Barbara M. Vertel, Ph.D.

Chicago Medical School
Room 3.214
Building: BSB
Phone: 847.578.3443
Fax: 847.578.3253

Selected Publications:

Ebihara, L, Tong, J-J, Vertel, B, White, TW, Chen, T-L (2011) Properties of connexin 46 hemichannels in dissociated lens fiber cells. Invest Ophthalmol Vis Sci. 52: 882-889.

Chen, T-LL, Posey, KL, Hecht, JT, and Vertel, BM (2008)  COMP mutations:  Domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.  J Cell Biochem. 103: 778-787.

Dong, L, Liu, X, Li, H, Vertel, BM, Ebihara, L. (2006)  Role of the N-terminus in permeability of chicken connexin 45.6 gap junctional channels. J Physiol. 576: 787-799.
Zhao, W, Chen, T-LL, Vertel, BM, and Colley, KJ  (2006) The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxy-terminal cytoplasmic tail. J Biol Chem. 281: 31106-31118.

Fu, L, Gao, Y, Tousson, A, Shah, A, Chen, T-LL, Vertel, BM, and Sztul, E (2005)  Nuclear aggresomes form by fusion of PML-associated aggregates. Molec Biol Cell 16: 4905-4917.

Chen, T-LL, Stevens, JW, Hecht, JT, and Vertel, BM (2004)  Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH. Matrix Biology 23:  433-444.

Chen, T-LL, Chen, C, Bergeron, NQ, Close, BE, Bohrer, TJ, Vertel, BM, and Colley, KJ (2003)  The two rat a2,6-Sialyltransferase (ST6Gal I) isoforms:  Evaluation of catalytic activity and intra-Golgi localization.  Glycobiology 13: 109-117.

Chen, T-LL, Wang, PY, Luo, W, Gwon, S, Flay, NW, Zheng, J, Guo, C, Tanzer, ML, and Vertel, BM (2001)  Aggrecan domains expected to traffic through the exocytic pathway are misdirected to the nucleus.  Exp Cell Res. 263: 224-235.

Hecht, JT, Deere, M, Putnam, E, Cole, W, Vertel, BM, Chen, H, Lawler, J (1998) Characterization of Cartilage Oligomeric Matrix Protein (COMP) in human normal and Pseudoachondroplasia musculoskeletal tissues. Matrix Biol. 17: 269-278.

Vertel, BM (1995) The ins and outs of aggrecan. Trends in Cell Biol. 5: 458-464.

Domowicz, M, Li, H, Hennig, A, Henry, J, Vertel, BM and Schwartz, NB (1995) The biochemically and immunologically distinct CSPG of notochord is a product of the aggrecan gene. Develop Biol. 171: 655-664.

Vertel, BM, Grier, BL., Li, H and Schwartz, NB (1994) The chondrodystrophy, Nanomelia: Biosynthesis and processing of the defective aggrecan precursor. Biochem J. 301: 211-216.

Vertel, BM, Walters, LM, Grier, B, Maine, N and Goetinck, PF (1993) Nanomelic chondrocytes synthesize, but fail to translocate, a truncated aggrecan precursor. J Cell Sci. 104: 939-948.

Vertel, BM, Walters, LM, Flay, N, Kearns, AE, and Schwartz, NB (1993) Xylosylation is an ER to Golgi event. J Biol Chem. 268: 11105-11112.

Kearns, AE, Vertel, BM, and Schwartz, NB (1993) Topography of glycosylation and UDP-xylose production. J Biol Chem. 268: 11097-11104.

Li, H., Schwartz, N.B. and Vertel, BM (1993) cDNA Cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, Nanomelia. J Biol Chem. 268: 23504-23511.

Vertel, BM, Walters, LM, Mills, D (1992). Subcompartments of the endoplasmic reticulum. Seminars in Cell Biol. 3: 325-341.

Montgomery, RI, Vertel, BM, Liang, J, Flay, NW, Lidholt, K, Lindahl, U, and Esko, J (1992) Stable heparin-producing cell lines derived from the Furth murine mastocytoma Proc Natl Acad Sci. USA 89: 11327-11331. 

Vertel, BM, Velasco, A, LaFrance, S, Walters, L and Kaczman-Daniel, K  (1989) Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum. J Cell Biol. 109: 1827-1836.



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