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Mirek Dundr, Ph.D.

Assistant Professor
Chicago Medical School
Room 3.212
Building: BSB
Phone: 847.578.8387
Fax: 847.578.3253

Selected Recent Publications:

Olson, MOJ and Dundr, M. (2014) Nucleolus: Structure and Function. eLS in press.

Case, AM, Sawyer, IA, Dundr, M., Hastings ML (2014) Pre-mRNA Splicing: Function and Dysfunction. Encyclopedia of Cell Biology, in press.

Dundr, M. Nucleation of nuclear bodies by RNA. (2013). Methods Mol. Biol. 1042: 351-64.

Ko, N.L., Taylor, J.M., Bellon, M., Pratt, G., Rechsteiner, M., Shevtsov, S.P., Dundr, M., Nicot, C. (2013) HTLV-I p30 Recruits the Proteasome Activator PA28g to Suppress Virus Replication. Blood 121: 791-800.

Tripathi V, Song DY, Zong X, Shevtsov SP, Hearn S, Fu X-D, Dundr M., Prasanth KV (2012) SRSF1 modulates the organization of splicing factors in nuclear speckles and regulates transcription. Mol. Biol. Cell. 23: 3694-3706.

Poh YC, Shevtsov SP, Chowdhury F, Wu DC, Na S, Dundr M.*, Wang N (2012) Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells. Nat. Commun. 3:866. doi: 10.1038/ncomms1873. *co-corresponding author.

Kamieniarz K, Izzo A, Dundr M., Tropberger P, Ozretic L, Kirfel J, Scheer E, Tropel P, Wisniewski JR, Tora L, Viville S, Buettner R, Schneider R. (2012) A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. Genes Dev. 26: 797-802.

Dundr M. (2012) Nuclear bodies: multifunctional companions of the genome. Curr Opin Cell Biol. 24: Apr 25.

Dundr, M.
(2011) Seed and grow: a two-step model for nuclear body biogenesis. J. Cell Biol. 193: 605-6.

Hergeth, S.P., Dundr, M., Tropberger, P., Zee, B.M., Garcia, B.A., Daujat, S., Schneider, R. (2011) Isoform specific phosphorylation of human linker histone H1.4 in mitosis by Aurora B kinase. J. Cell Sci. 124: 1623-8.

Liu, J., Chung, H-J., He, L., Malide D., Dundr, M., Levens, D. (2011) Synergetic action of JTV1 and FBP induces USP29 transcription to stabilize p53. EMBO J. 30: 846-58.

Shevtsov, S.P., Dundr, M. (2011) Nucleation of nuclear bodies by RNA. Nature Cell Biol. 13: 167-73.

Dundr, M.*, Misteli T. (2010). Biogenesis of nuclear bodies. The Nucleus. (Spector, D.L., Misteli, T., eds.) Cold Spring Harbor Press. *contributed equally, co-corresponding author. Cold Spring Harb. Perspect. Biol. 2:a000711.

Vogler, C., Huber, C., Waldmann, T., Braun, L., Chassignet, I., Dundr, M., Längst, G., Schneider, R. Histone H2A C-terminus regulates chromatin dynamics, remodeling and histone H1 binding and cellular stress response. PLoS Genet. 6:e1001234.

Weiss, T., Hergeth, S., Zeissler, U., Izzo, A., Tropberger, P., Zee, B.M., Dundr, M., Garcia, B.A., Daujat, S., Schneider, R. (2010) Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D. Epigenetics Chromatin. 3: 7.

Shevtsov S, Dundr M. (2009).De novo formation of subnuclear bodies on their target genes. Chromosome Res. 17: 535-6.

Kaiser TE, Intine RV, Dundr M. (2008). De novo formation of a subnuclear body. Science 322:1713-7.

Bierhoff H, Dundr M., Michels AA, Grummt I. (2008). Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol. 28: 4988-98.

Dundr M., Ospina JK, Sung MH, John S, Upender M, Ried T, Hager GL, Matera AG. (2007). Actin-dependent intranuclear repositioning of an active gene locus in vivo. J. Cell Biol. 179: 1095-103  Corresponding author

Fukumoto R, Dundr M., Nicot C, Adams A, Valeri VW, Samelson LE, Franchini G. (2007).  Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1. J. Virol. : 81: 9088-99

Gorski. S.A., Dundr, M. *, Misteli, T. (2006). The road much traveled: trafficking in the cell nucleus. Curr. Opin. Cell Biol. 18: 284-90. *contributed equally.

Stavreva, D.A., Kawasaki, M., Dundr, M., Koberna, K., Mueller, W.G., Tsujimura-Takahashi, T., Komatsu, W., Hayno, T., Raska, I., Misteli, T., Takahashi, N., McNally, J.G. (2006). Potential roles for ubiquitin and the proteasome during ribosome biogenesis.  Mol. Cell Biol. 26: 5131-45.

Ghorbel, S., Sinha-Datta, U., Dundr, M., Brown, M., Franchini, G., Nicot, C. (2006). Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60S ribosomal subunit. J. Biol. Chem. 281(48): 37150-8.

Wagner, E.J., Ospina, JK, Hu, Y., Dundr, M., Matera, A.G., Marzluff, W.F. (2006). Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA 12: 1206-18.

Chung, H.-J., Liu, J., Dundr, M., Nie, Z., Sanford, S., Levens, D. (2006). FBPs are calibrated molecular tools to adjust gene expression. Mol. Cell Biol. 26: 6584-97.

Jiao, W., Datta, J., Lin, H.-M., Dundr, M., Rane, S.G. (2006) Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export.
J. Biol Chem. 281: 38098-108.

Olson, M.O.J., Dundr, M. (2005) The moving parts of the nucleolus. Histochem. Cell Biol. 123: 203-216.

Dundr, M., Ospina J.K., Sung M.H., John S., Upender M., Ried T., Hager G.L., Matera A.G. (2007) Actin-dependent intranuclear repositioning of an active gene locus in vivo. J. Cell Biol.  179:1095-103

Fukumoto R., Dundr, M., Nicot C., Adams A., Valeri V.W., Samelson L.E., Franchini G. (2007) Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1. J. Virol.  81:9088-99.

Franchini, G., Fukumoto, R., Dundr, M. Valeri, V.W. (2005) HTLV-1 p12I and p30II proteins in viral persistence and pathogenesis. Braz. J. Infect. Dis. 9: 447-9.

Dundr, M., Misteli, T. (2004) Transcriptional complexity from dynamic interaction networks in vivo. Current Genomics. 5: 559-566.

Chen, D., Dundr, M. Wang, C., Leung, A., Lamond, A., Misteli, T., Huang, S. (2005) Condensed mitotic chromatin is accessible to the transcription machinery and chromatin structural proteins. J. Cell Biol. 168: 41-54.

Younis, I., Khair, L., Dundr, M., Lairmore, M., Franchini, G., Green, P.L. (2004) Repression of human T-cell leukemia virus type 1 and 2 replication by a novel postranscriptional regulator. J. Virol. 78: 11077-11083.

Dundr, M., Hebert, M.D., Hongzi Xu, H., Stanek, D.,  Karpova, T.S., Neugebauer, K, M.D., Matera, A.G., Misteli, T. (2004) In vivo kinetics of Cajal body components. J. Cell Biol. 164: 831-842.

Intine, R., Dundr, M., Vasssilev, A., Schwartz, E., Zhou Y., DePamphilis, M.L., Maraia, R.J. (2004) Nonphosphorylated human La accumulates at nucleolar sites involved in rRNA biogenesis and interacts with nucleolin. Mol. Cell. Biol. 24: 10894-10904.

Nicot, C, Dundr, M., Johnson, J.M., Fullen, J.R., Fukumoto, R., Misteli, T., Franchini, G. (2004) A novel post-transcriptional mechanism for retroviral latency. Nature Med. 10: 197-201.

Dundr, M., Misteli T. (2003) Gene expression dynamics. Biomed Pharmacother. 57: 180.

Cheutin, T, Misteli T, Dundr, M. (2004) Dynamics of Nucleolar Components. In The Nucleolus. M. Olson ed., Landes Bioscience. Kluwer Academic/Klenum Publ., pp. 29-40.

Parada L., Elbi C., Dundr, M. and Misteli T. (2003) Gene expression. In Essential Cell Biology: Volume 2: Cell Function (Davey J and Lord M, ed). Oxford University Press. 47-77.

Dundr, M., Hoffmann-Rohrer U., Hu Q., Grummt I., Rothblum L.I., Phair R.D. Misteli T. (2002) A kinetic framework for RNA polymerase in vivo. Science 298: 1623-1626.

Dundr, M., McNally J.G., Cohen J, Misteli T. (2002). Quantitation of GFP fusion proteins in single living cells. J. Struct Biol. 140: 92-99.

Dundr, M., Misteli T. (2003) Measuring dynamics of nuclear proteins by photobleaching. Current Protocols in Cell Biology, Unit 13.5 (1-18), Supplement 18.

Cavanaugh A., Hirschler-Laszkiewicz I., Hu Q., Dundr, M., Smink T., Misteli T., Rothblum L.I. (2002) Rrn3 phosphorylation is a regulatory switch for ribosome biogenesis: cycloheximide inhibits the phosphorylation of Rrn3 and the interaction between Rrn3 and RPA43. J. Biol. Chem. 277: 27423-27432.

Intine R.V., Dundr, M., Misteli T., Maraia R.J. (2002) Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs. Mol. Cell 9: 1113-1123.

Dundr, M. and Misteli T. (2002) Nucleolomics: An inventory of the nucleolus. Mol. Cell 9: 5-7.

Dundr, M. and Misteli T. (2001) Functional architecture in the cell nucleus. Biochem. J. 356: 297-310.

Dundr, M., Misteli T., Olson M.O.J. (2000). The dynamics of postmitotic reassembly of the nucleolus. J. Cell Biol. 150: 433-446.

Olson M.O.J, Dundr, M., Szebeni A. (2000). The nucleolus: an old factory with unexpected capabilities. Trends Cell Biol. 10: 189-196.

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