Enter Title

Kyoung Joon Oh, Ph.D.

Assistant Professor
Chicago Medical School
Biochemistry and Molecular Biology
Room: 3.136
Building: BSB
Phone: 847.578.8649
Fax: 847.578.3240

For e-Print (PDF file) contact Kyoung Joon Oh

Song, S.S., Lee, W.K., Aluvila, S., Oh, K.J., and Yu, Y.G. 2014. Identification of inhibitors against BAK pore formation using an improved in vitro system. Bull. Korean Chem. Soc. 35(2):419-424.[Link]

Aluvila, S., Mandal, T., Hustedt, E., Fajer, P., Choe, J.Y., and Oh, K.J. 2014. Organization of the mitochondrial apoptotic BAK pore: OLIGOMERIZATION OF THE BAK HOMODIMERS. J. Biol. Chem. 289:2537-2551 (Epub 2013 Dec 11).[medline] {Featured as one of the Key Scientific Articles in the Global Medical Discovery in April 2014) [Global Medical Discovery]

Chen, D.Y., Lee, Y., Van Tine, B.A., Searleman, A.C., Westergard, T.D., Liu, H., Tu. H.C., Takeda, S., Dong, Y., Piwnica-Worms, D.R., Oh, K.J., Korsmeyer, S.J., Hermone, A., Gussio, R., Shoemaker, R.H., Cheng, E.H., and Hsieh, J.J. 2012.  A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res. 72(3):736-746 (Epub 2011 Dec 13).[NIH]

Oh, K.J., Singh, P., Lee, K., Foss, K., Lee, S., Park, M., Lee, S., Aluvila, S., Park, M., Singh, P., Kim, R.-S., Symersky, J. and Walters, D.E. 2010. Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers J. Biol. Chem. 285: 28924-28937. [medline]

Mayor, J.A., Sun, J., Kotaria, R., Walters, D. E., Oh, K.J., and Kaplan, R.S. 2010. Probing the Effect of Transport Inhibitors on the Conformation of the Mitochondrial Citrate Transport Protein via a Site-Directed Spin Labeling Approach. J. Bioenerg. Biomembr. 42: 99-109. [medline]

Martinez-Caballero, S., Dejean, L.M., Kinnally, M.S., Oh, K.J., Mannella, C.A., Kinnally, K.W. 2009. Assembly of the mitochondrial apoptosis-induced channel, MAC. J. Biol. Chem. 284: 12235 - 12245. [medline

Sun, Z-Y J., Oh, K.J., Kim, M., Yu, J., Brusic, V., Song, L., Qiao, Z., Wang, J-H., Wagner, G., Reinherz, E.L.  2008. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity 28:52-63.[medline]

Walensky, L.D., Pitter, K., Morash, J., Oh, K.J., Barbuto, S., Fisher, J., Smith, E., Verdine, G.L., Korsmeyer, S.J. 2006. A stapled BID BH3 helix directly binds and activates BAX. Molecular Cell 24:199-210. [medline]

Oh, K.J., Barbuto, S., Pitter, K., Morash, J., Walensky, L.D., Korsmeyer, S.J. 2006. A membrane-targeted BID BH3 peptide is sufficient for high potency activation of BAX in vitro. J. Biol. Chem. 281: 36999-37008. [medline]

Oh, K.J., Barbuto, S., Meyer, N., Korsmeyer, S.J. 2005. Conformational changes in BID, a pro-apoptotic BCL-2 family member, in membranes:  A site-directed spin labeling study.  J. Biol. Chem. 280: 753-767. [medline]

Altenbach. C., Oh, K.J., Trabanino, R.J., Hideg, K., Hubbell, W.L. 2001. Estimation of inter-residue distances in spin labeled proteins at physiological temperatures: experimental strategies and practical limitations.  Biochemistry 25: 15471-15482. [medline]

Zha, J., Weiler, S., Oh, K.J., Wei, M., and Korsmeyer, S. 2000. Post-translational myristoylation of BID facilitates its targeting to mitochondria and enhances its pro-apoptotic activity. Science 290: 1761-1765. [medline]

Korsmeyer, S.J., Wei, M.C., Saito, M., Weiler, S., Oh, K.J., and Schlesinger, P.H. 2000.  Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7(12): 1166-1173. [medline]

Langen, R., Oh, K.J., Cascio, D., Hubbell, W.L. 2000. Crystal structures of spin labeled T4 lysozyme mutants: Implications for the interpretation of EPR spectra in terms of structure. Biochemistry 39: 8396-8405. [medline]

Finkelstein, A., Oh, K.J., Senzel, L., Gordon, M., Blaustein, R.O., and Collier, R.J. 2000.  The diphtheria toxin channel-forming T-domain translocates its own NH2-terminal region and the catalytic domain across planar phospholipid bilayers. Int. J. Med. Microbiol. 290: 435-440. [medline]

Senzel, L., Gordon, M., Blaustein, R.O., Oh, K.J., Collier, R.J., and Finkelstein, A. 2000. Topology of Diptheria toxin’s T-domain in the open channel state. J. Gen. Physiol. 115: 421-434. [medline]

Oh, K.J., Altenbach, C., Collier, R.J., and Hubbell, W.L. 2000. Site-directed spin-labeling: Applications to Diptheria toxin. In: Methods in Molecular Biology: Bacterial Toxins Methods and Protocols. Ed. O Holst. Humana Press, vol. 145, pp. 147-169. [medline]

Oh, K.J., Zhan, H., Cui, C., Altenbach, C., Hubbell, W.L., and Collier, R.J. 1999. Conformation of the Diphtheria toxin T-domain in membranes: A site-directed spin-labeling study of the TH8 helix and TL5 loop. Biochemistry 38: 10336-10343. [medline]

Oh, K.J., Senzel, L., Collier, R.J., and Finkelstein, A. 1999. Translocation of the catalytic domain of Diphtheria toxin across planar phospholipid bilayers by its own T-domain. Proc. Natl. Acad. Sci.  USA. 96; 8467-8470. [medline]

Huynh, P.D., Cui, C., Zhan, H., Oh, K.J., Collier, R.J., and Finkelstein, A. 1997.  Probing the structure of the Diphtheria toxin Channel.  Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives. J. Gen. Physiol. 110: 229-242. [medline]

Mchaourab, H.S., Oh, K.J.,  Fang, C.J., and Hubbell, W.L. 1997.  The conformation of T4 Lysozyme in solution.  Hinge bending motion and the substrate-induced conformational transition studied by site-directed spin labeling. Biochemistry 36: 307-316. [medline]

Oh, K.J., Zhan, H., Cui, C., Hideg, K., Collier, R.J., and Hubbell, W.L. 1996. Organization of Diphtheria toxin T domain in bilayers: A site-directed spin labeling study. Science 273:810-812. [medline]

Zhan, H., Oh, K.J., Shin, Y.-K., Hubbell, W.L., and Collier, R.J. 1995.  Interaction of the isolated transmembrane domain of Diphtheria toxin with membranes. Biochemistry 34: 4856-4863. [medline]

Oh, K.J., Choi, S.J., and Yang, C.H. 1987.  Molecular cloning of hydrogenase gene in E. coli. Korean Biochem. J. 20(2): 129-136.

Life in Discovery
Important Links