Rahul Deshmukh, PhD

Assistant Professor, Pharmaceutical Sciences
College of Pharmacy
Building: IPEC
Room: 2.805
Phone: 847-578-3233

Email: Rahul.Deshmukh@rosalindfranklin.edu

Recent Publications

Deshmukh R, Blomme E. (2009) A dog is not a rat: importance of understanding species differences in drug absorption, distribution, metabolism and excretion (ADME). Vet J. 179(1):8-9.

Tu Y, Deshmukh R, Sivaneri M, Szklarz GD. (2008) The Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants. Drug Metab Dispos. 36(11):2371-80

Hom K, Deshmukh R, Furci L, Wilks A. (2007) NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria. Biomol. NMR Assignments. (1):55-56

Deshmukh R, Huang HW, Zeng Y, Furci LM, Moenne-Loccoz P, Rivera M, Wilks A. Heme Oxidation and Regioselectivity in a Chimeric Protein of the α-selective Neisserriae meningitides Heme Oxygenase (nm-HO): Replacement of the Distal Helix of nm-HO with that of the δ-selective Pseudomonas aeruginosa (pa-HO). Biochemistry. 44(42):13713-23.

Zheng Y, Deshmukh R*, Rivera M, Wilks A. (2004). Mixed Regioselectivity in the Arg-177 Mutants of Corynebacterium diphtheriae Heme Oxygenase is a Consequence of a Dynamic Equilibrium between Two Alternate Heme Seatings. Biochemistry. 43(18):5222-38 (* Shared First Authorship)

Caignan GA, Deshmukh R, Zeng Y, Huang HW, Moenne-Loccoz P, Bunce RA, Eastman MA, Wilks A, Rivera M. (2003). Magnetic resonance studies on FeIII - hydroxide as a model to mimic the hydroperoxide intermediate of heme oxygenase reaction in Pseudomonas aeruginosa heme oxygenase. J Am Chem Soc. 125(39):11842-52.

Friedman J, Lad L, Deshmukh R, Li H, Wilks A,  Poulos T. (2003). Crystal Structures of the NO- and CO-Bound Heme Oxygenase from Neisseriae meningitidis: Implications for O2 Activation. J Biol Chem. 278(36):34654-9.

Caignan GA, Deshmukh R, Wilks A, Zeng Y, Huang HW, Moenne-Loccoz P, Bunce RA, Eastman MA, Rivera M. (2002). Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme. J Am Chem Soc. 124(50):14879-92.

Ratliff M, Zhu W, Deshmukh R, Wilks A, Stojiljkovic I. (2001). Homologues of Neisseria heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa. J Bacteriol. 183:6394-403.                                                                                

Deshmukh R, Tu Y, Ericksen SS, Gannett PM,  Szklarz GD. Orientation of phenacetin and acetaminophen within the active-site of human cytochromes P450 1A1 and 1A2 - a NMR and homology modeling study. (expected submission – Summer 2011)


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