MBCH 502 Clinical Molecular Cell Biology (5 credits)
Course Director Dr. Adrian Gross
The molecular and cellular processes common to all eukaryotic cells are studied. Nucleic acid and protein structure and function, gene expression, and cell cycle regulation are examined. Clinical aspects are integrated through small group problem-based learning sessions and clinical vignettes. A unique aspect of the course is the individual, self-teaching program that covers basic facts and concepts.
MBCH 505 A & B Medical Biochemistry
Course Director Dr. Marc Glucksman
The fundamental bases of biological reactions of important compounds in the normal and disease states of the human organism are studied. Emphasis is placed on the regulation and integration of metabolic processes as it relates to medicine. The course makes use of lectures, small groups and clinical conferences. This course utilizes an individual, self-teaching program to provide the students with an initial foundation of required knowledge.
MBCH 508 Clinical Genetics (3 credits)
Course Director Dr. David Mueller
Clinical Genetics uses lectures and small group learning to gain expertise in pedigree analysis including inheritance patterns, occurrence and recurrence risk determination, population genetics including Hardy-Weinberg law, founder effects, mutation-selection equilibrium, principles of gene therapy, genetic testing, counseling and ethics and genetic mechanisms.
MBCH 616 Crystallization of Membrane Proteins (3 credits)
Research with Drs. Choe, Kaplan or Lu
This course will teach the student cutting-edge approaches used in the over-expression and crystallization of clinically relevant membrane proteins. Techniques include vapor diffusion approaches, lipid cubic phase methodology, crystal manipulation, and manipulation and monitoring of detergent levels. The student will be actively involved in experimental design, execution, and data analysis.
MBCH 630 Protein Structure and Mechanism (3 credits)
Course Directors Drs. Choe and Lu
This is a course of lectures, student presentations, and seminars by outside speakers on aspects of medically relevant proteins and enzymes. The following subjects are covered: protein sequence methodology, disease states and drug design considerations, X-ray crystallography, computer graphic modeling, chemical and enzyme kinetics including regulatory kinetics, enzyme mechanisms, and chemical modification of enzymes.. Offered every other year, alternating with GBCH 544. Prerequisite: MBCH600A.
Original research projects are also offered in several faculty labs. Advanced Genetics as well as all graduate courses are available to medical students.