Articles published pertaining to current research program on the underlying mechanisms of Metabolic Memory in Diabetes that began in 2008.
Articles Published or In Press:
Ansgar Olsen, Michael P. Sarras, Jr., and Robert Intine. Impaired limb regeneration in a Zebrafish model of Diabetes. J. Wound Healing and Tissue Regeneration. 2010, 18(5):532-42.
Ansgar S. Olsen, Michael P. Sarras Jr, Alexey Leontovich, and Robert V. Intine. The heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression. Diabetes. 2012, 61(2),485-91.
Robert V. Intine & Michael P. Sarras Jr. Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms. Curr. Diab. Rep. 12 (5):551-9, 2012.
Robert V. Intine, Ansgar S. Olsen, and Michel P. Sarras Jr. A zebrafish model of diabetes mellitus and metabolic memory. JOVE, 2013, 72 (e50232).
Michael. P. Sarras Jr.*, Alexey. A. Leontovich*, Ansgar. S. Olsen, and Robert. V. Intine. (*Co-first authors) Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. J. Wound Healing and Tissue Regeneration. 2013, 21(2), 320-328.
Michael P. Sarras Jr. and Robert V Intine. Use of Zebrafish as a Disease Model Provides a Unique Window For Understanding the Molecular Basis of Diabetic Metabolic Memory. iConcept Press, 2013.
Pisano*, G., Mason*, S.M., Dhliway, N., Intine, R.V., Sarras, M.P. Jr. (*Co-first authors) An Assay for Lateral Line Regeneration in Adult Zebrafish. JOVE, 2014 (In press.).
Dhliwayo, Nyembezi, Sarras Jr., Michael, Mason, Samantha, and Intine, Robert; Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Diabetes (In Press).
Articles Submitted or In Preparation:
Alexey. A. Leontovich*, Michael P. Sarras Jr.*, and Robert V. Intine. (*Co-first authors) Methylated DNA Changes in the Diabetic and Metabolic Memory States are Associated with DNA Replication and DNA Metabolism Functional Groups whose Genes have Altered Expression following the onset of Hyperglycemia. (In Preparation)
Michael P. Sarras Jr., Samantha Mason, Geoffrey McAllister, and Robert V. Intine. Wound-induced angiogenesis is impaired in the diabetic and metabolic memory states of a Zebrafish model of Type I Diabetes mellitus. (In Preparation)
Alexey. A. Leontovich, Robert V. Intine, and Michael P. Sarras Jr. Analysis of the Diabetic and Metabolic Memory States of a Zebrafish Model of Type I Diabetes. Part I: Global Genomic Analysis of DNA Methylation Patterns within Genes Affected by Hyperglycemia. (In Preparation)
Michael P. Sarras Jr., Alexey A. Leontovich*, and Robert V. Intine. (*Co-first authors) Analysis of the Diabetic and Metabolic Memory States of a Zebrafish Model of Type I Diabetes. Part II: Altered DNA Methylation Patterns within Kidney, Skin, Retina and Limb Genes Affected by Hyperglycemia. (In Preparation)