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Recent Publications

Neil Bradbury

  • Mórotz GM, Bradbury NA, Caluseriu O, et al. A revised nomenclature for the lemur family of protein kinases. Commun Biol. 2024;7(1):57. Published 2024 Jan 8. doi:10.1038/s42003-023-05671-8
  • Bradbury NA. Do I have your attention? Attention and engagement: What are they, and do I want them?. Adv Physiol Educ. 2023;47(2):318-325. doi:10.1152/advan.00022.2023
  • Holland A, Bradbury NA. Did you forget your cell sex? An update on the inclusion of sex as a variable in AJP-Cell Physiology. Am J Physiol Cell Physiol. 2023;324(4):C910-C926. doi:10.1152/ajpcell.00434.2022
  • Bradbury NA. Chapter 15. All cells have a sex: Sex chromosome function at the cellular level. In: Legato MJ (ed). Principles of Gender-Specific Medicine in the genomic era. 4th Edition.  Elsevier Academic Press, pp 231-264. ISBN 978-0-323-88534-8 April 2023.
  • Bradbury NA. Cystic Fibrosis: In Encyclopedia of Cell Biology 2nd Edition. Volume 4 Systems, Translational and Specialized Cell Aspects of Cell Biology. Elsevier. pp. 563-588. ISBN 978-0-12-821624-8, Oct 2022.

Robert J. Bridges

  • Michaels W.E., Bridges R.J., Hastings M.L. (2020) Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. Nucleic Acids Research, 2020 1–14 doi: 10.1093/nar/gkaa490
  • Clancy J.P., Cotton C.U., Donaldson S.H., Solomon G.M., VanDevanter D.R., Boyle M.P., Gentzsch M., Nick J.A., Illek B., Wallenburg J.C., Sorscher E.J., Amaral M.D., Beekman J.M., Naren A.P., Bridges R.J., Thomas P.J., Cutting G., Rowe S., Durmowicz A.G., Mense M., Boeck K.D., Skach W., et al. (2018) CFTR modulator theratyping: Current status, gaps and future directions. J Cyst Fibros. Jun 19. pii: S1569-1993(18)30585-X. [Epub ahead of print] Review.
  • Robert J. Bridges and Neil A. Bradbury. Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator and Drugs: Insights from Cellular Trafficking. Handbook Exp Pharmacol. 245:385-425, January 2018.
  • Zeng M., Szymczak M., Ahuja M., Zheng C., Yin H., Swaim W., Chiorini J.A., Bridges R.J., and Muallem S. (2017) Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 153:1148-1159.
  • Xue X., Mutyam V., Thakerar A., Mobley J., Bridges R.J., Rowe S.M., Keeling K.M., and Bedwell D.M. (2017) Identification of the amino acids inserted during suppression of CFTR nonsense mutations and determination of their functional consequences. Hum Mol Genet. 26:3116-3129.

Weihang (Valerie) Chai

  • Knowles S, Chai W. Conditional Depletion of STN1 in Mouse Embryonic Fibroblasts. Bio Protoc. 2024;14(8):e4977. Published 2024 Apr 20. doi:10.21769/BioProtoc.4977
  • Sang PB, Jaiswal RK, Lyu X, Chai W. Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21. Nucleic Acids Res. 2024;52(7):3778-3793. doi:10.1093/nar/gkae078
  • Jaiswal, R.K., Lei, K-H., Chastain, M., Wang, Y., Shiva, O., Li, S., You, Z., Chi, P., Chai, W. CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection. Nature Comm. 14, Article number: 7882 (2023). PMID: 38036565
  • Nguyen, D.D., Kim, E., Le, N.T., Ding, X., Jaiswal, R.K., Kostlan, R.J., Nguyen, T.N.T., Shiva, O., Le, M.T., Chai, W. (2023) Deficiency of mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Science Advances 9 (19): eadd8023. PMID: 37163605 (IF: 14.98)
  • Lei, K-H., Yang, H-L., Nguyen, D-D, Chang, H-Y, Yeh, H-Y., Lee, T-Y., Lyu, X., Chai, W., Li, W-L., Chi, P. (2021) Crosstalk between CST and RPA regulates RAD51 activity during replication stress. Nature Comm. 12(1):6412. PMID: 34741010. (IF: 14.919)
  • Lyu, X., Sang, P. S., Chai, W. (2021) CST in maintaining genome stability: beyond telomeres. DNA Repair. 102: 103104. (Review) 
  • Lyu, X., Lei, K-H., Sang, P. S., Shiva, O., Chastain, M., Chi, P., Chai, W. (2021) Human CST complex protects replication fork stability by directly blocking MRE11 degradation of nascent strand DNA. EMBO J. doi: 10.15252/embj.2019103654
  • Lyu, X., Chastain, M., Chai, W. (2019) Genome-wide mapping and profiling of gH2AX binding hotspots in response to different replication stress inducers. BMC Genomics. 20 (1): 579-592.
  • Wang, Y., Chai, W. (2018) Pathogenic CTC1 mutations cause global genome instabilities under replication stress. Nucleic Acids Res. 46 (8): 3981-3992. (IF: 10.162)
  • Huang, C., Jia, P., Chastain, M., Shiva, O., Dai, X., Chai, W. (2017) The Human CTC1/STN1/TEN1 Complex Localizes in ALT-Associated PML Bodies and Regulates Telomere maintenance in ALT cancer cells. Exp Cell Res. 355(2):95-104.
  • Jia, P., Chastain, M., Zou, Y., Her, C., Chai, W. (2017) Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Res. 45(3):1219-1232. doi: 10.1093/nar/gkw1170.
  • Chastain, M., Zhou, Q., Shiva, O., Fadri-Moskwik, M., Whitmore, L., Jia, P., Dai, X., Huang, C., Ye, P., Chai, W. (2016) Human CST facilitates genome-wide RAD51 recruitment to GC-rich repetitive sequences in response to replication stress.  Cell Reports. 16(5):1300-14

David M. Mueller

  • Sharma S, Luo M, Patel H, Mueller DM, Liao M. Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1-Fo coupling. Nat Struct Mol Biol. 2024;31(4):657-666. doi:10.1038/s41594-024-01219-4
  • Chouhan S, Sawant M, Weimholt C, et al. TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability. Autophagy. 2023;19(3):1000-1025. doi:10.1080/15548627.2022.2103961
  • Su X, Dautant A, Rak M, et al. The pathogenic m.8993 T > G mutation in mitochondrial ATP6 gene prevents proton release from the subunit c-ring rotor of ATP synthase. Hum Mol Genet. 2021;30(5):381-392. doi:10.1093/hmg/ddab043
  • Moya-Mendez ME, Mueller DM, Pratt M, et al. Early onset severe ATP1A2 epileptic encephalopathy: Clinical characteristics and underlying mutations. Epilepsy Behav. 2021;116:107732. doi:10.1016/j.yebeh.2020.107732
  • Prange L, Pratt M, Herman K, et al. D-DEMØ, a distinct phenotype caused by ATP1A3 mutations. Neurol Genet. 2020;6(5):e466. Published 2020 Aug 4. doi:10.1212/NXG.0000000000000466
  • Luo M, Zhou W, Patel H, et al. Bedaquiline inhibits the yeast and human mitochondrial ATP synthases. Commun Biol. 2020;3(1):452. Published 2020 Aug 19. doi:10.1038/s42003-020-01173-z