Mohanan Valiya Veettil, Ph.D

Research Assistant Professor
Room 2.419
Phone: (847) 578 8700x7716
Biography

Dr. Veettil received his Ph.D in Biotechnology from Cochin University of Science and Technology, Kerala, India in 2004. He worked as a postdoctoral fellow in the Department of Microbiology, Molecular Genetics and Immunology at University of Kansas Medical Center from 2004-2005. He joined the Rosalind Franklin University of Medicine and Science in July, 2005 as a Postdoctoral Research Associate. He was appointed as Research Assistant Professor in August 2011 under the mentorship of Dr. Bala Chandran.

RESEARCH

KSHV or human herpesvirus-8 (HHV-8) is one of the most recently discovered herpes virus. KSHV causes Kaposi's sarcoma (KS), primary effusion lymphoma and multicentric Castleman’s disease in immunosuppressed AIDS patients. Our previous studies have shown that viral glycoproteins, cell surface receptors and intracellular signaling pathways are essential components required for the entry of the virus. We also focus on the co-ordination of the various cell surface receptors and signaling machineries in long term KSHV infected endothelial cells to understand how the cell surface receptors and signaling machineries contribute to the pathogenesis of KS. We are using various biochemical and molecular biological approaches to study the abnormal receptor expression in virus infected cells and their involvement in cellular transformation. Our study will provide important information for using receptors as a therapeutic target against KSHV. 

PEER REVIEWED PUBLICATIONS

1. Bandyopadhyay C, Valiya Veettil M, Dutta S, Chandran B. p130Cas Scaffolds the Signalosome To Direct Adaptor-Effector Cross Talk during Kaposi's Sarcoma-Associated Herpesvirus Trafficking in Human Microvascular Dermal Endothelial Cells. J Virol. 2014 Dec 1;88(23):13858-78.  

2. Valiya Veettil M, Bandyopadhyay C, Dutta D, Chandran B. Interaction of KSHV with Host Cell Surface Receptors and Cell Entry. Viruses. 2014 Oct 23;6(10):4024-4046. Review (Corresponding author).  

3. Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma-Walia N, Dutta S, Chandran B. Glutamate Secretion and Metabotropic Glutamate Receptor 1 Expression during Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Cell Proliferation. PLoS Pathog. 2014 Oct 9;10(10):e1004389 (Corresponding author).

4. Gjyshi O, Bottero V, Valiya Veettil M, Dutta S, Singh VV, Chikoti L, Chandran B. Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 during De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection. PLoS Pathog. 2014 Oct 23;10(10):e1004460.

5. Bandyopadhyay C, Valiya Veettil M, Dutta D, Chakraborty S, Chandran B. CIB1 Synergizes with EphrinA2 to Regulate Kaposi's Sarcoma-Associated Herpesvirus Macropinocytic Entry in Human Microvascular Dermal Endothelial Cells. PLoS Pathogens 2014, 10(2):e 1003941.

6. Dutta S, Bandyopadhyay C, Bottero V, Valiya Veettil M, Wilson L, Michael R. Pins, Karen E. Johnson, Case Warshall and Chandran B. Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration. Molecular Oncology 2014, pii S1574- 7891(13)00 189-026.

7. Sharma-Walia N, Chandran K, Patel K, Valiya Veettil M, and Marginean A. KSHV Induced 5-Lipoxygenase- Leukotriene B4 (5LO/LTB4) Cascade Plays Key Roles In KSHV Latency, Monocyte Recruitment And Lipogenesis. J Virol 2014, 88 (4):2131- 56.

8. Bottero V, Sadagopan S, Johnson KE, Dutta S, Valiya Veettil M, Chandran B. Kaposi's Sarcoma-Associated Herpesvirus-Positive Primary Effusion Lymphoma Tumor Formation in NOD/SCID Mice Is Inhibited by Neomycin and Neamine Blocking Angiogenin's Nuclear Translocation. J Virol, 2013, 87(21):118 06-11820.

9. Dipanjan Dutta, Sayan Chakraborty, Chirosree Bandyopadhyay, Valiya Veettil M, Mairaj Ansari, Vivek Singh, Bala Chandran. EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination. Plos Pathogen (Accepted)

10. Ansari MA, Singh VV, Dutta S, Valiya Veettil M, Dutta D, Chikoti L, Lu J, Everly D, Chandran B. Constitutive Interferon-Inducible Protein 16-Inflammasome Activation During Epstein-Barr Virus Latency I, II and III in B and Epithelial Cells. J Virol. 2013 May 29

11. Chakraborty SValiya Veettil MChandran B. Kaposi's Sarcoma Associated Herpesvirus Entry into Target Cells. Front Microbiol. 2012;3:6. (Review)

12. Sadagopan S*Valiya Veettil M*, Chakraborty S, Sharma-Walia N, Paudel NBottero VChandran B. Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival. Oncogene. 2012 Nov 15;31(46):4835-47. (*Equal authorship).

13. Chakraborty SValiya Veettil MBottero VChandran B. Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infection. Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1163-72

14. Chakraborty S, Valiya Veettil M, Sadagopan S, Paudel N, Chandran B. Lipid rafts form a platform for productive KSHV infection via c-Cbl mediated selective virus-receptor translocations and differential ubiquitination. J Virol. 2011, 85(23):12410-30.

15. Kerur N, Valiya Veettil M, Sharma-Walia N, Bottero V, Sadagopan S, Chandran B. IFI16 acts as a nuclear pathogen sensor and induces inflammasome during Kaposi's sarcoma associated herpesvirus infection of endothelial cells. Cell Host & Microbe, 2011, May 19;9(5):363-75.

16. Sadagopan S, Valiya Veettil M, Paudel N, Bottero V, Chandran B. Kaposi's sarcoma-associated herpesvirus-induced angiogenin plays roles in latency via the phospholipase C{gamma} pathway: Blocking angiogenin inhibits latent gene expression and induces the lytic Cycle. J Virol, 85(6):2666-85, 2011.

17. Valiya Veettil M, Sadagopan S, Kerur N, Chakraborty S, Chandran B. Interaction of c-Cbl with myosin IIA regulates bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus. PLoS Pathog. 6(12),2010. Article ranked in top 2% of papers published in biology and medicine.

18. Kerur N, Valiya Veettil M, Sharma-Walia N, Sadagopan S, Bottero V, George Paul A, Chandran B. Entry and infection of monocytic THP-1 cells by Kaposi’s sarcoma associated herpesvirus: Role of heparan sulfate, DC-SIGN, integrins and signaling. Virology, 2010 ;406(1):103-16, 2010.

19. Sharma-Walia N, George Paul A, Bottero V, Sadagopan S, Valiya Veettil M, Kerur N, and Chandran B. Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: A key factor in latency, inflammation, angiogenesis, cell Survival and invasion. PLoS Pathogens, 6(2), 2010.

20. Raghu H, Sharma-Walia N, Valiya Veettil M, Sadagopan S, Chandran B. Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. Journal of Virology, 83(10):4895-911, 2009.

21. Sadagopan S, Sharma-Walia N, Valiya Veettil M, Raghu H, Bottero V, Levine R, Vart RJ, Chandran B. Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis. Journal of Virology, 83(7):3342-64, 2009.

22. Valiya Veettil M, Sadagopan S, Sharma-Walia N, Wang FZ, Raghu H, Chandran B. Kaposi's sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry stage of infection. Journal of Virology, 82(24):12126-44, 2008.

23. Sivakumar R, Sharma-Walia N, Raghu H, Valiya Veettil M, SadagopanS, Bottero V, Varga L, Levine R, Chandran B.Kaposi's sarcoma associated herpesvirus (KSHV) induces sustained levels of vascular endothelial growth factors -A and -C early during in vitro infection of human microvascular dermal endothelial cells: Biological implications. Journal of Virology, 82(4):1759-1776, 2007.

24. Raghu, H., Sharma-Walia N, Valiya Veettil M, S. Sadagopan, Caballoro A, Sivakumar R, Varga L, Bottero V, Chandran B. Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensable for binding and entry. Journal of Virology, 81(15):7941-7959, 2007.

25. Sadagopan S, Sharma-Walia N, Valiya Veettil M, Raghu H, Sivakumar R, Chandran B. Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. Journal of Virology, 81(8):3949-3968, 2007.

26. Valiya Veettil M, Sharma-Walia N, Sadagopan S, Sivakumar R, Naranatt PP, Chandran B. RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner. Journal of Virology, 80(23):11432-11446, 2006.

27. Sharma Walia N, Raghu H, Sadagopan S, Sivakumar R, Valiya Veettil M, Naranatt PP, Smith M, Chandran B. Cyclooxygenase 2 induced by Kaposi’s sarcoma associated herpesvirus early during infection of target cells plays a role in the maintenance of latent viral gene expression. Journal of Virology, 80 (13):6534-6552, 2006.

28. Valiya Veettil M, Khan R, Paulose CS. Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration. Life Science. 78(14):1603-1609, 2006.

29. Valiya Veettil M, Chathu F, Paulose CS. Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats.Molecular and Cellular Biochemistry, 272(1-2):165-70, 2005.

30. Valiya Veettil M, Kaimal SB, Paulose CS. Decreased 5-HT1A receptor gene expression and 5-HT1A receptor protein in the cerebral cortex and brain stem during pancreatic regeneration in rats. Neurochemical Research. 30(1):25-32, 2005.

UPDATED: 11.20.2014

 

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