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Structural Biology Research

Structural biology projects at RFUMS involve the use of mass spectrometry, x-ray crystallography, electron paramagnetic resonance, plus other biochemical approaches to understand the structure-based mechanism of proteins in both normal and pathologic states. Projects include the structure and functional mechanism of:

  • Potassium channels (Adrian Gross, Henry Sackin)
  • The mitochondrial F1F0-ATPase (David Mueller)
  • The mitochondrial and plasma membrane citrate transporters (Ronald Kaplan)
  • Glucose transporters (Jun-yong Choe)
  • The Multidrug and Toxin Extrusion transporter (Min Lu)
  • Key proteins of apoptosis (Kyoung Joon Oh)
  • Essential amino acid transporters in mosquitoes (Dmitri Boudko)
  • Enzymes and neuropeptide substrates of several reactions involved in the normal and disease states of neurobiological, aging and reproductive processes (Marc Glucksman)
  • Furthermore, proteomic approaches are utilized in projects to identify markers and assess structure-function relationships for diagnostics, risk factors and targets for treatment of Alzheimer's disease, schizophrenia and endocrine cancers (e.g. prostate) (Marc Glucksman)