Henry Sackin, Ph.D.

Professor and Vice Chair, Physiology and Biophysics

Chicago Medical School
Building: BSB-3.274
Phone: 847-578-8329
Fax: 847-578-3265
henry.sackin@rosalindfranklin.edu
Publications

Recent Publications

Sackin, H., Nanazashvili, M., Li, H., Palmer, L. G., Yang, L. (2012). Residues at the outer mouth of Kir1.1 determine K-dependent gating. Biophysical Journal. 102: 2742-2750

Yang, L., Edvinsson, J., Sackin, H., and Palmer, L. G.. (2012). Ion selectivity and current saturation in inward rectifier K channels. J. Gen. Physiol. 139: 145-157


Sackin, H., Nanazashvili, M., Li, H., Palmer, L.G. and L. Yang. (2011). Modulation of Kir1.1 inactivation by extracellular Ca and Mg. Biophysical Journal. 100:1207-1215.

Sackin H, Nanazashvili, M., Li,H., Palmer L.G. and D.E. Walters. (2010). A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity. Channels. 4: 203-214.

Sackin H, Nanazashvili, M., Li,H., Palmer L.G. and D.E. Walters. (2009). An inter-subunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1. Biophysical Journal. 97: 1058-1066.

Sackin H, et al. (2007). External K Activation of Kir1.1 depends on the pH Gate. Biophysical Journal Vol 93: L14-L16.

Nanazashvili, M., Li,H., Palmer L.G., Walters D.E., and Sackin H. (2007). Moving the pH gate of the Kir1.1 inward rectifier channel. Channels Vol 1: 21 - 28

Zhang, Y., Sackin, H., and L.G. Palmer (2006). Localization of the pH gate in Kir1.1 channels. Biophysical Journal 91:2901-2909.

Sackin, H., Nanazashvili, M., Palmer, L.G., and Hui Li (2006). Role of conserved glycines in pH gating of Kir1.1 (ROMK). Biophysical Journal 90:3582-3589.
 
Sackin H, Nanazashvili, M., Palmer L.G., Krambis, M. and D.E. Walters. (2005). Structural locus of the pH gate in the Kir1.1 inward rectifier channel. Biophysical Journal. 88: 2597-2606.

Sackin H, L.G. Palmer, and M. Krambis. (2004). Potassium-dependent slow inactivation of Kir1.1 (ROMK) channels. Biophysical Journal. 86: 2145-2155.

Dahlmann A, Li M, Gao ZH, McGarrigle D, Sackin H, and L. G. Palmer. (2004). Regulation of Kir channels by intracellular pH and extracellular K+: Mechanisms of Coupling J. Gen. Physiol. 123: 441- 454.

Sackin H, Vasilyev S., Palmer, L.G. and M. Krambis. (2003). Permeant cations and blockers modulate pH gating of ROMK channels. Biophysical Journal. 84: 910-921.

Sackin H, et al. (2007). External K Activation of Kir1.1 depends on the pH Gate. Biophysical Journal Vol 93: L14-L16.

Choe, H., Sackin H, and Palmer, L.G. (2001). Gating Properties of Inward-Rectifier Potassium Channels: Effects of Permeant Ions. J. Memb Biol 184: 81-89.

Choe, H., Sackin H, and Palmer, L.G. (2000). Permeation Properties of Inward-Rectifier Potassium Channels and Their Molecular Determinants J. Gen. Physiol. 115: 391-404.

Choe, H., Palmer, L.G. and Sackin H. (1999). Structural determinants of gating in inward rectifier K channels. Biophysical Journal. 76: 1988-2003.

Frindt, G., Zhou, H., Sackin H. and Palmer, L.G. (1998). Dissociation of K channel density and ROMK mRNA in the rat cortical collecting tubule during K adaptation. Am. J. Physiol. 274(Renal) : F525-F531.

Choe, H., Sackin H, and Palmer, L.G. (1998). Permeation and Gating of an Inwardly Rectifying Potassium Channel: Evidence for a variable energy well.. J. Gen. Physiol. 112: 433 - 446.

Choe, H., Zhou, H., Palmer, L.G. and Sackin H.(1997). A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating. Am. J. Physiol. 273 (Renal) : F516-F529.

 

 

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