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Kyoung Joon Oh, Ph.D.

Associate Professor
Chicago Medical School
Biochemistry and Molecular Biology
Room: 3.136
Building: BSB
Phone: 847.578.8649
Fax: 847.578.3240

For e-Print (PDF file) contact Kyoung Joon Oh

Kim, J.W., Yang. Y.S., Song. S.S., Na. J.-H, Oh. K.J., Jeong. C.H., Yu. Y.G., Shin, Y.K. 2014. Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release Biophys. J. 107(7):1601-1608. (featured in New and Notable by Daniel A. Linseman in Biophysical Journal, Oct. 2014, volume 107, pp1491-1492)[Biophysical Journal]

Song, S.S., Lee, W.K., Aluvila, S., Oh, K.J., and Yu, Y.G. 2014. Identification of inhibitors against BAK pore formation using an improved in vitro system. Bull. Korean Chem. Soc. 35(2):419-424.[Korean Chem. Soc.]

Aluvila, S., Mandal, T., Hustedt, E., Fajer, P., Choe, J.Y., and Oh, K.J. 2014. Organization of the mitochondrial apoptotic BAK pore: OLIGOMERIZATION OF THE BAK HOMODIMERS. J. Biol. Chem. 289:2537-2551 (Epub 2013 Dec 11).[medline] {Featured as one of the Key Scientific Articles in the Global Medical Discovery in April 2014) [Global Medical Discovery]

Chen, D.Y., Lee, Y., Van Tine, B.A., Searleman, A.C., Westergard, T.D., Liu, H., Tu. H.C., Takeda, S., Dong, Y., Piwnica-Worms, D.R., Oh, K.J., Korsmeyer, S.J., Hermone, A., Gussio, R., Shoemaker, R.H., Cheng, E.H., and Hsieh, J.J. 2012.  A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res. 72(3):736-746 (Epub 2011 Dec 13).[NIH]

Oh, K.J., Singh, P., Lee, K., Foss, K., Lee, S., Park, M., Lee, S., Aluvila, S., Park, M., Singh, P., Kim, R.-S., Symersky, J. and Walters, D.E. 2010. Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers J. Biol. Chem. 285: 28924-28937. [medline]

Mayor, J.A., Sun, J., Kotaria, R., Walters, D. E., Oh, K.J., and Kaplan, R.S. 2010. Probing the Effect of Transport Inhibitors on the Conformation of the Mitochondrial Citrate Transport Protein via a Site-Directed Spin Labeling Approach. J. Bioenerg. Biomembr. 42: 99-109. [medline]

Martinez-Caballero, S., Dejean, L.M., Kinnally, M.S., Oh, K.J., Mannella, C.A., Kinnally, K.W. 2009. Assembly of the mitochondrial apoptosis-induced channel, MAC. J. Biol. Chem. 284: 12235 - 12245. [medline

Sun, Z-Y J., Oh, K.J., Kim, M., Yu, J., Brusic, V., Song, L., Qiao, Z., Wang, J-H., Wagner, G., Reinherz, E.L.  2008. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity 28:52-63.[medline]

Walensky, L.D., Pitter, K., Morash, J., Oh, K.J., Barbuto, S., Fisher, J., Smith, E., Verdine, G.L., Korsmeyer, S.J. 2006. A stapled BID BH3 helix directly binds and activates BAX. Molecular Cell 24:199-210. [medline]

Oh, K.J., Barbuto, S., Pitter, K., Morash, J., Walensky, L.D., Korsmeyer, S.J. 2006. A membrane-targeted BID BH3 peptide is sufficient for high potency activation of BAX in vitro. J. Biol. Chem. 281: 36999-37008. [medline]

Oh, K.J., Barbuto, S., Meyer, N., Korsmeyer, S.J. 2005. Conformational changes in BID, a pro-apoptotic BCL-2 family member, in membranes:  A site-directed spin labeling study.  J. Biol. Chem. 280: 753-767. [medline]

Altenbach. C., Oh, K.J., Trabanino, R.J., Hideg, K., Hubbell, W.L. 2001. Estimation of inter-residue distances in spin labeled proteins at physiological temperatures: experimental strategies and practical limitations.  Biochemistry 25: 15471-15482. [medline]

Zha, J., Weiler, S., Oh, K.J., Wei, M., and Korsmeyer, S. 2000. Post-translational myristoylation of BID facilitates its targeting to mitochondria and enhances its pro-apoptotic activity. Science 290: 1761-1765. [medline]

Korsmeyer, S.J., Wei, M.C., Saito, M., Weiler, S., Oh, K.J., and Schlesinger, P.H. 2000.  Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7(12): 1166-1173. [medline]

Langen, R., Oh, K.J., Cascio, D., Hubbell, W.L. 2000. Crystal structures of spin labeled T4 lysozyme mutants: Implications for the interpretation of EPR spectra in terms of structure. Biochemistry 39: 8396-8405. [medline]

Finkelstein, A., Oh, K.J., Senzel, L., Gordon, M., Blaustein, R.O., and Collier, R.J. 2000.  The diphtheria toxin channel-forming T-domain translocates its own NH2-terminal region and the catalytic domain across planar phospholipid bilayers. Int. J. Med. Microbiol. 290: 435-440. [medline]

Senzel, L., Gordon, M., Blaustein, R.O., Oh, K.J., Collier, R.J., and Finkelstein, A. 2000. Topology of Diptheria toxin’s T-domain in the open channel state. J. Gen. Physiol. 115: 421-434. [medline]

Oh, K.J., Altenbach, C., Collier, R.J., and Hubbell, W.L. 2000. Site-directed spin-labeling: Applications to Diptheria toxin. In: Methods in Molecular Biology: Bacterial Toxins Methods and Protocols. Ed. O Holst. Humana Press, vol. 145, pp. 147-169. [medline]

Oh, K.J., Zhan, H., Cui, C., Altenbach, C., Hubbell, W.L., and Collier, R.J. 1999. Conformation of the Diphtheria toxin T-domain in membranes: A site-directed spin-labeling study of the TH8 helix and TL5 loop. Biochemistry 38: 10336-10343. [medline]

Oh, K.J., Senzel, L., Collier, R.J., and Finkelstein, A. 1999. Translocation of the catalytic domain of Diphtheria toxin across planar phospholipid bilayers by its own T-domain. Proc. Natl. Acad. Sci.  USA. 96; 8467-8470. [medline]

Huynh, P.D., Cui, C., Zhan, H., Oh, K.J., Collier, R.J., and Finkelstein, A. 1997.  Probing the structure of the Diphtheria toxin Channel.  Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives. J. Gen. Physiol. 110: 229-242. [medline]

Mchaourab, H.S., Oh, K.J.,  Fang, C.J., and Hubbell, W.L. 1997.  The conformation of T4 Lysozyme in solution.  Hinge bending motion and the substrate-induced conformational transition studied by site-directed spin labeling. Biochemistry 36: 307-316. [medline]

Oh, K.J., Zhan, H., Cui, C., Hideg, K., Collier, R.J., and Hubbell, W.L. 1996. Organization of Diphtheria toxin T domain in bilayers: A site-directed spin labeling study. Science 273:810-812. [medline]

Zhan, H., Oh, K.J., Shin, Y.-K., Hubbell, W.L., and Collier, R.J. 1995.  Interaction of the isolated transmembrane domain of Diphtheria toxin with membranes. Biochemistry 34: 4856-4863. [medline]

Oh, K.J., Choi, S.J., and Yang, C.H. 1987.  Molecular cloning of hydrogenase gene in E. coli. Korean Biochem. J. 20(2): 129-136.

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