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Shivaputra A. Patil, PhD

Research Assistant Professor

Shivaputra A. Patil, PhD, Research Assistant Professor of Pharmaceutical Sciences Department, joined the College of Pharmacy in November, 2014. Dr. Patil received his Doctor of Philosophy in Chemistry from the Karnatak University, India in 1998. He worked as Research Associate and Technical Officer at Imperial Chemical Industries India Ltd., New Bombay, India. In 2001, he commenced as National Research Foundation Fellow at university of Witwatersrand, Johannesburg, South Africa. He worked on NIH funded grants at City College of CUNY, New York and University of Tennessee Health Science Center (UTHSC), Memphis, USA. Dr. Patil became Research Assistant professor in 2010 and established drug design and discovery research driven by medicinal chemistry at UTHSC. He is a member of the American Chemical Society (ACS) since 2002. Dr. Patil has published his research in reputed organic, bio-organic and medicinal chemistry journals including book chapter(s). Dr. Patil serves as a reviewer for organic, bioorganic and medicinal chemistry related journals and he continues to serve as an editorial member for Organic Chemistry: Current Research and International Journal of Bioorganic Chemistry & Molecular Biology.

Curriculum Vitae

RESEARCH:

Design and develop small molecules for cancer and viral diseases

The major emphasis of my research is to design and develop novel chemotherapeutic agents for cancer and viral diseases. New chemotherapeutic agents are needed to overcome the resistance in cancer and viral diseases. My medicinal chemistry efforts are focused on the design and synthesis of novel small molecule drug candidates based on the initial hits developed either by the screening process or in our laboratory. My research efforts are at the interface of chemistry and biology and various types of topics within the research area will be studied in detail. Therefore, I look forward to having effective research collaborations with the computational and biological research faculty.

Complete List of Published Work in My Bibliography
https://www.ncbi.nlm.nih.gov/sites/myncbi/shivaputra.patil.1/bibliography/47879709/public/?sort=date&direction=descending

RECENT PUBLICATIONS:

  1. Patil M, Noonikara PA, Joshi SD, Patil SA, Patil SA, Bugarin A New Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies.
    Antibiotics, 2019, 8, 178.
  2. Patil M, Noonikara PA, Joshi SD, Patil SA, Patil SA, Bugarin A. Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agents.
    Bioorganic Chemistry 2019,92,103217.
  3. Kempasiddhaiah M, Kandathil V, Dateer RB, Sasidhar BS, Patil SA, Patil SA. Magnetite tethered mesoionic carbene‐palladium (II): An efficient and reusable nanomagnetic catalyst for Suzuki‐Miyaura and Mizoroki‐Heck cross‐coupling reactions in aqueous medium.
    Applied Organometallic Chemistry, 2019,33(5), e4846.
  4. Patil M, Noonikara PA, Joshi SD, Patil SA, Patil SA, Bugarin A. Synthesis, Molecular Docking Studies, and Antimicrobial Evaluation of New Structurally Diverse Ureas.
    Bioorganic Chemistry (2019), 87, 302.
  5. Patil V, Patil SA, Patil R, Bugarin A, Beaman K, Patil SA*.Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities.
    Med Chem.2019,15(2), 150.

PATENTS AND PATENT APPLICATIONS:

  1. Inventors: Charles Ryan Yates, Duane D. Miller, Frank Park, Jordan J. Toutounchian, Vanessa Moraies-tirado, Shivaputra Patil, Jayaprakash Pagadala, Bial Abou Aleiwi. Inhibitors of paxillin function and related compositions and methods. 2016, Publication number US2016/0347725A1.
  2. Inventors: Siddappa Patil, Shivaputra Patil, Rangappa Keri, Geetha Balakrishna. A novel process for the synthesis of boron enriched magnetic nanoparticles. 2016, Publication number Indian Pat. Appl. (2016), IN 2014CH06012 A 20160826.
  3. Inventors: Siddappa Patil, Shivaputra Patil, Rangappa Keri, Geetha Balakrishna. A novel process for the synthesis of boron enriched magnetic nanoparticles. 2016, Publication number WO2016088137 A2 20160609.
  4. Inventors: Duane D. Miller. Shivaputra A. Patil, Renukadevi Patil, Terreia Jones, Amira Ahmed, Likeselam Asres, Charles Ryan Yates, Eldon Geisert. Compounds with increased specificity for the treatment of glioma. 2015, Patent number: US 9187449.
  5. Inventors: John K. Buolamwini, Shivaputra A. Patil, Horick Sharma, James K. Addo.1-Aryl-or 1-heteroaryl-pyrido[b]indoles and uses thereof in treating cancers. 2012, Patent number: US 8,329,723.
  6. Inventors: Charles R. Yates, Duane D Miller, Frank Park, Jordan J. Toutounchian, Vanessa M. Morales-Tirado, Shivaputra Patil. Pagadala Jayaprakash, Bilal Abou Aleiwi. Inhibitors of paxillin function and related compositions and methods. 2015, Publication number: WO 2015120059 A1 20150813.
  7. Inventors: Duane D. Miller, Shivaputra A. Patil, Renukadevi Patil, Terreia Jones, Amira Ahmed, Likeselam Asres, Charles Ryan Yates, Eldon Geisert. Compounds for the treatment of glioma. 2014, Publication number: WO 2014/160723 A1
  8. Inventors: Duane D. Miller, Shivaputra A. Patil, Renukadevi Patil, Terreia Jones, Amira Ahmed, Likeselam Asres, Charles Ryan Yates, Eldon Geisert. Compounds with increased specificity for the treatment of glioma. 2014, Publication number: US20140296286 A1.
  9. Inventors: Renukadevi Patil, Shivaputra A. Patil, Duane D. Miller, Charles R. Yates, Eldon L. Geisert. 1,2,3,4-Tetrahydroisoquinline derivatives effective as antiglioma agents, methods of making, and their use. 2012, Publication number: US20120059032 A1.
  10. Inventors: John K. Buolamwini, Shivaputra Patil, James K. Addo, Parker D. Suttle, Ruiwen Zhang, Zhengxiang Zhu, Horrik Sharma. 1-Aryl-or 1-heteroaryl-pyrido[b]indoles and uses thereof. 2010,Publication number: US20100317667 A1.

    BOOKS/BOOK CHAPTERS:

    1. Patil R, Powrozek O, Kumar B, Seibel W, Beaman K,Waris G, Sharma-Walia N, Patil S*. Chapter title: “Bisbenzimidazoles: Anticancer Vacuolar (H+)-ATPase Inhibitors”. IntechOpen publishers; Book titled “Chemistry and Applications of Benzimidazole and its Derivatives”Edited by Dr. Maria Marinescu; 2019.
      https://www.intechopen.com/books/chemistry-and-applications-of-benzimidazole-and-its-derivatives/bisbenzimidazoles-anticancer-vacuolar-h-sup-sup-atpase-inhibitors
    2. S. A. Patil*,L. M. Pfeffer , D.D. Miller. ''Gliomas: Classification, symptoms, treatment and prognosis'' Edited by David Adamson, contributed chapter titled Identification of a potent antiglioma agent from pre-clinical screening (Chapter 10; pp. 211-220), Nova Publishers, 2014. https://novapublishers.com/shop/gliomas-classification-symptoms-treatment-and-prognosis/