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Eugene L. Dimitrov, MD, PhD

Eugene L. Dimitrov, MD, PhD
Associate Professor

Physiology and Biophysics Discipline

Center for Neurobiology of Stress Resilience and Psychiatric Disorders

Dr. Eugene Dimitrov earned his medical degree in 1992, and he earned a PhD in neuroscience in 2007.

Research Projects

My research interests are focused on the interdigitation of stress and pain pathways. I use a systemic approach to examine the contribution of subsets of GABAergic neurons in amygdala to the generation of affective disorders. I use transgenic mice lines and apply technologies such as viral vectors and pharmacogenetics to discover and describe the function of various neurotransmitter systems on pain associated mood disorders.


  • Cardenas A, Caniglia J, Keljalic D, Dimitrov E. Sex Differences in the Development of Anxiodepressive-Like Behavior of Mice Subjected to Sciatic Nerve Cuffing. (March 2020) Pain, PMID: 32205527.
  • Andreoli, M., Marketkar, T., and Dimitrov E. Contribution of amygdala CRF neurons to chronic pain. (2017) Exp Neurol, 298(Pt A):1-12
  • Usdin T.B. and Dimitrov E. L.  The Effects of Extended Pain on Behavior: Recent Progress, (2016) Neuroscientist, 22(5):521-33
  • Dimitrov E., Tsuda, M. and Usdin T. B. Anxiety- And Depression-Like Behavior and Impaired Neurogenesis Evoked by Peripheral Neuropathy Persist Following Resolution of Prolonged Tactile Hypersensitivity, (2014) J Neuroscience, 34(37):12304-12
  • Dimitrov E. L., Kuo J., Kohno K. and Usdin T. B. Tuberoinfundibular Peptide of 39 Residues Control of Norepinephrine Release in Chronic and Inflammatory Pain, (2013) PNAS, 110(32):13156-61
  • Dimitrov E. L., Yanagawa, Y. and Usdin T. B. Forebrain GABAergic Projections to Locus Ceruleus in Mouse, (2013) J Comp Neurology, 521 (10):2373
  • Dobolyi A., Dimitrov E., Palkovits M. and Usdin T.B. The Neuroendocrine Functions of the Parathyroid Hormone 2 Receptor, (2012) Front Endocrinol (Lausanne), 3(121):1-10
  • Gao J. L., Schneider E. H., Dimitrov E. L., Haun F., Pham T. M., Mohammed A. H., Usdin T. B. and Murphy P.M. Reduced Fear Memory and Anxiety-like Behavior in Mice Lacking Formylpeptide Receptor 1, (2011) Behav Genetics, 41(5):724-733
  • Dimitrov E., Kim Y. and Usdin T. Regulation of Hypothalamic Signaling by Tuberoinfundibular Peptide of 39 Residues Is Critical for the Response to Cold: A Novel Peptidergic Mechanism of Thermoregulation, (2011) J Neuroscience, 31(49):18166-11179
  • Dimitrov E., Petrus E. and Usdin T. B. Tuberoinfundibular Peptide of 39 residues (TIP39) Signaling Modulates Acute and Tonic Nociception, (2010) Exp Neurology, 226: 68-83
  • Dimitrov E. and Usdin T. B. Tuberoinjundibular Peptide of 39 Residues Modulates the Mouse Hypothalamic-Pituitary-Adrenal Axis Via Paraventricular Glutamatergic Neurons, (2010) J Comp Neurology, 518(21): 4375-4395
  • Dimitrov E., Bago A. G., Saunders R., Seress L., Palkovits M., Usdin T. B. and Dobolyi A. Parathyroid Hormone 2 Receptor and Its Endogenous Ligand Tuberoinfundibular Peptide of 39 Residues are Concentrated in Endocrine, Viscerosecretory and Auditory Brain Regions in Macaque and Human, (2009) Neuroscience, 162:128-147
  • Dimitrov E. L., DeJoseph M. R., Brownfield M. S. and Urban J. H. Involvement of Neuropeptide Y Y1 Receptors in the Regulation of Neuroendocrine Corticotropin­ Releasing Hormone Neuronal Activity, (2007) Endocrinology, 148(8): 3666 -3673