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Diabetes Research

Diabetes research at RFUMS includes investigations into the:

  • Recruitment of adult endogenous stem cells to overcome impaired wound healing characteristic of the disease (Dan Peterson)
  • Molecular mechanisms underlying diabetic metabolic memory in wound healing and tissue regeneration using an adult Zebrafish model of Type 1 diabetes (Michael Sarras and Robert Intine)
  • Discovery of high-affinity inhibitors and determination of the three-dimensional structure of the INDY (I'm Not Dead Yet) transporter, a carrier which may play a role in obesity, a major risk factor for adult-onset diabetes (Ronald Kaplan and Eric Walters)
  • Determination of the 3-dimensional structure of a glucose transporter facilitating identification of high-affinity inhibitors and activators that may aid in the pharmacologic amelioration of the complications associated with advanced diabetes (Jun-yong Choe)
  • Modulation of reactive oxygen species and calcium signaling pathways in the smooth muscle cells of resistance arterioles in mouse models of diabetes (Carl White)