Biography

Dr. Dutta received his M.Sc. from University of Calcutta, India in 2001, and his Ph.D. degree in Microbiology and Immunology from Rosalind Franklin University of Medicine and Science, USA, in 2007. Dr. Dutta's postdoctoral experience includes positions as Postdoctoral Research Associate and then as Senior Research Associate, first in the Leishmania biology laboratory and then with the H.M. Bligh Cancer Research Group at the Rosalind Franklin University of Medicine, North Chicago, USA, between 2008-2012. He was appointed as Research Assistant Professor in the H.M. Bligh Cancer Research Group at the RFUMS in July 2012.

Research Interests
The long-term goal is to understand the different mechanisms employed by cancer cells to manipulate their immediate microenvironment and create a “niche” that are favorable for their survival, tumor growth and metastasis.

Currently under study are; (1) the different roles of pro-angiogenic molecule – angiogenin in cell survival and metastasis of breast cancer and melanoma and (2) immune-modulatory properties of exosomes released by different types and stages of malignant melanomas.

Publications

1.      Dutta S, Ray D, Kolli BK, Chang KP. Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro. Antimicrobial Agents Chemotherapy. 2005; 49:4474-4484.

 2.      Waki K, Dutta S, Ray D, Kolli BK, Akman L, Kawazu S, Lin CP, Chang KP. Transmembrane molecules for phylogenetic analyses of pathogenic protists: Leishmania-specific informative sites in hydrophilic loops of trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase. Eukaryotic Cell. 2007; 6:198-210.

 3.      Dutta S, Furuyama K, Sassa S, Chang KP. Leishmania spp: Delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway. Experiential Parasitology. 2008.118: 629-636.

 4.      Dutta S, Kolli BK, Tang A, Sassa S, Chang KP. Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin. Eukaryotic Cell. 2008; 7:1146-1157.

 5.      Kumari S, Samant M, Khare P, Misra P, Dutta S, Kolli BK, Sharma S, Chang KP, Dube A. Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis. European Journal of Immunology. 2009; 1:178-191.

 6.      Ruben EVM, Munoz DL, Robleodo S, Kolli BK, Dutta S, Chang KP, Muskus C. Transfection of Leishmania panamensis to express green fluorescent protein for screening of antileishmaial drugs. Experimental Parasitology. 2009; 122:134-139.

 7.      *Dutta S, Ongarora BG, Li H, Vicente MGH, Kolli BK, Chang KP. Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photodynamic medicine. PLoS ONE 6(6). 2011; e20786.

 8.      *Dutta S, Waki K and Chang KP. Synergistic activities of two different photosensitizers toward complete photolysis of Leishmania in vitro and in vivo. Photobiology and photochemistry. 2012.

 9.      Dutta S, Chang C, Kolli BK, Sassa S, Yousef M, Showe M, Showe L, Chang KP. Delta-aminolevulinate-induced host-parasite disparity in porphyrin accumulation for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: A potentially novel platform for vaccine delivery. Eukaryotic Cell. 2012.

*: Corresponding author