Dr. Dutta received his M.Sc. from University of Calcutta, India in 2001, and his Ph.D. degree in Microbiology and Immunology from Rosalind Franklin University of Medicine and Science, USA, in 2007. Dr. Dutta's postdoctoral experience includes positions as Postdoctoral Research Associate and then as Senior Research Associate, first in the Leishmania biology laboratory and then with the H.M. Bligh Cancer Research Group at the Rosalind Franklin University of Medicine, North Chicago, USA, between 2008-2012. He was appointed as Research Assistant Professor in the H.M. Bligh Cancer Research Group at the RFUMS in July 2012 and he is under the mentorship of Dr. Bala Chandran.
The long-term goal is to understand the different mechanisms employed by cancer cells to manipulate their immediate microenvironment and create a “niche” that are favorable for their survival, tumor growth and metastasis. Currently under study are; (1) the different roles of pro-angiogenic molecule – angiogenin in cell survival and metastasis of breast cancer and melanoma and (2) immune -modulatory properties of exosomes in context of infectious diseases and cancer.
1. Vahedi S, Chueh FY, Dutta S, Chandran B, Yu CL. Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells. Oncol Rep. 2015 May 19. doi:10.3892/or.2015.3990.
2. Gjyshi O, Roy A, Dutta S, Veettil MV, Dutta D, Chandran B. Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 andHost Protein KAP1 to Mediate Global Lytic Gene Repression. J Virol. 2015 May 20. pii: JVI.00895-15.
3. Johnson KE, Bottero V, Flaherty S, Dutta S, Singh VV, Chandran B. IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications. PLoS Pathog. 2014 10:e1004503.
4. Gjyshi O, Bottero V, Veettil MV, Dutta S, Singh VV, Chikoti L, Chandran B. Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 during De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection. PLoS Pathog. 2014 10:e1004460. 4. Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma-Walia N, Dutta S, Chandran B. Glutamate Secretion and Metabotropic Glutamate Receptor 1 Expression during Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Cell Proliferation. PLoS Pathog. 2014 10:e1004389.
5. Bandyopadhyay C, Veettil MV, Dutta S, Chandran B. p130Cas Scaffolds the Signalosome To Direct Adaptor-Effector Cross Talk during Kaposi's Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells. J Virol. 2014 88:13858-78.
6. Dutta S*, Warshall C, Bandyopadhyay C, Dutta D, Chandran B. Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells. PLoS One. 2014 May 15;9(5):e97580.
7. Dutta S*, Bandyopadhyay C, Bottero V, Veettil MV, Wilson L, Pins MR, Johnson KE, Warshall C, Chandran B. Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration. Mol Oncol. 2014 Jan 4. pii: S1574-7891(13)00189-0. doi:10.1016/j.molonc.2013.12.017. [Epub ahead of print]
8. Singh VV, Dutta D, Ansari MA, Dutta S, Chandran B. Kaposi's Sarcoma-Associated Herpesvirus Induces the ATM and H2AX DNA Damage Response Early during De Novo Infection of Primary Endothelial Cells, Which Play Roles in Latency Establishment. J Virol. 2014 Mar;88(5):2821-34.
9. Bottero V, Sadagopan S, Johnson KE, Dutta S, Veettil MV, Chandran B. Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation. J Virol. 2013 Nov;87(21):11806-20.
10. Ansari MA, Singh VV, Dutta S, Valiya Veettil M, Dutta D, Chikoti L, Lu J,Everly D, Chandran B. Constitutive Interferon-Inducible Protein 16-Inflammasome Activation During Epstein-Barr Virus Latency I, II and III in B and Epithelial Cells. J Virol. 2013 May 29. [Epub ahead of print] PubMed PMID: 23720728.
11. Singh VV, Kerur N, Bottero V, Dutta S, Chakraborty S, Ansari MA, Paudel N,Chikoti L, Chandran B. Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes. J Virol. 2013. 8:4417-31.
12. Kaur J, Dutta S, Chang KP, Singh N. A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol. J Antimicrob Chemother. 2013. 5:1071-80.
13. Dutta S, Chang C, Kolli BK, Sassa S, Yousef M, Showe M, Showe L, Chang KP. Delta-aminolevulinate-induced host-parasite disparity in porphyrin accumulation for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: A potentially novel platform for vaccine delivery. Eukaryotic Cell. 2012.
14. *Dutta S, Waki K and Chang KP. Synergistic activities of two different photosensitizers toward complete photolysis of Leishmania in vitro and in vivo. Photobiology and photochemistry. 2012.
15. *Dutta S, Ongarora BG, Li H, Vicente MGH, Kolli BK, Chang KP. Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photodynamic medicine. PLoS ONE 6(6). 2011; e20786.
16. Ruben EVM, Munoz DL, Robleodo S, Kolli BK, Dutta S, Chang KP, Muskus C. Transfection of Leishmania panamensis to express green fluorescent protein for screening of antileishmaial drugs. Experimental Parasitology. 2009; 122:134-139.
17. Kumari S, Samant M, Khare P, Misra P, Dutta S, Kolli BK, Sharma S, Chang KP, Dube A. Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis. European Journal of Immunology. 2009; 1:178-191.
18. Dutta S, Kolli BK, Tang A, Sassa S, Chang KP. Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin. Eukaryotic Cell. 2008; 7:1146-1157.
19. Dutta S, Furuyama K, Sassa S, Chang KP. Leishmania spp: Delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway. Experiential Parasitology. 2008.118: 629-636.
20. Waki K, Dutta S, Ray D, Kolli BK, Akman L, Kawazu S, Lin CP, Chang KP. Transmembrane molecules for phylogenetic analyses of pathogenic protists:Leishmania-specific informative sites in hydrophilic loops of trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase. Eukaryotic Cell. 2007; 6:198-210.
21. Dutta S, Ray D, Kolli BK, Chang KP. Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro. Antimicrobial Agents Chemotherapy. 2005; 49:4474-4484.
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