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Center for Cancer Cell Biology, Immunology and Infection Diseases

Cancer

  • Kenneth D. Beaman
    • Kulshrestha A, Katara GK, Ibrahim SA, Riehl VE, Schneiderman S, Bilal M, Young AN, Levine S, Fleetwood S, Dolan J, Gilman-Sachs A, Beaman KD. In vivo anti-V-ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses. Mol Oncol. 2020 Oct;14(10):2436-2454. doi: 10.1002/1878-0261.12782. Epub 2020 Sep 10. PMID: 32797726; PMCID: PMC7530789.
    • Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, Kwak-Kim J, Beaman K, Dambaeva SV. Prevalence of HHV-6 in endometrium from women with recurrent implantation failure. Am J Reprod Immunol. 2018 Jul;80(1):e12862. doi: 10.1111/aji.12862. Epub 2018 Apr 17.
    • Pamarthy S, Kulshrestha A, Katara GK, Beaman KD. The curious case of vacuolar ATPase: regulation of signaling pathways. Mol Cancer. 2018 Feb 15;17(1):41. doi: 10.1186/s12943-018-0811-3. 
    • Kulshrestha A, Katara GK, Ibrahim SA, Patil R, Patil SA, Beaman KD. Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells. Oncotarget. 2017 May 2;8(40):67017-67028. doi: 10.18632/oncotarget.17549. eCollection 2017 Sep 15.
  • Mirek Dundr
    • Bártová E, Legartová S., Suchánková S., Dundr M., Krejci J. (2018) A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair. Aging. doi: 10.18632/aging.101917
    • Sawyer IA, Bartek J, Dundr M. Phase separated microenvironments inside the nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing. Semin Cell Dev Biol. 2018 Jul 11. pii: S1084-9521(18)30120-4. doi: 10.1016/j.semcdb.2018.07.001. [Epub ahead of print] Review. 
    • Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Nucleic Acids Res. 2018 May 4;46(8):4241-4255. doi: 10.1093/nar/gky100. 
    • Sawyer IA, Dundr M. Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture. Chromosoma. 2017 Oct;126(5):541-557. doi: 10.1007/s00412-017-0632-y. Epub 2017 Jun 7. 
    • Sawyer IA, Sturgill D, Sung M-H, Hager GL, Dundr M. (2016). Cajal body function in genome organization and transcriptome diversity. BioEssays 38: 1197-1208.
  • David N. Everly
    • Kirsten Holthusen, Pooja Talaty, and David N. Everly Jr., “Regulation of Latent Membrane Protein 1 Signaling through Interaction with Cytoskeletal Proteins.” J. Virology, 89:7277-7290, 2015.
    • Ansari M.A., Singh V.V., Dutta S., Veettil M.V., Dutta D., Chikoti L., Lu J., Everly D., Chandran B., “Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells.” J. Virology, 87: 8606-8623, 2013.
  • Alice Gilman-Sachs
    • Kulshrestha A, Katara GK, Ibrahim SA, Riehl VE, Schneiderman S, Bilal M, Young AN, Levine S, Fleetwood S, Dolan J, Gilman-Sachs A, Beaman KD. In vivo anti-V-ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses. Mol Oncol. 2020 Oct;14(10):2436-2454. doi: 10.1002/1878-0261.12782. Epub 2020 Sep 10. PMID: 32797726; PMCID: PMC7530789.
    • Katara GK, Kulshrestha A, Mao L, Wang X, Sahoo M, Ibrahim S, Pamarthy S, Suzue K, Shekhawat GS, Gilman-Sachs A, Beaman KD. Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.  Mol Oncol. 2018 Feb;12(2):208-223. doi: 10.1002/1878-0261.12159. Epub 2017 Dec 12. 
    • Patil R, Kulshrestha A, Tikoo A, Fleetwood S, Katara G, Kolli B, Seibel W, Gilman-Sachs A, Patil SA, Beaman KD.  Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H⁺)-ATPase Inhibitors.  Molecules. 2017 Sep 16;22(9). pii: E1559. doi: 10.3390/molecules22091559.
  • Johnny J. He
    • Liu, Y., Huang, X, Timani, K. A., Broxmeyer H. E., He, J. J. (2018) Regulation of Constitutive Tip110 Expression in Human Cord Blood CD34+ Cells Through Selective Usage of the Proximal and Distal Polyadenylation Sites Within the 3′Untranslated Region. Stem Cells Dev. 27:566-576.
    • Timani, K., Guriffy, B., Liu, Y., Mohanmad, K.S. and He, J. J. (2018) Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. Molecular Cancer Aug 17;17(1):124. doi: 10.1186/s12943-018-0868-z.
    • Liu, Y., Huang, X, Timani, K. A., Broxmeyer H. E., He, J. J. (2017) miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells. Oncotarget 9:4823-4832.
    • Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. and He, J. J.  Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Stem Cells 35:1674-1686.
  • Gustavo J. Martinez
    • Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR.  Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin.  J Immunol. 2018 May 15;200(10):3647-3661. doi: 10.4049/jimmunol.1701220. Epub 2018 Apr 16.
    • Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW.  The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.  Nat Immunol. 2017 Jul;18(7):791-799. doi: 10.1038/ni.3755. Epub 2017 May 22.
  • Neelam Sharma-Walia
    • Lee BR, Paing MH, Sharma-Walia N. Cyclopentenone Prostaglandins: Biologically Active Lipid Mediators Targeting Inflammation. Front Physiol. 2021 Jul 15;12:640374. doi: 10.3389/fphys.2021.640374. PMID: 34335286; PMCID: PMC8320392.
    • Alsterda A, Asha K, Powrozek O, Repak M, Goswami S, Dunn AM, Memmel HC, Sharma-Walia N. Salubrinal Exposes Anticancer Properties in Inflammatory Breast Cancer Cells by Manipulating the Endoplasmic Reticulum Stress Pathway. Front Oncol. 2021 May 20;11:654940. doi: 10.3389/fonc.2021.654940. PMID: 34094947; PMCID: PMC8173155.
    • Asha K, Sharma-Walia N. Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections. Front Cell Infect Microbiol. 2021 Mar 19;11:603309. doi: 10.3389/fcimb.2021.603309. PMID: 33816328; PMCID: PMC8017445.
    • Iriana S, Asha K, Repak M, Sharma-Walia N. Hedgehog Signaling: Implications in Cancers and Viral Infections. Int J Mol Sci. 2021 Jan 21;22(3):1042. doi: 10.3390/ijms22031042. PMID: 33494284; PMCID: PMC7864517.
    • Valiya Veettil, M., G. Krishna, A. Roy, A. Ghosh, D. Dutta, B. Kumar, S. Chakraborty, A. T. Raveendran, N Sharma-Walia, B. Chandran. Kaposi's sarcoma Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells. J Virol., 2020. 94(8): e01692-19. PMCID: PMC7108831.
    • Young KE, Flaherty S, Woodman KM, Sharma-Walia N, Reynolds JM. Fatty acid synthase regulates the pathogenicity of Th17 cells. J Leukoc Biol. 2017 Nov;102(5):1229-1235. doi: 10.1189/jlb.3AB0417-159RR. Epub 2017 Aug 28.
    • Chandrasekharan JA, Huang XM, Hwang A, Sharma-Walia N. Altering the anti-inflammatory lipoxin microenvironment: a new insight into KSHV pathogenesis. J. Virol. 2016 Sep 28. pii: JVI.01491-16.
    • Chandrasekharan JA, Marginean A, Sharma-Walia N. An insight into the role of arachidonic acid derived lipid mediators in virus associated pathogenesis and malignancies. Prostaglandins Other Lipid Mediat. 2016 Jul 20. pii: S1098-8823(16)30082-X. doi: 10.1016/j.prostaglandins.2016.07.009 
    • Goswami S, Sharma-Walia N. Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. Oncotarget. 2016 Jun 6. doi: 10.18632/oncotarget.9835.
  • Carl White

Fibrosis

  • Bruce Riser
    • B.L. Riser, F. Najmabadi, K. Garchow, J.L. Barnes, Peterson, D.R., and E. J. Sukowski. Treatment with the matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol. 2014 Nov;184(11):2908-21. doi: 10.1016/j.ajpath.2014.07.009. Epub 2014 Sep 2.

Infection

  • Kwang Poo Chang
    • Viana SM, Celes FS, Ramirez L, Kolli B, Ng DKP, Chang KP, de Oliveira CI. Photodynamic Vaccination of BALB/c Mice for Prophylaxis of Cutaneous Leishmaniasis Caused by Leishmania amazonensis. Front Microbiol. 2018 Feb 6;9:165. doi: 10.3389/fmicb.2018.00165. eCollection 2018.
    • Lun ZR, Wu MS, Chen YF, Wang JY, Zhou XN, Liao LF, Chen JP, Chow LM, Chang KP. (2015) Visceral Leishmaniasis in China: an Endemic Disease under Control. Clin Microbiol Rev. 28:987-1004.
    • Chang, KP. (2013) Forward “Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments”, Ponte-Sucre, Alicia; Diaz, Emilia; Padrón-Nieves, Maritza (Eds.) XIV, Springer
  • Johnny J. He
    • Zhao X, Wilson K, Uteshev V, He JJ. Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology. Brain. 2021 Jul 1:awab251. doi: 10.1093/brain/awab251. Epub ahead of print. PMID: 34196664.
    • Zhao X, Fan Y, Vann PH, Wong JM, Sumien N, He JJ. Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging. Aging Dis. 2020 Feb 1;11(1):93-107. doi: 10.14336/AD.2019.0323. PMID: 32010484; PMCID: PMC6961778.
    • Fan, Y., Gao, X., Chen, J., Liu, Y. and He, J. J. (2016) HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway. Journal of Neuroscience 36:11362-11373. 
    • Liu, Z., and He, J. J. (2013) Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection, and Replication and Their Requirement for HCV Receptors. Journal of Virology 87:8545-8558. 
    • Henao-Mejia, J., Liu, Y., Park, I-W., Zhang, J., Sanford, J. and He, J. J. (2009) Suppression of HIV-1 Nef Translation by Sam68 Mutant-Induced Stress Granules and nef mRNA Sequestration. Molecular Cell 33:87-96.
    • Liu, Y., Liu, H., Kim, B. O., Nath, A., Li, J., Blum, J., and He, J. J. (2004) CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose Receptor. Journal of Virology 78:4121-4133.
    • Kim, B. O., Liu, Y., Xu, Z. C., Ruan, Y., Schantz, L., and He, J. J. (2003) Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline. American Journal of Pathology 162:1693-1707.
    • Liu, Y., Jones, M., Huntington, C.E., Bu, G., Laribee, N., Moir, R., Tanzi, R., Nath, A., and He J. J. (2000) Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine 6:1380-1387.

Inflammatory & Autoimmune Diseases

  • Gustavo J. Martinez
    • Marks KE, Flaherty S, Patterson KM, Stratton M, Martinez GJ, Reynolds JM. Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration. Cell Rep. 2021 Jun 29;35(13):109303. doi: 10.1016/j.celrep.2021.109303. PMID: 34192530; PMCID: PMC8270556.
    • Tanaka K, Martinez GJ, Yan X, et al. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. Cell Rep. 2018 May 22;23(8):2318-2329. doi: 10.1016/j.celrep.2018.04.088.
    • Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity. 2017 Dec 19;47(6):1182-1196.e10. doi: 10.1016/j.immuni.2017.11.012.
    • Martinez GJ*, Hu JK, Pereira RM, Crampton JS, Togher S, Bild N, Crotty S, and Rao A. Cutting Edge: NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection. J Immunol. 2016 Mar 1;196(5):2015-9. doi: 10.4049/jimmunol.1501841. Epub 2016 Feb 5.
  • Joseph Reynolds

Inflammatory & Infectious Diseases

  • Fabio Re
    • Wang J, Sahoo M, Lantier L, Warawa J, Cordero H, Deobald K, Re F.  Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.  PLoS Pathog. 2018 May 23;14(5):e1007105. doi: 10.1371/journal.ppat.1007105. eCollection 2018 May.
    • del Barrio L., Sahoo M., Lantier L., Reynolds J.M., Ceballos-Olvera I., Re F. (2015) Production of anti-LPS IgM by B1a B cells depends on IL-1β and is protective against lung infection with Francisella tularensis LVS. PLoS Pathog 11(3): e1004706. doi:10.1371/journal.ppat.1004706
    • Sahoo, M., del Barrio, L., Miller, M.A., and Re, F. (2014) Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with Burkholderia species. PLoS Pathog. 10(8): e1004327. doi:10.1371/journal.ppat.1004327. PMID:25166912

Metabolic Disease - Obesity

Muscular Dystrophy

Musculoskeletal

  • Joseph X. DiMario
    • DiMario JX. (2018) KLF10 Gene Expression Modulates Fibrosis in Dystrophic Skeletal Muscle. Am J Pathol. 188:1263-1275.
    • Hatch K, Pabon A, DiMario JX. (2017) EMX2 activates slow myosin heavy chain 2 gene expression in embryonic muscle fibers. Mech Dev. 147:8-16.
    • Cavanaugh E, DiMario JX. (2017) Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation. Gene. 617:24-31.

Reproductive health

Vaccine

  • Kwang Poo Chang
    • Sharma R, Viana SM, Ng DKP, Kolli BK, Chang KP, de Oliveira CI. Photodynamic inactivation of Leishmania braziliensis doubly sensitized with uroporphyrin and diamino-phthalocyanine activates effector functions of macrophages in vitro. Sci Rep. 2020 Oct 13;10(1):17065. doi: 10.1038/s41598-020-74154-1. PMID: 33051524; PMCID: PMC7555832.
    • Chang, KP, Kolli BK, New Light group (2016) New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasit Vectors. 9:396.
    • Chang, KP. (2014) Vaccination for Disease Prevention and Control: The Necessity of Renewed Emphasis and New Approaches. J Immunol Immunotech. 1: 1-4.