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Neil Bradbury, Ph.D.

Professor, Physiology and Biophysics

Chicago Medical School
Building: RLE-3.351
Phone: 847-578-8362
Research Projects
Dr. Bradbury's research interests lie in the area of regulation of membrane protein trafficking in polarized epithelia. We have used the chloride channel protein CFTR as a paradigm for the cAMP dependent regulation of apical membrane endocytic events. We are interested in the protein-protein interactions between adaptins, clathrin, and CFTR involved in the endocytic internalization of CFTR. Interest also lies in the cAMP-dependent protein kinase (PKA) regulation of CFTR channel activity and trafficking and its mediation by binding of PKA to subcellular anchor proteins (AKAPs).