Synthesis Research

Reviews and Protocols

Mining the sheer volume of research available today on any given topic can be overwhelming for healthcare providers trying to keep pace with best practices. The role of synthesis research is to bring together the best evidence on a topic, whether randomized controlled trials or expert opinion on an emerging phenomenon, appraise that evidence, and provide a piece of secondary research that interprets, grades, and synthesizes the information to inform policy or practice. The methodology prescribed by JBI is to first develop a protocol that outlines why the topic deserves to be investigated and how the systematic search will find and review the evidence to draw conclusions. Here are examples of the protocols and full reviews completed and published at our center.

Reviews

• Greenwood J. Crull A, Graves, M, Ledvina M. Effectiveness of intravenous medications in reducing the incidence of myoclonus in patients receiving etomidate for induction of general anesthesia: an umbrella review of systematic reviews. JBI Evidence Synthesis. 2024; 22(1): 66-89. DOI: 10.11124/JBIES-22-00390
•      Dimmen A, Timko S, Greenwood J, McShane F, Uliniski J. Effect of dexamethasone administration for postoperative nausea and vomiting on glucose levels in adult diabetic patients undergoing elective surgery: a systematic review and meta-analysis. JBI Evidence Synthesis. 2023; 21(11): 2156-2187. DOI: 10.11124/JBIES-22-00300
• Greenwood J, Nygard B, Brickey D. Intravenous magnesium sulfate to attenuate hemodynamic changes in laparoscopic surgery: a systematic review of effect. (Accepted for publication in JBI Evidence Synthesis: September 2, 2020). doi: 10.11124/JBISRIR-D-19-00414.
• Larson S, Anderson LR, Thomson JS. The effect of phenylephrine  on cerebral perfusion when used to treat anesthesia-induced hypotension: a systematic review informing nurse anesthesia practice. JBI Evidence Synthesis. 2021; 19(1) 34[JG2] -58. doi: 10.11124/JBISRIR-2017-00352.

Protocols

•      Osuji A, Greenwood J. Effectiveness of autologous or biologic non-surgical interventions for discogenic pain and functional capacity compared to non-surgical and surgical interventions: A systematic review protocol. 2024. Unpublished protocol[JG1] . Registered with PROSPERO: CRD42024560127
•      Smith A, Weigand J, Greenwood J, Tierney K. Safety and effectiveness of regional anesthesia compared to anesthetic techniques not using regional anesthesia on outcomes after free tissue flap surgery: a systematic review protocol. JBI Evidence Synthesis. 2022; 20(10):2591-2598.
•      Dimmen A, Timko S, Greenwood J, Ulinski J, McShane F. Effect of dexamethasone administration for postoperative nausea and vomiting on glucose levels in adult diabetic patients undergoing elective surgery: a systematic review and meta-analysis protocol. 2021 npublished protocol. Registered with PROSPERO: CRD42020185607.
• Greenwood J, Crull A, Graves M. Pharmacological interventions for the reduction in incidence of myoclonus in patients receiving etomidate for induction of general anesthesia: an umbrella review protocol. 2021 Unpublished protocol..
• Ferszt P, Hill J, Larson S. The diagnostic accuracy of ultrasonography relative to Cormack-Lehane in predicting difficult laryngoscopy: a systematic review of diagnostic test accuracy protocol. (Accepted for publication September 3, 2020). doi: 10.11124/JBIES-20-00141.
• Burman T, Idicula J, McShane FJ. Periarticular liposomal bupivacaine versus continuous nerve block in total knee arthroplasty: a systematic review protocol. 2020 [Unpublished protocol].
• Ortiz R, Ede C, Anderson, L. Effectiveness of thoracic epidurals in reducing morbidity and mortality in adults with acute pancreatitis: a systematic review protocol. ( Accepted -in editorial review in JBI Evidence Synthesis: September 2, 2020). doi: 10.11124/JBIES-20-00119.
• Adams JL, Rust DB, Anderson LR, McShane FJ. Safe injection practices among anesthesia providers: a scoping review protocol. JBI Database of Systematic Reviews and Implementation Reports. 2019;17(8):1573-1581. doi:10.11124/jbisrir-2017-003876.
• Fitzgerald H, Anderson E, Anderson LR, Tracy AJ, Thomson JS. Effectiveness of deep general anesthesia compared to the standard depth of general anesthesia for acute postoperative pain and patient safety: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports. 2019;17(10):2129-2135. doi:10.11124/jbisrir-2018-004040.
• Nygard B, Brickey D, Greenwood J. Intravenous magnesium sulfate to attenuate hemodynamic changes in laparoscopic surgery. JBI Database of Systematic Reviews and Implementation Reports. 2019;17(10):2152-2158. doi:10.11124/jbisrir-d-18-00009.
• Schwertfeger JL, Thuente L, Hung P, Larson SL. Post-discharge interventions to enhance coping skills for survivors of stroke and their caregivers. JBI Database of Systematic Reviews and Implementation Reports. 2019:1. doi:10.11124/jbisrir-d-18-00024.

• Russell TW, Rosc AR, McShane FJ. The incidence of post-dural puncture headache in the obese parturient compared to the non-obese parturient after an accidental dural puncture: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports. 2019; 17(0):1-6. doi: 10.11124/JBISRIR-D-19-00037.
• Larson SL, Anderson LR, Thomson JS. The effect of phenylephrine on cerebral perfusion when used to treat anesthesia-induced hypotension. JBI Database of Systematic Reviews and Implementation Reports. 2018;16(6):1346-1353. doi:10.11124/jbisrir-2017-003426.