Arthur S. Schneider, M.D.

Professor of Pathology
Department of Pathology
Chicago Medical School
Room 1.660
Building: HSB
Phone: 847.578-3260
Fax: 847.775-6525
Email Dr. Schneider
Biography
EDUCATION:
M.D., The Chicago Medical School
B.S., University of California, Los Angeles

BOARD CERTIFICATION:
American Board of Pathology: Anatomic Pathology, Clinical Pathology, Hematology
American Board of Internal Medicine

LICENSURE:
California, Colorado, Illinois

PRINCIPAL AREAS OF PROFESSIONAL AND RESEARCH EMPHASIS:

Active teacher and program director, academic department administration, molecular basis of monogenic hematologic disorders.

Recent work has been directed at the molecular genetics of triosephosphate isomerase (TPI) deficiency, a hereditary hemolytic anemia associated with progressive neuromuscular dysfunction. To explain the repetitive occurrence of the 104 mutation in the TPI gene in multiple apparently unrelated families throughout the world, DNA was obtained from all known families with this mutation in order to study the coinheritance of linked polymorphisms. This work has revealed an unusual haplotype, manifest in common in all of the families who carry the 104 mutation, indicating their descent from a common ancestor. Additional recent areas of inquiry include structural analysis of the TPI protein to elucidate the differing mechanisms by which the thirteen known mutations cause impaired enzyme activity and investigations into the nature of the high incidence variants involving the TPI promoter. This set of polymorphisms, which may perhaps be the highest incidence molecular markers of African lineage,are associated with moderate reduction in enzyme activity and in some instances may contribute to compound heterozygosity and clinical TPI deficiency. The finding of subjects homozygous for the -5 -8 haplotype is inconsistent with the putative role (suggested by others) of this haplotype as the cause of a null variant incompatible with life in homozygotes.

SELECTED PUBLICATIONS: Schneider AS, Valentine WN, Hattori M & Heins HL Jr. A new erythrocyte enzyme defect with hemolytic anemia-triosephosphate isomerase (TPI) disease. Blood 1964; 24: 855-856.

Schneider AS, Valentine WN, Hattori M & Heins HL Jr. Hereditary hemolytic anemia with triosephosphate isomerase de®ciency. New England Journal of Medicine 1965; 272: 229-235.

Shore NA, Schneider AS & Valentine WN. Erythrocyte triosephosphate isomerase deficiency. Journal of Pediatrics 1965; 67: 939.

Valentine WN, Schneider AS, Baughan MA et al. Hereditary hemolytic anemia with triosephosphate isomerase deficiency: studies in kindreds with coexistent sickle cell trait and erythrocyte glucose-6- phosphate dehydrogenase deficiency. American Journal of Medicine 1966; 41: 27-41.

Schneider AS, Dunn I, Ibsen KH & Weinstein IM. The pattern of glycolysis in erythrocyte triosephosphate isomerase deficiency. Clinical Research 1965; 13: 282.

Schneider AS, Dunn I, Ibsen KH & Weinstein IM. Triosephosphate isomerase deficiency. B. Inherited triosephosphate isomerase de®ciency. Erythrocyte carbohydrate metabolism and preliminary studies of the erythrocyte enzyme. In Beutler E (ed.) Hereditary Disorders of Erythrocyte Metabolism. City of Hope Symposium Series, Volume 1, pp 273-279. New York: London: Grune & Stratton, 1968.

Dunn I, Schneider AS, Ibsen KH & Weinstein IM. Isoenzymes of triosephosphate isomerase in human erythrocytes. Clinical Research 1967; 15: 104.

Schneider AS. Triosephosphate isomerase deficiency. In Yunis J (ed.) Biochemical Methods in Red Cell Genetics, pp 189-200. New York: Academic Press, 1969.

Schneider AS, Valentine WN, Baughan MA et al. Triosephosphate isomerase deficiency. A. A multi- system inherited enzyme disorder. Clinical and genetic aspects. In Beutler E (ed.) Hereditary Disorders of Erythrocyte Metabolism,. City of Hope Symposium Series, Volume 1, pp 265-272. New York: London: Grune & Stratton, 1968.

Schneider, A.S., Westwood, B., Yim, C., Prchal, J., Berkow, R., Labotka, R., Warrier, R., and Beutler, E.: Triosephosphate isomerase deficiency: Repetitive occurrence of point mutation in amino acid 104 in multiple apparently unrelated families. Am. J. Hematol. 50:263-268, 1995

Schneider, A.S., and Cohen-Solal, M.: Hematologically important mutations: Triosephosphate isomerase. Blood Cells Mol. Dis. 22:82-84, 1996

Schneider, A.S., Westwood, B., Yim, C., Cohen-Solal, M., Rosa, R., Labotka, R., Eber, S., Wolf, R., Lammi, A., and Beutler, E.: The 1591C mutation in triosephosphate isomerase (TPI) deficiency. Tightly linked polymorphisms and a common haplotype in all known families. Blood Cells Mol. Dis. 22:115-125, 1996

Halfman, C., Schneider, A., and Cohen-Solal, M.: Insights from molecular modeling into the mechanisms of impaired catalysis in triosephosphate isomerase (TPI) deficiency. Blood 88 (Suppl. 1): 305a, 1996. (Abstract)

Halfman, C. and Schneider, A.: Hereditary hemolytic anemia with triosephosphate isomerase (TPI) deficiency: Assignment of the known mutation sites to functional molecular domains of the enzyme protein. FASEB J. 11:a532, 1997. (Abstract)

Schneider, A., Forman, L., Westwood, B., Yim, C., Lin, J., Singh, S., and Beutler, E.: The relationship of the -5, -8, and -24 variant alleles in African Americans to triosephosphate isomerase (TPI) enzyme activity and to TPI deficiency. Blood 92:2959-2962, 1998.

Schneider, A.S.: Triosephosphate isomerase deficiency: Historical perspectives and molecular aspects. Baillieres Best Pract Res Clin Haematol13:119-140, 2000.

Valentin,C.; Pissard,S.; Martin,J.; Hron,D.; Labrune,P.; Livet,M.; Mayer,M.; Gelbart,T.; Schneider,A.; Max-Audit,I.; Cohen-Solal,M.: Triose phosphate isomerase deficiency in 3 French families: Two novel null alleles: a frameshift mutation (TPI Alfortville) and an alteration in the initiation codon (TPI Paris). Blood 96: 1130-1135, 2000.

Schneider, A.S., and Szanto, P.A.: Pathology, 1st. ed., Lippincott Williams & Wilkins, Board Review Series, December 1993.

Schneider, A.S., and Szanto, P.A.: Pathology, 2nd. ed., Lippincott Williams & Wilkins, Board Review Series, December 2001.

Schneider, A.S., Szanto, P.A., Kim, S.I., and Swanson, T.A.: Pathology, 3rd. ed., Lippincott Williams & Wilkins, Board Review Series, December 2005.

Schneider, A.S., Szanto, P.A., Kim, S.I., and Swanson, T.A.: Pathology, 4th. ed., Lippincott Williams & Wilkins, Board Review Series, December 2009.

SCIENTIFIC AND PROFESSIONAL SOCIETIES:
Academy of Clinical Laboratory Physicians and Scientists

American Association for the Advancement of Science

American Association of Blood Banks

American Association of University Professors

American College of Physicians

American Federation for Clinical Research

American Society of Clinical Pathologists

American Society of Hematology

American Society of Investigative Pathology

Association for Molecular Pathology

Association of Pathology Chairs

College of American Pathologists

International Academy of Pathology

Society for Hematopathology

Chicago Pathological Society

Illinois Society of Pathologists

Institute of Medicine of Chicago

HONORARY SOCIETIES:
Alpha Omega Alpha

Sigma Xi

HONORS:
Golden Apple Award for Excellence in Teaching, 2001, 2002, 2003, 2004, 2005

Basic Science Professor of the Year, 2005

TEACHING ACTIVITIES:
Director of undergraduate curriculum in pathology.

Teach units on atherosclerosis, glomerular disease, molecular genetics, molecular oncology, and all units on blood disease.

Co-director of graduate programs in pathology and laboratory medicine.

Member of graduate faculty.

COMMITTEES:
Faculty Executive Council

University Research Committee

Basic Science Chairs Committee

Clinical Chairs Committee

Curriculum Committee, years 1 and 2

Association of Pathology Chairs Undergraduate Medical Education Committee
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