Michela (Micky) Marinelli, Ph.D.

Associate Professor
Ph.D., 1997, University of Bordeaux 2 (France)

Office: 2.124
Building: BSB
Phone: 847-578-8673
Fax: 847-578-3268
Email: micky.marinelli@rosalindfranklin.edu

Publications

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McCutcheon JE, Conrad KL, Carr SB, Ford KA, McGehee DS, Marinelli M (2012) Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults.  J Neurophysiol Jun 20. [Epub ahead of print]. Abstract

McCutcheon JE, Loweth JA, Ford KA, Marinelli M, Wolf ME, Tseng KY. (2011) Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism.  J Neurosci 31:14536-41. Abstract

McCutcheon JE, Wang X, Tseng KY, Wolf ME, Marinelli M (2011) Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci 31:5737-5743. Abstract

Conrad KL, Ford KE, Marinelli M, Wolf ME (2010) Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration. Neuroscience 169:182-194. Abstract

Van Waes V, Beverley J, Marinelli M, Steiner H (2010) SSRI antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum Eur J Neurosci 32:435-447. Abstract

Conrad KL, McCutcheon JE, Cotterly LM, Ford KA, Beales M, Marinelli M (2010) Persistent increases in cocaine-seeking behavior after acute exposure to cold swim stress. Biol Psych 68:303-305. Abstract

Steiner H, Van Waes V, Marinelli M (2010) Fluoxetine potentiates methylphenidate-induced gene regulation in addiction-related brain regions: Concerns for use of cognitive enhancers? Biol Psych, 67:592-594 Abstract

Zahm DS, Becker ML, Freiman AJ, Strauch S, Geisler S, Meredith GE, Marinelli M (2010) Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the basal forebrain and recalibration of expression. Neuropsychopharmacology, 35:445-594. Abstract

McCutcheon, White FJ, Marinelli M (2009) Individual differences in dopamine cell neuroadaptations following cocaine self-administration. Biol Psych, 66:801-803. Abstract

McCutcheon JE, Marinelli M (2009) Age matters. Eur J Neurosci  29:997-1014. Abstract

Jhou TC, Geisler S, Marinelli M, DeGarmo BA, Zahm DS (2009) The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta. J Comp Neurol  513:566–596. Abstract

Ambroggi F, Turiault M, Milet A, Deroche-Gamonet V, Parnaudeau S, Balado E, Barik J, van der Veen R, Maroteaux G, Lemberger T, Schütz G, Lazar M, Marinelli M, Piazza PV, Tronche F (2009) Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nature Neurosci 12:247-249. Abstract

Geisler S, Marinelli M, DeGarmo B, Becker ML, Freiman AJ, Beales M,. Meredith GE, Zahm DS (2008) Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. Neuropsychopharmacology 33:2688-2670. Abstract

Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng L-J, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121. Abstract

Marinelli M (2007) Dopaminergic reward pathways and effects of stress. In: Stress and Addiction: Biological and Psychological Mechanisms. Ed: Mustafa al’Absi. Elsevier Science, pp. 41-83. Abstract

Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ (2006) Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51:801-810. Abstract  PDF

Cagniard B, Beeler J, Britt J, McGehee D, Marinelli M, Zhuang X (2006) Dopamine scales performance in the control of voluntary behavior. Neuron 51:541-547 Abstract  PDF

Marinelli M, Rudick CN, Hu X-T, White FJ (2006) Excitability of dopamine neurons: modulation and physiological consequences CNS Neurol Disord Drug Targets 5:79-97 (Review) Abstract

Marinelli M (2005) The many facets of the locomotor response to a novel environment test: theoretical comment on Mitchell, Cunningham, and Mark (2005). Behav Neurosci 119:1144-1151 Abstract  PDF

Mathon DS, Ramakers GM, Pintar JE, Marinelli M (2005) Decreased firing frequency of midbrain dopamine neurons in mice lacking mu opioid receptors. Eur J Neurosci 21:2883-2886   PDF

Brandon CL, Marinelli M, White FJ (2003) Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biol Psychiatry 54:1338-1344 Abstract  PDF

Marinelli M, Cooper DC, Baker LK, White FJ (2003) Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior. Psychopharmacology 168:84-98 Abstract  PDF

Shalev U, Marinelli M, Baumann MH, Piazza PV, Shaham Y (2003) The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat. Psychopharmacology 168:170-176 Abstract  PDFMarinelli M, Piazza PV (2002) Interaction between glucocorticoid hormones, stress and psychostimulant drugs.  Eur J Neurosci 16:387-394 (Review) Abstract  PDF

Lu W, Marinelli M, Xu D, Worley PF, Wolf ME (2002) Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area, nucleus accumbens or prefrontal cortex, but Narp may contribute to individual differences in responding to a novel environment.  Eur J Neurosci 15:2027-2036 Abstract  PDF

Brandon CL, Marinelli M, Baker LK, White FJ (2001) Enhanced Reactivity and Vulnerability to Cocaine Following Methylphenidate Treatment in Adolescent Rats.  Neuropsychopharmacology 25:651-661 Abstract  PDF

Marinelli M, Cooper DC, White FJ (2001) Electrophysiological correlates of enhanced vulnerability to cocaine self-administration. In: Phenotypic differences in drug effects related to behavioral traits versus states. N.I.D.A. Res Monogr Rev 181:46-48 PDF

Marinelli M, White FJ (2000) Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J Neurosci 20:8876-8885 Abstract  PDF

Barrot M, Marinelli M, Abrous DN, Rouge-Pont F, Le Moal M, Piazza PV (2000) The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent.  Eur J Neurosci. 12:973-979 Abstract  PDF

Barrot M, Marinelli M, Abrous DN, Rougé-Pont F, Le Moal M, Piazza PV (1999) Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex. Eur J Neurosci 11:1155-66 Abstract  PDF

Marinelli M, Aouizerate B, Barrot M, Le Moal M, Piazza PV (1998) Dopamine-dependent responses to morphine depend on glucorticoid receptors. Proc Natl Acad Sci USA 95: 7742-7747 Abstract  PDF

Marinelli M, Le Moal M, Piazza PV (1998) Sensitization to the motor effects of contingent infusions of heroin but not of k agonist RU 51599. Psychopharmacology 139:281-285 Abstract  PDF

Marinelli M, Barrot M, Simon H, Oberlander C, Dekeyne A, Le Moal M, Piazza PV (1998) Pharmacological stimuli decreasing nucleus accumbens dopamine can act as positive reinforcers but have a low addictive potential. Eur J Neurosci 10:3269-3275 Abstract  PDF

Marinelli M, Rougé-Pont F, Deroche V, Barrot M, De Jésus Oliveira C, Le Moal M, Piazza PV (1997) Glucocorticoids & behavioral effects of psychostimulants I: Locomotor response to cocaine depends on basal levels of glucocorticoids. J Pharm Exp Ther 281:1392-1400 Abstract  PDF

Deroche V, Marinelli M, Le Moal M, Piazza PV (1997) Glucocorticoids & behavioral effects of psychostimulants II: Cocaine intravenous self-administration and reinstatement depend on glucocorticoids levels. J Pharm Exp Ther 281:1401-1407 Abstract  PDF

Marinelli M, Rougé-Pont F, De Jésus Oliveira C, Le Moal M, Piazza PV (1997) Acute blockade of corticosterone secretion decreases the psychomotor stimulant effects of cocaine. Neuropsychopharmacology 16:156-161 Abstract  PDF

Marinelli M, Le Moal M, Piazza PV (1996) Acute pharmacological blockade of corticosterone secretion reverses food restriction-induced sensitization of the locomotor response to cocaine. Brain Res 724:251-255 Abstract  PDF

Deroche V, Marinelli M, Maccari S, Le Moal M, Simon H, Piazza PV (1995) Stress-induced sensitization and glucocorticoids. I Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion. J Neurosci 15:7181-7188 Abstract  PDF

Rougé-Pont F, Marinelli M, Le Moal M, Simon H, Piazza PV (1995) Stress-induced sensitization and glucocorticoids. II Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion. J Neurosci 15:7189-7195 Abstract  PDF

Piazza PV, Marinelli M, Jodogne C, Deroche V, Rougé-Pont F, Maccari S, Le Moal M, Simon H (1994) Inhibition of corticosterone synthesis by metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration. Brain Res 658:259-264. Abstract

Marinelli M, Piazza PV, Deroche V, Maccari S, Le Moal M, Simon H (1994) Corticosterone circadian secretion differentially facilitates dopamine-mediated psychomotor effect of cocaine and morphine. J Neurosci 14:2724-2731 Abstract  PDF 

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