Blood-Brain Barrier Physiology, Pathophysiology of Stroke,
Renal Pathophysiology, Treatment for Diabetic Nephropathy
Current studies in our laboratory focus on: 1) functional properties of the blood-brain barrier, and prevention of injury to the blood-brain barrier associated with ischemic stroke; and 2) renal pathophysiology, and treatment and prevention of renal fibrosis associated with diabetic nephropathy.
The blood-brain barrier includes cerebral capillary endothelial cells that are sensitive to reperfusion injury associated with delayed thrombolysis following ischemic stroke. This can result in cerebral bleeding termed “hemorrhagic transformation”, culminating in death. We have been studying the cellular mechanisms responsible for blood-brain barrier injury and hemorrhagic transformation. Potential therapeutics for treatment of stroke, and protection of the cerebral vasculature under conditions of stroke, have been identified and tested.
Renal fibrosis associated with diabetes mellitus can contribute to chronic renal failure. We have been studying the cellular and molecular events responsible for renal fibrosis and diabetic nephropathy, including the design and development of drugs for treatment of these conditions.