin anomaly and fechtner, sebastian, epstein, and alport-like syndromes. Am J Hum Genet. 2001 Nov;69(5):1033-45. medline

Terasawa E, Busser BW, Luchansky LL, Sherwood NM, Jennes L, Millar RP, Glucksman MJ, Roberts JL.  Presence of luteinizing hormone-releasing hormone fragments in the rhesus monkey forebrain.  J Comp Neurol. 2001 Oct 29;439(4):491-504. medline

Martignetti JA, Aqeel AA, Sewairi WA, Boumah CE, Kambouris M, Mayouf SA, Sheth KV, Eid WA, Dowling O, Harris J, Glucksman MJ, Bahabri S, Meyer BF, Desnick RJ.  Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Nat Genet. 2001 Jul;28(3):261-5. medline

Tullai J, Cummins PM, Pabon A, Roberts J, Lopingco M, Shrimpton CN, Smith AI, Martignetti J, Ferro ES, Glucksman MJ. The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation. J Biol Chem 2000 Nov 24;275(47):36514-22. medline

Heath,KE Babcock,M Glucksman,MJ Aliprandis,E Bizzaro,N Desnick,RJ Martignetti,JA & The May Hegglin/ Fechtner Syndrome Consortium group.  Mutations in the nonmuscle myosin heavy chain IIA gene (MYH9) result in the diverse phenotypes of the May-Hegglin anomaly, Fechtner and Sebastian syndromes. Nat Genet. 2000 Sep;26(1):103-5.  medline

Ferro ES, Tullai J, Glucksman MJ, Roberts J. Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15). DNA Cell Biol 1999 Oct;18(10):781-9. medline

Massarelli,EE Casatti,CA Kato,A Camargo,ACM Bauer,JA Glucksman,MJ Roberts,JL Hirose,S & Ferro,ES Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain. Brain Res. 851, 261 [1999] medline

Cummins PM, Pabon A, Margulies EH, Glucksman MJ. Zinc coordination and substrate catalysis within the neuropeptide processing enzyme endopeptidase EC 3.4.24.15. Identification of active site histidine and glutamate residues. J Biol Chem 1999 Jun 4;274(23):16003-9. medline

Crack PJ, Wu T, Cummins PM, Ferro ES, Tullai J, Glucksman MJ, Roberts J. The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane. Brain Res 1999 Jul 24;835(2):113-24. medline

Wu T, Pierotti AR, Jakubowski M, Sheward WJ, Glucksman MJ, Smith AI, King JC, Fink G, Roberts J. Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge. J Neuroendocrinol 1997 Nov;9(11):813-22. medline

Shrimpton CN, Glucksman MJ, Lew RA, Tullai J, Margulies EH, Roberts J, Smith AI. Thiol activation of endopeptidase EC 3.4.24.15. A novel mechanism for the regulation of catalytic activity. J Biol Chem 1997 Jul 11;272(28):17395-9. medline

Meckelein B, de Silva HA, Roses AD, Rao PN, Pettenati MJ, Xu PT, Hodge R, Glucksman MJ, Abraham CR. Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus. Genomics 1996 Jan 15;31(2):246-9. medline

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