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Center for Neurodegenerative Diseases & Therapeutics Diseases


  • Robert Marr
    • Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. (2018) Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production. Mol Ther. 26(6):1539-1551. PMID: 29628304
    • Lim PH, Wert SL, Tunc-Ozcan E, Marr R, Ferreira A, Redei EE. (2018) Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behav Brain Res. pii: S0166-4328(17)31740-0. PMID: 29490235
    • AJ Hinrich, FM Jodelka, JL Chang, D Brutman, A Bruno, CA Briggs, BD. James, GE Stutzmann, DA Bennett, SA Miller, F Rigo, RA Marr, ML Hastings (2015). Therapeutic correction of apoER2 splicing in Alzheimer’s disease mice using antisense oligonucleotides. EMBO Molecular Medicine, 8(4):328-45. PMID: 26902204
    • JA Bonds, Y Kuttner-Hirshler, N Bartolotti, MK Tobin; M Pizzi, RA Marr, O Lazarov (2015). Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory. PLoS One, 10(6):e0131266. PMID: 26098332
  • Grace E. Stutzmann
    • Chakroborty S, Hill E. Christian DT, Helfrich R, Riley S, Kapecki N, Mustaly S, Seiler FA, Schneider C, Peterson DA, West AR, Vertel BM, Frost WN, Stutzmann GE. (2019) Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease. Molecular Neurodegeneration, 22;14(1):7. PMID: 30670054
    • Schrank S, Barrington N, Stutzmann GE (2019) ‘Calcium handling defects and neurodegenerative disease’ In Calcium, Second Edition. Editors: Martin D. Bootman, Geert Bultynck, Grace E. Stutzmann, and Michael J. Berridge. Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 499-524. PMID: 31427373
    • Mustaly S, Littlefield A, Stutzmann GE (2018) Calcium signaling deficits in glia and autophagic pathways contributing to neurodegenerative disease. 29(12): 1158-1175. PMID: 29634342
    • Briggs CA, Chakroborty S, Stutzmann GE (2017) Emerging pathways driving early synaptic pathology in Alzheimer’s disease. Biochem Biophys Res Commun. 483(4):988-997. PMID: 27659710
    • Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR (2017) Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits. Acta Neuropathol, 134(5):749-767. doi: 10.1007/s00401-017-1733-7 PMID: 28631094
    • Chakroborty S, Kim J, Schneider C, West A, Stutzmann GE (2015) Nitric oxide signaling is recruited as a compensatory mechanism for sustaining synaptic plasticity in Alzheimer’s disease mice. Journal of Neuroscience, 35(17), 6893-902. doi: 10.1523/JNEUROSCI.4002-14.2015 PMID: 25926464

Brain injury

  • Robert Marr
    • F Klempin, RA Marr, DA Peterson (2012). Modification of Pax6 and Olig2 in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations. Stem Cells, 30(3):500-9. PMID: 22162276
  • Daniel A. Peterson
    • Jamnia N, Urban JH, Stutzmann GE, Chiren SG, Reisenbigler E, Marr R, Peterson DA, Kozlowski DA. (2017) A Clinically Relevant Closed-Head Model of Single and Repeat Concussive Injury in the Adult Rat Using a Controlled Cortical Impact Device. Journal of Neurotrauma 3:1351-1363.
    • Doerr J, Schwarz MK, Wiedermann D, Leinhaas A, Jakobs A, Schloen F, Schwarz I, Diedenhofen M, Braun NC, Koch P, Peterson DA, Kubitscheck U, Hoehn M, Brüstle O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nature Communications 8:14162. 
    • Kuhn HG, Eisch AJ, Spalding K, Peterson DA. (2016) Detection and Phenotypic Characterization of Adult Neurogenesis. Cold Spring Harbor Perspectives in Biology 8:a025981.
  • Grace E. Stutzmann
    • Jamnia N, Urban JH, Stutzmann GE, Chiren S, Reisenbigler E, Marr R, Peterson DA, Kozlowski DA (2016) A clinically relevant closed-head model of single and repeat concussive injury in the adult rat using a controlled cortical impact device. J Neurotrauma. 34(7):1351-1363. PMID: 27762651
    • Shim S, Stutzmann GE (2016) Inhibition of glycogen synthase kinase-3: an emerging target in the treatment of traumatic brain injury. Journal of Neurotrauma. 33(23):2065-2076. PMID: 26979735



  • Judith A. Potashkin
    • Santiago JA, Bottero V, Potashkin JA. (2018) Evaluation of RNA Blood Biomarkers in the Parkinson's Disease Biomarkers Program. Front Aging Neurosci. 10:157.
    • Santiago JA, Bottero V, Potashkin JA. (2017) Biological and Clinical Implications of Comorbidities in Parkinson's Disease. Front Aging Neurosci. 9:394.
    • Santiago JA, Potashkin JA. (2017) Evaluation of RNA Blood Biomarkers in Individuals at Risk of Parkinson's Disease. J Parkinsons Dis. 7:653.
    • Santiago JA, Bottero V, Potashkin JA. (2017) Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology. Front Aging Neurosci. 9:166
    • Katrina Gwinn, Karen David, Christine Swanson-Fischer, Roger Albin, Coryse St. Hillaire-Clark, Beth-Anne Sieber, Codrin Lungu, F. DuBois Bowman, Roy N. Alcalay, Debra Babcock, Ted M. Dawson, Richard B. Dewey, Tatiana Foroud, Dwight German, Xuemei Huang, Vlad Petyuk, Judith A. Potashkin, Rachel Saunders-Pullman, Margaret Sutherland, David Walt, Andrew B. West, Jing Zhang, Alice Chen-Plotkin, Clemens R. Scherzer, David Vaillancourt, and Liana S. Rosenthal. Parkinson’s disease biomarkers: Perspective from the NINDS Parkinson’s disease biomarkers program. Biomark Med. 11, 451-473.

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