David H. T. Harrison, PhD

Vice-Chair, Pharmaceutical Sciences
Professor, Pharmaceutical Sciences
College of Pharmacy
Building: HSB
Room: 2.614
Phone: 847-578-8710
Email: David.Harrison@rosalindfranklin.edu



Recent Publications

Aluvila S, Sun J, Harrison DH, Walters DE, Kaplan RS (2010) “Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor” Mol Pharmacol. 77:26-34

Remani S, Sun J, Kotaria R, Mayor JA, Brownlee JM, Harrison DH, Walters DE, Kaplan RS (2008) “The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate” J Bioenerg Biomembr. 40: 577-585

June Brownlee, Panqing He, Graham R. Moran, and David H. T. Harrison (2008) “Two Roads Diverged: The Structure of Hydroxymandelate Synthase from Amycolatopsis orientalis in Complex with 4-Hydroxymandelate” Biochemistry 47: 2002-2013

Brownlee, J.M., Calrson, E., Milne, A.C., Pape, E., and Harrison, D. H. T. (2006) “Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes” Bioorganic Chemistry 34:424-444.

Bohren, K. M., Messmore, J., Milne, A., Gabbay, K. H., and Harrison, D. H. T. (2005) “Hinges and Latches: The Structure of Human Apo Aldose Reductase and Its Relationship to the Enzyme Mechanism” Biochemica & Biophysica Acta 1748:201-212.

Park, M., Lin, L., Thomas, S., Braymer, H. D., Smith, P. M., Harrison, D. H., and York, D. A. (2004) “The F1-ATPase beta-subunit is the putative enterostatin receptor” Peptides. 25(12):2127-33.

Theisen M. J., Misra I., Saadat D., Campobasso N., Miziorko H. M. and Harrison D. H. T. (2004) “3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in ‘real-time’” Proceedings of the National Academe of Sciences 101:16442-16447

Brownlee, J. M., Johnson-Winters, K., Harrison, D. H. T., and Moran, G. R. (2004) “Structure of the Ferrous Form of (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis in Complex with the Therapeutic Herbicide, NTBC” Biochemistry (Accelerated Publication) 43(21):6370-6377.

Marks, G. T., Susler, M., and Harrison D. H. T. (2004) “Mutagenic Studies on Histidine 98 of Methylglyoxal Synthase: Effects on Mechanism and Conformational Change” Biochemistry 43(13):3802-3813.

Zhang, X., Harrison D. H. T., Cui Q. (2002) “The functional specificities of methylglyoxal synthase (MGS) and triosephosphate isomerase (TIM) are not due to stereoelectronic effects: A combined QM/MM analysis” Journal of the American Chemical Society 124(50):14871-14878

Marks, G., Harris, T. K., Massiah, M. A., Mildvan, A. S., and Harrison, D. H. T. (2001) “Mechanistic Implications of Methylglyoxal Synthase Complexed with Phosphoglycolohydroxamic Acid as Observed by X-Ray Crystallography and NMR Spectroscopy” Biochemistry 40: 6805-6818

Saadat, D. and Harrison D. H. T. (2000) “Mirroring Perfection: The Structure of Methylglyoxal Synthase Complexed With the Competitive Inhibitor 2-Phosphoglyocolate.” Biochemistry 39: 2950-2960.

Kung, G., Runquist, J. A., Miziorko H. M., and Harrison, D. H. T. (1999) “The Identification of the Allosteric Regulatory Site in Bacterial Phosphoribulokinase” Biochemistry 38:15157-15165.

Runquist, J. A., Harrison, D. H. T., Miziorko H. M. (1999) “R. Sphaeroides Phosphoribulokinase: Identification of Lysine-165 as a Catalytic Residue and Evaluation of the Contributions of Invariant Basic Amino Acids to Ribulose 5-Phosphate Binding” Biochemistry 38:13999-14005.

Saadat, D. and Harrison D. H. T. (1999) “The Crystal Structure of Methylglyoxal Synthase from Escherichia coli” Structure with Folding & Design 7:309-317.

Life in Discovery
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