Ph.D., University of Michigan, '92 American Cancer Society Fellow Yale University with T.A. Steitz, ’92-‘97 Assistant Professor, University of Chicago,'98-'04
Phone: (847) 578-8611 Fax: (847) 578 3240 Email: Carl.Correll@RosalindFranklin.edu
Interaction between protein and RNA is central to cellular and viral processes ranging from expressing genes to directing cell mortality, yet the principles that govern protein-RNA recognition are poorly understood. RNA can fold and as a consequence can create a great variety of distinctive molecular surfaces. How do these surfaces enable protein-RNA and RNA-RNA recognition? What role do these surfaces play in the structure, function and assembly of ribonucleoprotein (RNP) complexes? Which RNP proteins mediate RNA structural rearrangements and what mechanism do they use? We aim to address these questions by combining crystallographic, energetic and kinetic studies. Current projects focus on deciphering the molecular underpinnings of essential RNA–protein interactions in ribosome biogenesis--a vital cellular process that is emerging as an unexplored target for cancer treatment.
Last updated by Correll November 2, 2010