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Center for Cancer Cell Biology, Immunology and Infection Diseases

Cancer

  • Kenneth D. Beaman
    • Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, Kwak-Kim J, Beaman K, Dambaeva SV. Prevalence of HHV-6 in endometrium from women with recurrent implantation failure. Am J Reprod Immunol. 2018 Jul;80(1):e12862. doi: 10.1111/aji.12862. Epub 2018 Apr 17.
    • Pamarthy S, Kulshrestha A, Katara GK, Beaman KD. The curious case of vacuolar ATPase: regulation of signaling pathways. Mol Cancer. 2018 Feb 15;17(1):41. doi: 10.1186/s12943-018-0811-3. 
    • Kulshrestha A, Katara GK, Ibrahim SA, Patil R, Patil SA, Beaman KD. Microtubule inhibitor, SP-6-27 inhibits angiogenesis and induces apoptosis in ovarian cancer cells. Oncotarget. 2017 May 2;8(40):67017-67028. doi: 10.18632/oncotarget.17549. eCollection 2017 Sep 15.
  • Mirek Dundr
    • Bártová E, Legartová S., Suchánková S., Dundr M., Krejci J. (2018) A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair. Aging. doi: 10.18632/aging.101917
    • Sawyer IA, Bartek J, Dundr M. Phase separated microenvironments inside the nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing. Semin Cell Dev Biol. 2018 Jul 11. pii: S1084-9521(18)30120-4. doi: 10.1016/j.semcdb.2018.07.001. [Epub ahead of print] Review. 
    • Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Nucleic Acids Res. 2018 May 4;46(8):4241-4255. doi: 10.1093/nar/gky100. 
    • Sawyer IA, Dundr M. Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture. Chromosoma. 2017 Oct;126(5):541-557. doi: 10.1007/s00412-017-0632-y. Epub 2017 Jun 7. 
    • Sawyer IA, Sturgill D, Sung M-H, Hager GL, Dundr M. (2016). Cajal body function in genome organization and transcriptome diversity. BioEssays 38: 1197-1208.
  • David N. Everly
    • Kirsten Holthusen, Pooja Talaty, and David N. Everly Jr., “Regulation of Latent Membrane Protein 1 Signaling through Interaction with Cytoskeletal Proteins.” J. Virology, 89:7277-7290, 2015.
    • Ansari M.A., Singh V.V., Dutta S., Veettil M.V., Dutta D., Chikoti L., Lu J., Everly D., Chandran B., “Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells.” J. Virology, 87: 8606-8623, 2013.
  • Alice Gilman-Sachs
    • Katara GK, Kulshrestha A, Mao L, Wang X, Sahoo M, Ibrahim S, Pamarthy S, Suzue K, Shekhawat GS, Gilman-Sachs A, Beaman KD. Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer.  Mol Oncol. 2018 Feb;12(2):208-223. doi: 10.1002/1878-0261.12159. Epub 2017 Dec 12. 
    • Patil R, Kulshrestha A, Tikoo A, Fleetwood S, Katara G, Kolli B, Seibel W, Gilman-Sachs A, Patil SA, Beaman KD.  Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H⁺)-ATPase Inhibitors.  Molecules. 2017 Sep 16;22(9). pii: E1559. doi: 10.3390/molecules22091559.
  • Johnny J. He
    • Liu, Y., Huang, X, Timani, K. A., Broxmeyer H. E., He, J. J. (2018) Regulation of Constitutive Tip110 Expression in Human Cord Blood CD34+ Cells Through Selective Usage of the Proximal and Distal Polyadenylation Sites Within the 3′Untranslated Region. Stem Cells Dev. 27:566-576.
    • Timani, K., Guriffy, B., Liu, Y., Mohanmad, K.S. and He, J. J. (2018) Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. Molecular Cancer Aug 17;17(1):124. doi: 10.1186/s12943-018-0868-z.
    • Liu, Y., Huang, X, Timani, K. A., Broxmeyer H. E., He, J. J. (2017) miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells. Oncotarget 9:4823-4832.
    • Whitmill, A., Liu, Y., Timani, K. A., Niu, Y. and He, J. J.  Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Stem Cells 35:1674-1686.
  • Gustavo J. Martinez
    • Marangoni F, Zhang R, Mani V, Thelen M, Ali Akbar NJ, Warner RD, Äijö T, Zappulli V, Martinez GJ, Turka LA, Mempel TR.  Tumor Tolerance-Promoting Function of Regulatory T Cells Is Optimized by CD28, but Strictly Dependent on Calcineurin.  J Immunol. 2018 May 15;200(10):3647-3661. doi: 10.4049/jimmunol.1701220. Epub 2018 Apr 16.
    • Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW.  The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.  Nat Immunol. 2017 Jul;18(7):791-799. doi: 10.1038/ni.3755. Epub 2017 May 22.
  • Neelam Sharma-Walia
    • Alsterda A, Asha K, Powrozek O, Repak M, Goswami S, Dunn AM, Memmel HC and Sharma-Walia N. Salubrinal Exposes Anticancer Properties in Inflammatory Breast Cancer Cells by Manipulating the Endoplasmic Reticulum Stress Pathway. Front. Oncol. | https://doi.org/10.3389/fonc.2021.654940
    • Iriana S, Asha K, Repak M, Sharma-Walia N. Hedgehog Signaling: Implications in Cancers and Viral Infections. Int J Mol Sci. 2021. doi: 10.3390/ijms22031042. PMID: 33494284. Review
    • Valiya Veettil, M., G. Krishna, A. Roy, A. Ghosh, D. Dutta, B. Kumar, S. Chakraborty, A. T. Raveendran, N Sharma-Walia, B. Chandran. Kaposi's sarcoma Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells. J Virol., 2020. 94(8): e01692-19. PMCID: PMC7108831.
    • Young KE, Flaherty S, Woodman KM, Sharma-Walia N, Reynolds JM. Fatty acid synthase regulates the pathogenicity of Th17 cells. J Leukoc Biol. 2017 Nov;102(5):1229-1235. doi: 10.1189/jlb.3AB0417-159RR. Epub 2017 Aug 28.
    • Chandrasekharan JA, Huang XM, Hwang A, Sharma-Walia N. Altering the anti-inflammatory lipoxin microenvironment: a new insight into KSHV pathogenesis. J. Virol. 2016 Sep 28. pii: JVI.01491-16.
    • Chandrasekharan JA, Marginean A, Sharma-Walia N. An insight into the role of arachidonic acid derived lipid mediators in virus associated pathogenesis and malignancies. Prostaglandins Other Lipid Mediat. 2016 Jul 20. pii: S1098-8823(16)30082-X. doi: 10.1016/j.prostaglandins.2016.07.009 
    • Goswami S, Sharma-Walia N. Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. Oncotarget. 2016 Jun 6. doi: 10.18632/oncotarget.9835.
  • Carl White

Fibrosis

  • Bruce Riser
    • B.L. Riser, F. Najmabadi, K. Garchow, J.L. Barnes, Peterson, D.R., and E. J. Sukowski. Treatment with the matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol. 2014 Nov;184(11):2908-21. doi: 10.1016/j.ajpath.2014.07.009. Epub 2014 Sep 2.

Infection

  • Kwang Poo Chang
    • Viana SM, Celes FS, Ramirez L, Kolli B, Ng DKP, Chang KP, de Oliveira CI. Photodynamic Vaccination of BALB/c Mice for Prophylaxis of Cutaneous Leishmaniasis Caused by Leishmania amazonensis. Front Microbiol. 2018 Feb 6;9:165. doi: 10.3389/fmicb.2018.00165. eCollection 2018.
    • Lun ZR, Wu MS, Chen YF, Wang JY, Zhou XN, Liao LF, Chen JP, Chow LM, Chang KP. (2015) Visceral Leishmaniasis in China: an Endemic Disease under Control. Clin Microbiol Rev. 28:987-1004.
    • Chang, KP. (2013) Forward “Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments”, Ponte-Sucre, Alicia; Diaz, Emilia; Padrón-Nieves, Maritza (Eds.) XIV, Springer
  • Johnny J. He
    • Zhao X, Wilson K, Uteshev V, He JJ. Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology. Brain. 2021 Jul 1:awab251. doi: 10.1093/brain/awab251. Epub ahead of print. PMID: 34196664.
    • Zhao X, Fan Y, Vann PH, Wong JM, Sumien N, He JJ. Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging. Aging Dis. 2020 Feb 1;11(1):93-107. doi: 10.14336/AD.2019.0323. PMID: 32010484; PMCID: PMC6961778.
    • Fan, Y., Gao, X., Chen, J., Liu, Y. and He, J. J. (2016) HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway. Journal of Neuroscience 36:11362-11373. 
    • Liu, Z., and He, J. J. (2013) Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection, and Replication and Their Requirement for HCV Receptors. Journal of Virology 87:8545-8558. 
    • Henao-Mejia, J., Liu, Y., Park, I-W., Zhang, J., Sanford, J. and He, J. J. (2009) Suppression of HIV-1 Nef Translation by Sam68 Mutant-Induced Stress Granules and nef mRNA Sequestration. Molecular Cell 33:87-96.
    • Liu, Y., Liu, H., Kim, B. O., Nath, A., Li, J., Blum, J., and He, J. J. (2004) CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose Receptor. Journal of Virology 78:4121-4133.
    • Kim, B. O., Liu, Y., Xu, Z. C., Ruan, Y., Schantz, L., and He, J. J. (2003) Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline. American Journal of Pathology 162:1693-1707.
    • Liu, Y., Jones, M., Huntington, C.E., Bu, G., Laribee, N., Moir, R., Tanzi, R., Nath, A., and He J. J. (2000) Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine 6:1380-1387.

Inflammatory & Autoimmune Diseases

  • Gustavo J. Martinez
    • Tanaka K, Martinez GJ, Yan X, et al. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. Cell Rep. 2018 May 22;23(8):2318-2329. doi: 10.1016/j.celrep.2018.04.088.
    • Cao W, Kayama H, Chen ML, Delmas A, Sun A, Kim SY, Rangarajan ES, McKevitt K, Beck AP, Jackson CB, Crynen G, Oikonomopoulos A, Lacey PN, Martinez GJ, Izard T, Lorenz RG, Rodriguez-Palacios A, Cominelli F, Abreu MT, Hommes DW, Koralov SB, Takeda K, Sundrud MS. The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids. Immunity. 2017 Dec 19;47(6):1182-1196.e10. doi: 10.1016/j.immuni.2017.11.012.
    • Martinez GJ*, Hu JK, Pereira RM, Crampton JS, Togher S, Bild N, Crotty S, and Rao A. Cutting Edge: NFAT transcription factors promote the generation of follicular helper T cells in response to acute viral infection. J Immunol. 2016 Mar 1;196(5):2015-9. doi: 10.4049/jimmunol.1501841. Epub 2016 Feb 5.
  • Joseph Reynolds
    • Marks KE, Cho K, Stickling C, Reynolds JM. Toll-like receptor 2 in autoimmune inflammation. Immune Netw. 2021 Jun;21(3):e18. doi: 10.4110/in.2021.21.e18
    • Flaherty S and Reynolds JM. TLR Function in Murine CD4(+) T Lymphocytes and Their Role in Inflammation. Methods Mol Biol. 2016;1390:215-27. doi: 10.1007/978-1-4939-3335-8_14.
    • Zhang Y, Nguyen T, Tang P, Kennedy NJ, Jiao H, Zhang M, Reynolds JM, Jaeschke A, Martin-Orozco N, Chung Y, He W, Wang C, Jia W, Ge B, Davis RJ, Flavell RA, and Dong C. “Regulation of adipose tissue inflammation and insulin resistance by MAP kinase phosphatase 5”. The Journal of Biological Chemistry 2015, April 28 (online)
    • Reynolds JM, Lee YH, Shi Y, Angkasekwinai P, Nallaparaju KC, Flaherty S, Chang SH, Watarai H, Dong C. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. Immunity 2015, 42(4): 692-703.

Inflammatory & Infectious Diseases

  • Fabio Re
    • Wang J, Sahoo M, Lantier L, Warawa J, Cordero H, Deobald K, Re F.  Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18.  PLoS Pathog. 2018 May 23;14(5):e1007105. doi: 10.1371/journal.ppat.1007105. eCollection 2018 May.
    • del Barrio L., Sahoo M., Lantier L., Reynolds J.M., Ceballos-Olvera I., Re F. (2015) Production of anti-LPS IgM by B1a B cells depends on IL-1β and is protective against lung infection with Francisella tularensis LVS. PLoS Pathog 11(3): e1004706. doi:10.1371/journal.ppat.1004706
    • Sahoo, M., del Barrio, L., Miller, M.A., and Re, F. (2014) Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with Burkholderia species. PLoS Pathog. 10(8): e1004327. doi:10.1371/journal.ppat.1004327. PMID:25166912

Metabolic Disease - Obesity

Muscular Dystrophy

  • Hongkyun Kim
    • Oh KH, Kim H. Aldicarb-induced Paralysis Assay to Determine Defects in Synaptic Transmission in Caenorhabditis elegans. Bio Protoc. 2017 Jul 20;7(14). pii: e2400. doi: 10.21769/BioProtoc.2400.
    • Oh, K.H., Haney, J., Wang, X, Chuang, C.F., Richmond, J., and Kim, H (2017) ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans. eLife, 6:e24733.
    • Li, H, Kim, H, Furst, J., Raicu, D. (2016) A run-length encoding approach for path similarity analysis of C. elegans search behavior. Computational and Mathematical Methods in Medicine, 2016:3516089
    • Kim, H., and Oh, K. (2016) Protein network interacting with BK channel. Int Rev Neurobiol. 2016;128:127-61. doi: 10.1016/bs.irn.2016.03.003. Epub 2016 Mar 28.

Musculoskeletal

  • Joseph X. DiMario
    • DiMario JX. (2018) KLF10 Gene Expression Modulates Fibrosis in Dystrophic Skeletal Muscle. Am J Pathol. 188:1263-1275.
    • Hatch K, Pabon A, DiMario JX. (2017) EMX2 activates slow myosin heavy chain 2 gene expression in embryonic muscle fibers. Mech Dev. 147:8-16.
    • Cavanaugh E, DiMario JX. (2017) Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation. Gene. 617:24-31.

Reproductive health

  • Kenneth D. Beaman
    • Agrawal V, Jaiswal MK, Beaman KD, Hirsch E. Surfactant Protein (SP)-A Suppresses Preterm Delivery Induced By Live E. coli in Mice. Biol Reprod. 2018 Mar 24. doi: 10.1093/biolre/ioy074. [Epub ahead of print]
    • Beaman KD, Dambaeva S, Katara GK, Kulshrestha A, Gilman-Sachs A. The immune response in pregnancy and in cancer is active and supportive of placental and tumor cell growth not their destruction. Gynecol Oncol. 2017 Jun;145(3):476-480. doi: 10.1016/j.ygyno.2017.04.019. Epub 2017 May 3.
  • Svetlana Dambaeva
    • Dambaeva S, Bilal M, Schneiderman S, Germain A, Fernandez E, Kwak-Kim J, Beaman K,  Coulam C. Decidualization score identifies an endometrial dysregulation in samples from women with recurrent pregnancy losses and unexplained infertility. Fertility & Sterility Reports, Dec 2020, DOI:https://doi.org/10.1016/j.xfre.2020.12.004
    • Bilal MY, Katara G, Dambaeva S, Kwak-Kim J, Gilman-Sachs A, Beaman KD. Clinical molecular genetics evaluation in women with reproductive failures. Am J Reprod Immunol. 2021 Apr;85(4):e13313. doi: 10.1111/aji.13313. Epub 2020 Aug 25. PMID: 32710571.
    • Bilal MY, Dambaeva S, Brownstein D, Kwak-Kim J, Gilman-Sachs A, Beaman KD.Iodide Transporters in the Endometrium: A Potential Diagnostic Marker for Women with Recurrent Pregnancy Failures. Med Princ Pract. 2020 Apr 30. doi: 10.1159/000508309. PubMed PMID: 32353856.
    • El-Azzamy H, Dambaeva SV, Katukurundage D, Salazar Garcia MD, Skariah A, Hussein Y, Germain A, Fernandez E, Gilman-Sachs A, Beaman KD, Kwak-Kim J.  Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses.
      Am J Reprod Immunol. 2018 Oct;80(4):e13024. doi: 10.1111/aji.13024.
    • Gilman-Sachs A, Dambaeva S, Salazar Garcia MD, Hussein Y, Kwak-Kim J, Beaman K.  Inflammation induced preterm labor and birth.  J Reprod Immunol. 2018 Sep;129:53-58. doi: 10.1016/j.jri.2018.06.029.
    • Dambaeva S, Schneiderman S, Jaiswal MK, Agrawal V, Katara GK, Gilman-Sachs A, Hirsch E, Beaman KD. Interleukin 22 prevents lipopolysaccharide- induced preterm labor in mice. Biol Reprod. 2018 Mar 1;98(3):299-308. doi: 10.1093/biolre/iox182.
    • Bilal MY, Dambaeva S, Kwak-Kim J, Gilman-Sachs A, Beaman KD. A Role for Iodide and Thyroglobulin in Modulating the Function of Human Immune Cells. Front Immunol. 2017 Nov 15;8:1573. doi: 10.3389/fimmu.2017.01573. eCollection 2017.
    • Salazar Garcia MD, Mobley Y, Henson J, Davies M, Skariah A, Dambaeva S, Gilman-Sachs A, Beaman K, Lampley C, Kwak-Kim J. Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia. J Reprod Immunol. 2018 Feb;125:25-31. doi: 10.1016/j.jri.2017.10.048. Epub 2017 Nov 2.
    • Dambaeva SV, Lee DH, Sung N, Bao S, Gilman-Sachs A, Kwak-Kim J, Beaman KD. Recurrent pregnancy loss in women with killer cell immunoglobulin-like receptor KIR2DS1 is associated with an increased HLA-C2 allelic frequency. Am J Reprod Immunol. 2016 Feb;75(2):94-103
  • Alice Gilman-Sachs
    • Jaiswal MK, Agrawal V, Pamarthy S, Katara GK, Kulshrestha A, Gilman-Sachs A, Beaman KD, Hirsch E. Notch Signaling in Inflammation-Induced Preterm Labor. Sci Rep. 2015 Oct 16;5:1522.
    • Jaiswal M.K., Katara G.K., Mallers T.M., Chaouat G., Gilman-Sachs A., Beaman K.D. (2014). Vacuolar-ATPase isoform a2 regulates macrophages and cytokine profile necessary for normal spermatogenesis in testis. Journal of Leukocyte Biology. 2014 Aug;96(2):337-47.
  • Carl White

Vaccine

  • Kwang Poo Chang
    • Chang, KP, Kolli BK, New Light group (2016) New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasit Vectors. 9:396.
    • Chang, KP. (2014) Vaccination for Disease Prevention and Control: The Necessity of Renewed Emphasis and New Approaches. J Immunol Immunotech. 1: 1-4.