Cancer Research
Cancer research at RFUMS involves the use of an array of multidisciplinary approaches to study the:

  • Molecular biology of Kaposi’s sarcoma associated herpes virus  (KSHV) implicated in the etiology of AIDS-related Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, in order to elucidate the mechanism of pathogenesis (Bala Chandran)
  • Epstein-Barr virus (EBV) transforming protein and its role in manipulating cellular signaling pathways involved in tumor formation (Note: EBV is associated with Burkitt’s lymphoma, nasopharyngeal carcinoma, as well as certain types of Hodgkin disease and gastric cancers) (David Everly)
  • Arachidonic acid pathway in KSHV pathogenesis (Neelam Sharma-Walia)
  • Nuclear and mitochondrial cross talk by signal molecules in controlling aerobicglycolysis that is essential for the growth of lymphoma and other cancer cells (Chao-Lan Yu)
  • Glutamate and glutamate receptors that are specifically over expressed in human EBV+ and KSHV+ B-cell lymphoma cells with a goal of utilizing animal models to determine the chemo-therapeutic potential of FDA-approved anti-glutamate and glu-receptor drugs to control and/or eliminate EBV+ and KSHV+ tumor cells (Mohanan Veettil)
  • Hepatitis C viral infection induced inflammation and liver oncogenesis (Gulam Waris).
  • Compartmentalization of the nucleus as it contributes to genome function and regulates genome organization in cancer (Mirek Dundr).