Structural biology projects at RFUMS involve the use of mass spectrometry, x-ray crystallography, electron paramagnetic resonance, plus other biochemical approaches to understand the structure-based mechanism of proteins in both normal and pathologic states.  Projects include the structure and functional mechanism of:

• Potassium channels (Adrian Gross, Henry Sackin)
• The mitochondrial F₁F₀-ATPase (David Mueller)
• The mitochondrial and plasma membrane citrate transporters (Ronald Kaplan)
• Glucose transporters (Jun-yong Choe)
• The Multidrug and Toxin Extrusion transporter (Min Lu)
• Key proteins of apoptosis (Kyoung Joon Oh)
• Essential amino acid transporters in mosquitoes (Dmitri Boudko)
• Enzymes and neuropeptide substrates of several reactions involved in the normal and disease states of neurobiological, aging and reproductive processes (Marc Glucksman).
• Furthermore, proteomic approaches are utilized in projects to identify markers and assess structure-function relationships for diagnostics, risk factors and targets for treatment of Alzheimer's Disease, schizophrenia and endocrine cancers (e.g. prostate) (Marc Glucksman)