Michelle L. Hastings, Ph.D.

Associate Professor
Chicago Medical School
Room 3.224
Building: BSB
Phone: 847.578.8517
Fax: 847.578.3253
michelle.hastings@rosalindfranklin.edu
Lab website: http://hastingslab.com
Publications
  1. Havens, MA, Reich, AA, Duelli, DM, Hastings, ML. 2012. Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res. (in press).

  2. Kim, DJ, Linnstaedt, S, Palma, J, Park, JC, Ntrivalas, E, Kwak-Kim, JYH, Gilman-Sachs, A, Beaman, K, Hastings, ML, Martin, JN, and Duelli, DM. 2012. Plasma components affect accuracy of circulating cancer-related microRNA quantitation. J. Mol. Diagn. 14: 71-80.

  3. Vorlova, S, Rocco, G, LeFave, CV, Jodelka, FM, Hastings, ML, Henke, E, and Cartegni, L. 2011. Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation. Mol. Cell. 43: 927-939.

  4. Bruno, A, Huang, J, Bennett, DA, Marr, R, Hastings, ML, Stutzmann, GE. 2011. Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer’s disease. Neurobiol. Aging, in press.

  5. Pigati, L, Yaddanapudi, S, Iyengar, R, Kim, DJ, Hearn, S, Danforth, D, Hastings, ML, Duelli, DM. 2010. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One. http://dx.plos.org/10.1371/journal.pone.0013515.

  6. Jodelka, FM, Ebert, AD, Duelli, DM, Hastings, ML. 2010. A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2. Hum Mol Genet, 19: 4906-4917.

  7. Salato, VK, Rediske, NW, Zhang, C, Hastings, ML, Munroe, SH. 2010. An exon splicing enhancer within a bidirectional coding sequence regulates alternative splicing of an antisense mRNA. RNA Biology, 7: 179-90.

  8. Hastings, ML, Berniac, J, Liu, YH, Abato, P, Jodelka, FM, Barthel, L, Kumar, S, Dudley, C, Nelson, M, Larson, K, Edmonds, J, Bowser, T, Draper, M, Higgins, P, Krainer, AR. (2009) Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Science Translational Medicine, 1: 5ra12.

  9. Hastings, ML, Sachidanandam, R. 2008. Evolutionary conservation of splice sites. In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0020782.

  10. Martins de Araujo, M, Bonnal, S, Hastings, ML, Krainer, AR, Valcarcel, J. 2009. Differential 3’ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA, 15: 515-23.

  11. Zhang, C, Hastings, ML, Krainer, AR, Zhang, MQ. 2007. Dual-specificity splice sites function alternatively as 5’ and 3’ splice sites. Proc Natl Acad Sci USA, 104: 15028-33.

  12. Allemand, E, Hastings, ML, Murray, MV, Myers, MP, Krainer, AR. 2007. Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid binding protein YB-1. Nature Struct Biol, 14: 630-8.

  13. Hastings, ML, Allemand, E, Duelli, DM, Myers, MP, Krainer, AR. 2007. Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65). PLoS ONE, 2: e538.

  14. Cartegni, L, Hastings ML, Calarco, JA, de Stanchina, Krainer, AR. 2006. Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet, 78: 63-77.

  15. Sheth, N, Roca, X, Hastings, ML, Roeder, T, Krainer, AR, Sachidanandam, R. 2006. Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Res, 34: 3955-67.

  16. Hastings, ML, Resta, N, Traum, D, Stella, A, Guanti, G, Krainer, AR. 2005. An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. Nat Struct Mol Biol, 12: 54-9.

  17. Hastings, ML, Krainer, AR. 2001. Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol, 13: 302-9.

  18. Hastings, ML, Wilson, CM, Munroe, SH. 2001. A purine-rich intronic element enhances alternative splicing of thyroid hormone receptor mRNA. RNA, 7: 859-74.

  19. Hastings, ML, Krainer, AR. 2001. Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA, 7: 471-82.

  20. Hastings, ML, Ingle, HA, Lazar, MA, Munroe, SH. 2000. Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA. J Biol Chem, 275: 11507-13.

  21. Hastings, ML, Milcarek, C, Martincic, K, Peterson, ML, Munroe, SH. 1997. Expression of the thyroid hormone receptor gene, erbAalpha, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels. Nucleic Acids Res. 25: 4296-300.

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