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Robert J. Bridges, PhD

Professor and Director of Cystic Fibrosis Research

Research Projects

Dr. Bridges' primary area of research is on epithelial ion transport with a special focus on epithelial ion channels. His lab uses a wide range of electrophysiological methods and video imaging to study the regulation, pharmacology and biophysics of ion channels including CFTR, ENaC and various potassium channels. He collaborates with several pharmaceutical companies working toward the development of drugs for the treatment of Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. 

Publications

  • Adebamiro, A., Cheng, Y., Rao, U.S., Danahay, H., and Bridges, R.J. (2007). A segment of g ENaC mediates elastase activation of Na+ transport. J Gen Physiol. 130(6):611-629.
  • Adebamiro, A., Cheng, Y., Johnson, J.P. and Bridges, R.J. (2005). Endogenous protease activation of ENaC: Effect of serine protease inhibition on ENaC single channel properties. J. Gen. Physiol. 126(4):339-352.
  • Kreindler, J.L., Jackson, A., Kemp, P., Bridges, R.J., Danahay, H. (2004). Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract. Am. J. Physiol. Lung Cell Mol. Physiol. Epub.
  • Singh, A.K., Schultz, B.D., van Driessche, W., Bridges, R.J. (2004). Transepithelial fluctuation analysis of chloride secretion. J. Cyst Fibros. Suppl 2:127-132.
  • Bridges, R.J., Newton, B.B., Pilewski, J.M., Devor, D.C., Poll, C.T., and Hall, R.L. (2001). Na transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437. Am. J. Physiol. 281:L16-L23.
  • Devor, D.C., Bridges, R.J., and Pilewski, J.M. (2000). Pharmacological modulation of ion transport across wild-type and deltaF508-CFTR-expressing human bronchial epithelia. Am. J. Physiol. 279:C461-C479.
  • Schultz, B.D., Singh, A.K., Devor, D.C. and Bridges, R.J. (1999). Pharmacology of CFTR chloride channel activity. Physiological Reviews 79:S109-S144.
  • Devor, D. C., Singh, A.K., Lambert, L.C., DeLuca, A., Frizzell, R.A., and Bridges, R.J. (1999). Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. J. Gen Physiol. 113:743-760.