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Svetlana Dambaeva, MD, PhD

Research Assistant Professor, Associate Director of Clinical Immunology Laboratory

Dr. Dambaeva received her medical degree from Siberian State Medical University, Tomsk, Russia, in 1992 and started her career as a clinical laboratory physician in the Municipal Maternity Hospital, Ulan-Ude, Russia. In 2002 she earned a PhD degree in medical science from the prestigious Institute of Immunology in Moscow in the laboratory of Dr. Pinegin. She completed her postdoctoral training in Dr. Golos’s Lab at the University of Wisconsin, Madison in the Department of Obstetrics & Gynecology, studying the primate endometrial response to placental MHC class I molecules.

In 2008, Dr. Dambaeva became assistant scientist in the Department of Comparative Biosciences at the University of Wisconsin, where she continued her research in the reproductive immunology field. To further pursue her career in clinical diagnostic laboratory, Dr. Dambaeva completed a Medical Laboratory Immunology Fellowship program, accredited by the American Society of Microbiology, in the laboratory of Dr. Kenneth Beaman and in 2014 was board certified as a Diplomate by the American Board of Medical Laboratory Immunology (ABMLI).

In addition to being a member of the Chicago Medical School faculty, Dr. Dambaeva serves as assistant director of the Clinical Immunology Laboratory at Rosalind Franklin University.

RESEARCH

Dr. Dambaeva’s research interests include immune response at the maternal-fetal interface and analysis of immune mechanisms of infertility and recurrent pregnancy loss. Infertility and recurrent pregnancy losses affect millions Americans. Despite improvements in diagnostic assessment, no explanations have been found in many cases, although immune factors are often implied. Currently, with the focus on clinical immunology laboratory, Dr. Dambaeva’s goal is to develop and validate novel diagnostic tests that will help physicians to identify the immune etiology of pregnancy loss and infertility.

Endometrium is a unique tissue that undergoes cyclic changes. Innate lymphoid cells (ILC) are known to play a central role in tissue remodeling and homeostasis at mucosal and epithelial barrier surfaces, and were also detected in pregnant and non-pregnant endometrium (ILC1 and ILC3). Among factors secreted by ILC is IL-22, the cytokine that plays important role in proliferation and differentiation of cells at various epithelial surfaces and in prevention of preterm birth in mouse model. The characterization of factors involved in the regulation of ILC activity and the role of IL-22 in cycling and pregnant endometrium will advance the understanding of pathogenesis of pregnancy related disorders. SGK1 (serum/glucocorticoid-regulated kinase 1) and sodium levels, which are known to be involved in differentiation of IL-22 secreting Th17 cells, are studied in relation to regulation of IL-22 production in the endometrium. Moreover, the uncovering the relationship between endometrial NK cells, which are the most abundant cells in late luteal phase and early pregnancy endometrium, and classical ILC will provide important information on development and plasticity of ILC subsets. The determination of optimal balance between proinflammatory and homeostatic signals required for establishment of healthy pregnancy is a necessary step in the development of valid diagnostic test.

PEER REVIEWED PUBLICATIONS

  • Dambaeva SV, Lee DH, Sung N, Bao S, Gilman-Sachs A, Kwak-Kim J, Beaman KD. Recurrent pregnancy loss in women with killer cell immunoglobulin-like receptor KIR2DS1 is associated with an increased HLA-C2 allelic frequency. AJRI 2015,  doi:10.1111/aji.12453
  • Ota K, Dambaeva S, Kim MW, Han AR, Fukui A, Gilman-Sachs A, Beaman K, Kwak-Kim. J.1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses. Eur J Immunol. 2015 Nov;45(11):3188-99. doi: 10.1002/eji.201545541. .
  • Ota K, Yamagishi S, Kim M, Dambaeva S, Gilman-Sachs A, Beaman K, Kwak-Kim J. Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in recurrent pregnancy losses (RPL): possible participation of RAGE in RPL. Fertil Steril. 2014, 102(3):782-9. doi:10.1016/j.fertnstert.2014.06.010.
  • Ota K, Dambaeva S, Lee J, Gilman-Sachs A, Beaman K, Kwak-Kim J. Persistent high levels of IgM antiphospholipid antibodies in a patient with recurrent pregnancy losses and rheumatoid arthritis. Am J Reprod Immunol. 2014, (3):286-92. doi: 10.1111/aji.12196. Epub 2014 Jan 2.
  • Ota K, Dambaeva S, Han AR, Beaman K, Gilman-Sachs A, Kwak-Kim J. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod. 2014, 29(2):208-19. doi: 10.1093/humrep/det424. Epub 2013 Nov 24.
  • Dambaeva SV, Durning M, Rozner AE, Golos TG. Immunophenotype and Cytokine Profiles of Rhesus Monkey CD56bright and CD56dim Decidual Natural Killer Cells. Biol Reprod. 2012, 86(1):9, 1-10 [Epub ahead of print: 2011, Sep 7] PMID: 21900681
  • Giakoumopoulos, M., Siegfried, L.M., Dambaeva, S.V., Garthwaite, M.A., and Golos, T.G. Placental-derived mesenchyme influences chorionic gonadotropin and progesterone secretion of human embryonic stem cell-derived trophoblasts. Reproductive Sciences, 2010, 17(9):798-808
  • Rozner AE, Dambaeva SV, Drenzek JG, Durning M, Golos TG. Generation of macrophages from peripheral blood monocytes in the rhesus monkey. J of Immun Methods, 2009, 351(1-2): 36-40.
  • Bondarenko G.I, Dambaeva SV, Grendell RL, Hughes AL, Durning M, Garthwaite MA and Golos TG. Characterization of cynomolgus and vervet monkey placental MHC class I expression: Diversity of the nonhuman primate AG locus. Immunogenetics, 2009, 61(6): 431-442.
  • Drenzek J.C., Vidiguriene J., Vidiguris G., Grendell R.L., Dambaeva S.V., Durning M., and Golos T.G. Suppression of Mamu-AG by RNA interference. Am. J. Reprod. Immunol. 2009, 61:453-461.
  • Dambaeva SV, EE. Breburda, M Durning, MA Garthwaite and TG Golos. Characterization of decidual leukocyte populations in cynomolgus and vervet monkeys. J Reprod Immunol. 2009 80:57-69. DOI: 10.1016/j.jri.2008.12.006
  • Dambaeva SV, Bondarenko GI, Grendell RL, Kravitz RH, Durning M, Golos TG. Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta. Placenta, 2008, 29:58-70
  • Breburda EE, Dambaeva SV, Slukvin II, Golos TG. Selective distribution and pregnancy-specific expression of DC-SIGN at the maternal-fetal interface in the Rhesus Macaque: DC-SIGN is a putative marker of the recognition of pregnancy. Placenta, 2006, 27:11-21
  • Liu YP, Dambaeva SV, Dovzhenko OV, Garthwaite MA, Golos TG. Stable plasmid-based siRNA silencing of gene expression in human embryonic stem cells. Stem Cells Dev. 2005, 14:487-492 
  • Liu YP, Dovzhenko OV, Garthwaite MA, Dambaeva SV, Durning M, Pollastrini LM, Golos TG. Maintenance of pluripotency in human embryonic stem cells stably over-expressing enhanced green fluorescent protein. Stem Cells Dev. 2004, 13:636-645
  • Dyakonova VA, Dambaeva SV, Pinegin BV, Khaitov RM. Study of interaction between the polyoxidunium immunomodulator and the human immune system cells. Int Immunopharmacol. 2004, 15:1615-1623
  • Dambaeva SV, Mazurov DV, Golubeva NM, D’yakonova VA, Pinegin BV, Khaitov RM. Effect of Polyoxidonium on the Phagocytic Activity of Human Peripheral Blood Leukocytes. Russ J Immunol. 2003, 8:53-60
  • Dambaeva S, Kim K, Mazurov D, Deigin V. Effect of thymic peptides on the functional activity of the phagocytic cells of donor peripheral blood. Zh Microbiol Epidemiol Immunobiol. 2002, 6:55-59

BOOK CHAPTERS, REVIEW PAPERS, & OTHER PUBLICATIONS

  • Beaman KD, Jaiswal MK, Dambaeva S, Gilman-Sachs A. Future directions of clinical laboratory evaluation of pregnancy. Cell Mol Immunol. 2014, 11(6):582-8. doi: 10.1038/cmi.2014.62. Epub 2014 Jul 21. PMID:25042633
  • Kwak-Kim J, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, Beaman K, Kim JW, Gilman-Sachs A. Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. Am J Reprod Immunol. 2013, 69(6):596-607. doi: 10.1111/aji.12114. Epub 2013 Mar 25. PMID: 23521391
  • Golos TG, Bondarenko GI, Dambaeva SV, Breburda EE, Durning M. On the role of placental Major Histocompatibility Complex and decidual leukocytes in implantation and pregnancy success using non-human primate models. Int J Dev Biol 2010, 54:431-443
  • Golos TG, Bondarenko GI, Breburda EE, Dambaeva SV, Durning M, Slukvin II. Immune and trophoblast cells at the rhesus monkey maternal-fetal interface. Methods Mol Med. 2006, 122:93-108
  • Dambaeva SV, Mazurov DV, Golubeva NM, D’yakonova VA, Pinegin BV, Khaitov RM The effect of polyoxidonium on the phagocytic activity of human peripheral blood leukocytes. Centr Eur J Immunol 2003; 28(2): 47–53
  • Dambaeva S, Mazurov D, Pinegin B. Phagocytic system function in patients with chronic granulomatous disease. Immunologiya (Russian) 2002, 2:87-92.
  • Dambaeva S, Mazurov D, Pinegin B. An estimation of reactive form of oxygen production by laser flow cytometry method in peripheral blood human cells. Immunologiya (Russian) 2001, 6:58-61
  • Dambaeva S, Mazurov D, Golubeva N, Pinegin B. The influence of some immunomodulators on functional activity of donors peripheral blood phagocytic cells. Immunologiya (Russian) 2000, 6:15-20