D. Eric Walters, PhD

Associate Dean, Research
Professor, Pharmaceutical Sciences
College of Pharmacy
Building: IPEC
Room: 2.608
Phone: 847-578-8613
Email: Eric.Walters@rosalindfranklin.edu
Recent Publications

Binding of Glutamate to the Umami Receptor.  J.J. López Cascales, S.D. Oliveira Costa, B.L. de Groot, and D.E. Walters.  Biophys. Chem., 152:139-144, 2010.  PMID: 20961679

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3:BH3 contact interface in BAK homooligomers.  K.J. Oh, P. Singh, K. Lee, K. Foss, S. Lee, M. Park, S. Lee, S. Aluvila, M. Park, P. Singh, R.-S. Kim, J. Symersky, and D.E. Walters.   J. Biol. Chem., 285:28924-28937, 2010.  PMCID: PMC2937919

The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity.  S. Aluvila, R. Kotaria, J. Sun, J.A. Mayor, D.E. Walters, D.H.T. Harrison, and R.S. Kaplan.   J. Biol. Chem., 285:27314-27326, 2010.  PMCID: PMC2930730

Mitochondrial and plasma membrane citrate transporters: discovery of selective inhibitors and application to structure/function analysis.  J. Sun, S. Aluvila, R. Kotaria, J.A. Mayor, D.E. Walters, and R.S. Kaplan.  Molec. Cell. Pharmacol., 2:101-110, 2010.  PMCID: PMC2913483

A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.  H. Sackin, M. Nanazashvili, H. Li, L.G. Palmer, and D.E. Walters.  Channels, 4:203-214, 2010.

Probing the Effect of Transport Inhibitors on the Conformation of the Mitochondrial Citrate Transport Protein via a Site-Directed Spin Labeling Approach.  J.A. Mayor, J. Sun, R. Kotaria, D.E. Walters, K.-J. Oh, and R.S. Kaplan.   J. Bioenerg. Biomembr., 42:99-109.  2010.  PMCID: PMC2867622

Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.  A.K. Ghosh, S. Gemma, E. Simoni, A. Baldridge, D.E. Walters, K. Ide, Y. Tojo, Y. Koh, M. Amano, and H. Mitsuya.  Bioorg. Med. Chem. Lett., 20, 1241-1246.  2010.

Ion Selectivity of α-Hemolysin with β-Cyclodextrin Adapter: II. Multi-Ion Effects Studied with Grand Canonical Monte Carlo/Brownian Dynamics Simulations.  B. Egwolf, Y. Luo, D.E. Walters, and B. Roux.  J. Phys. Chem. B, 114, 2901-2909. 2010.  PMCID: PMC2843906

Ion Selectivity of α-Hemolysin with β-Cyclodextrin Adapter: I. Single Ion Potential of Mean Force and Diffusion Coefficient.  Y. Luo, B. Egwolf, D.E. Walters, and B. Roux.  J. Phys. Chem. B, 114, 952-958. 2010.  PMCID: PMC2847479

Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor.  S. Aluvila, J. Sun, D.H.T. Harrison, D.E. Walters, and R.S. Kaplan.  Mol. Pharmacol.  77, 26-34.  2010.  PMCID: PMC2802432

Design and evaluation of new analogs of the sweet protein brazzein.  D.E. Walters, T. Cragin, Z. Jin, J.N. Rumbley, and G. Hellekant.  Chem. Senses  34, 679-683. 2009.  PMCID: PMC2745351

An inter-subunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1.  H. Sackin, M. Nanazashvili, H. Li, L.G. Palmer, and D.E. Walters.  Biophys. J.  97, 1058 - 1066, 2009.  PMCID: PMC2726312

Molecular dynamics study of a polymeric reverse osmosis membrane.  E. Harder, D.E. Walters, Y.D. Bodnar, R.S. Faibish, and B. Roux.  J. Phys. Chem. B  113, 10177-10182, 2009.  PMCID: PMC2847479

The yeast mitochondrial citrate transport protein:  identification of the lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate.  S. Remani, J. Sun, R. Kotaria, J.A. Mayor, J.M. Brownlee, D.H.T. Harrison, D.E. Walters, and R.S. Kaplan.  J. Bioenerg. Biomembr. 40, 577-585, 2008.  PMCID: PMC2775541

Introduction of The Chloroplast Redox Regulatory Region In the Yeast ATP Synthase Impairs Cytochrome c Oxidase.  H. Shen, D.E. Walters, and D.M. Mueller.   J. Biol. Chem. 283, 32937-32943, 2008.  PMCID: PMC2583308

Computational docking to sweet taste receptor models.   D.E. Walters.  In Sweetness and Sweeteners:  Biology, Chemistry and Psychophysics, D.K. Weerasinghe and G.E. DuBois, Eds., Oxford University Press, 2007.

External K activation of Kir1.1 depends on the pH gate.  H. Sackin, M. Nanazashvili, H. Li, L.G. Palmer, and D.E. Walters.  Biophys. J. 93, L14-L16, 2007.  PMCID: PMC1896244

Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein.  C. Ma, S. Remani, J. Sun, R. Kotaria, J.A. Mayor, D.E. Walters, and R.S. Kaplan.  J. Biol. Chem. 282, 17210-17220, 2007.

Moving the pH gate of the Kir1.1 inward rectifier channel.  M. Nanazashvili, H. Li, L.G. Palmer, D.E. Walters, and H. Sackin.  Channels 1, e1-e8, 2007

Presence of the anti-leukemic nucleotide analog, 2-chloro-2′-deoxyadenosine-5′-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP).  W.R. Hartman, D.E. Walters, and P. Hentosh.  Arch. Biochem. Biophys. 459, 223-232, 2007.

Interactions of the sweet protein brazzein with the sweet taste receptor.  D.E. Walters and G. Hellekant.  J. Agric. Food Chem. 54, 10129-10133, 2006.  PMCID: PMC2527743

The mitochondrial citrate transport protein:  Evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues.  C. Ma, S. Remani, R. Kotaria, J.A. Mayor, D.E. Walters, and R.S. Kaplan.  Biochim. Biophys. Acta  1757, 1271-1276, 2006.

Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance.  A.K. Ghosh, P.R. Sridhar, S. Leshchenko, A.K. Hussain, J. Li, A.Yu.Kovalevsky, D.E. Walters, J.E. Wedekind, V. Grum-Tokars, D. Das, Y. Koh, K. Maeda, H. Gatanaga, I.T. Weber, and H. Mitsuya. J. Med. Chem. 49, 5252-5261, 2006.

Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.  A.K. Ghosh, G. Schiltz, R.S. Perali, S. Leshchenko, S. Kay, D.E. Walters, Y. Koh, K. Maeda, and H. Mitsuya.  Bioorg. Med. Chem. Lett.  16, 1869-1873, 2006.

Improving the taste of sweeteners.  D.E. Walters.  In Optimizing Sweet Taste in Foods, W.J. Spillane, Ed., Woodhead Publishing, Cambridge, 2006,  pp. 344-348.

Analyzing and predicting properties of sweet-tasting compounds.  D.E. Walters.  In Optimizing Sweet Taste in Foods, W.J. Spillane, Ed., Woodhead Publishing, Cambridge, 2006,  pp. 283-291.

Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.  A.K. Ghosh, L.M. Swanson,  H. Cho, S. Leshchenko, K.A. Hussain, S. Kay, D.E. Walters, Y. Koh, and H. Mitsuya,  J. Med. Chem. 48, 3576-3585, 2005.

Structural locus of the pH gate in the Kir1.1 inward rectifier channel.  H. Sackin, M. Nanazashvili, L.G. Palmer, M. Krambis, and D.E. Walters, Biophys. J. 88, 2597-2606, 2005.  PMCID: PMC1305356

The yeast mitochondrial citrate transport protein:  Characterization of transmembrane domain III residue involvement in substrate translocation.  C. Ma, R. Kotaria, J.A. Mayor, S. Remani, D.E. Walters and R.S. Kaplan, J. Biol. Chem. 280, 2331-2340, 2005.

Homology modeled structure of the yeast mitochondrial citrate transport protein.  D.E. Walters and R.S. Kaplan, Biophys. J. 87, 907-911, 2004.  PMCID: PMC1304499

2-Chloro-2'-deoxyadenosine: alteration of DNA:TATA element binding protein (TBP) interactions.  T.T. Foley, P. Hentosh, and D.E. Walters, J. Mol. Model, 10, 32-37, 2004.

The mitochondrial citrate transport protein:  Probing the secondary structure of transmembrane domain III, identification of residues that likely comprise a portion o f the citrate transport pathway, and development of a model for the putative TMDIII-TMDIII' interface.  C. Ma, R. Kotaria, J.A. Mayor, L.R. Eriks, A.M. Dean, D.E. Walters, and R.S. Kaplan, J. Biol. Chem., 279, 1533-1540, 2004.

Homology-based model of the extracellular domain of the taste receptor T1R3.  D.E. Walters, Pure & Appl. Chem., 74, 1117-1123, 2002.

Novel cyclourethane-derived HIV protease inhibitors:  a ring-closing olefin metathesis strategy.  A.K. Ghosh, L.M. Swanson, C. Liu, K.A. Hussain, H. Cho, D.E. Walters, L. Holland, and J. Buthod, Bioorg. Med. Chem. Lett., 12, 1993-1996, 2002.

Structure-based design of non-peptide HIV protease inhibitors.  A.K. Ghosh, D. Shin, L. Swanson, K. Krishnan, H. Cho, K.A. Hussain, D.E. Walters, L. Holland, and J. Buthod, Il Farmaco, 56, 29-32, 2001. 

Regulation of ROMK by Extracellular Cations.  H. Sackin, S. Syn, L. G. Palmer, H. Choe, and D. E. Walters, Biophys. J. 80, 683-697, 2001.

Modifying the Temporal Profile of the High-Potency Sweetener Neotame.  I. Prakash, I. E. Bishay, N. Desai, and D. E. Walters, J. Agric. Food Chem. 49, 786-789, 2001.

Models of the Transmembrane Domains of the Yeast Mitochondrial Citrate Transport Protein.  D.E. Walters and R.S. Kaplan, J. Molecular Modeling, 6, 587-594, 2000.

The Yeast Mitochondrial Citrate Transport Protein:  Determination of Secondary Structure and Solvent Accessibility of Transmembrane Domain IV Using Site-directed Spin Labeling.  R.S. Kaplan, J.A. Mayor, R. Kotaria, D.E. Walters, and H.S. Mchaourab, Biochemistry, 39, 9157-9163, 2000.

The Yeast Mitochondrial Citrate Transport Protein:  Probing the Secondary Structure of Transmembrane Domain IV and Identification of Residues that Likely Comprise a Portion of the Citrate Translocation Pathway.  R.S. Kaplan, J.A. Mayor, D. Brauer, R. Kotaria, D.E. Walters, and A.M. Dean, J. Biol. Chem., 275, 12009-12016, 2000.

The Yeast Mitochondrial Citrate Transport Protein:  Probing the Roles of Cysteines, Arg181 and Arg189 in Transporter Function.  Y. Xu, D.A. Kakhniashvili, D.A. Gremse, D.O. Wood, J.A. Mayor, D.E. Walters, and R.S. Kaplan, J. Biol. Chem., 275, 7117-7124, 2000.

The Active Conformations of Neotame and other High-potency Sweeteners  D.E. Walters, I. Prakash, and N. Desai, J. Med. Chem., 43, 1242-1245, 2000.

Predictive Models of Protein Active Sites.  D.E. Walters, in Protein Structure Prediction:  Methods and Protocols,  D.M. Webster, Ed., Humana Press, Totowa, NJ, 2000, pp. 349-358.

Oligomeric State of Wild-type and Cysteine-less Yeast Mitochondrial Citrate Transport Proteins.  Kotaria, R., Mayor, J.A., Walters, D.E., and Kaplan, R.S.  J. Bioenerg. Biomembr. 6, 543-549, 1999.

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