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Barbara M. Vertel, Ph.D.

Chicago Medical School
Room 3.214
Building: BSB
Phone: 847.578.3443
Fax: 847.578.3253

Selected Publications:

Veditti, R, Scanu, T, Santoro, M, Di Tullio, G, Spaar, A, Gaibisso, R, Beznoussenko, GV, Mironov, AA, Mironov Jr, A, Zelante, L, Piemotese, MR, Notorangelo, A, Malhotra, V, Vertel, BM, Wilson, C, De Matteis, MA (2012). Sedlin controls the ER export of procollagen by regulating the Sar1 cycle. Science 337, 1668-1672.

Tong, J-J, Sohn, BCH, Lam, A, Walters, DE, Vertel, BM, Ebihara, L (2013).  Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46. Am J Physiol Cell Physiol. 304, C823-32.

Ebihara, L, Tong, J-J, Vertel, B, White, TW, Chen, T-L (2011) Properties of connexin 46 hemichannels in dissociated lens fiber cells. Invest Ophthalmol Vis Sci. 52: 882-889.

Chen, T-LL, Posey, KL, Hecht, JT, and Vertel, BM (2008)  COMP mutations:  Domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.  J Cell Biochem. 103: 778-787.

Dong, L, Liu, X, Li, H, Vertel, BM, Ebihara, L. (2006)  Role of the N-terminus in permeability of chicken connexin 45.6 gap junctional channels. J Physiol. 576: 787-799.
Zhao, W, Chen, T-LL, Vertel, BM, and Colley, KJ  (2006) The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxy-terminal cytoplasmic tail. J Biol Chem. 281: 31106-31118.

Fu, L, Gao, Y, Tousson, A, Shah, A, Chen, T-LL, Vertel, BM, and Sztul, E (2005)  Nuclear aggresomes form by fusion of PML-associated aggregates. Molec Biol Cell 16: 4905-4917.

Chen, T-LL, Stevens, JW, Hecht, JT, and Vertel, BM (2004)  Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH. Matrix Biology 23:  433-444.

Chen, T-LL, Chen, C, Bergeron, NQ, Close, BE, Bohrer, TJ, Vertel, BM, and Colley, KJ (2003)  The two rat a2,6-Sialyltransferase (ST6Gal I) isoforms:  Evaluation of catalytic activity and intra-Golgi localization.  Glycobiology 13: 109-117.

Chen, T-LL, Wang, PY, Luo, W, Gwon, S, Flay, NW, Zheng, J, Guo, C, Tanzer, ML, and Vertel, BM (2001)  Aggrecan domains expected to traffic through the exocytic pathway are misdirected to the nucleus.  Exp Cell Res. 263: 224-235.

Hecht, JT, Deere, M, Putnam, E, Cole, W, Vertel, BM, Chen, H, Lawler, J (1998) Characterization of Cartilage Oligomeric Matrix Protein (COMP) in human normal and Pseudoachondroplasia musculoskeletal tissues. Matrix Biol. 17: 269-278.

Vertel, BM (1995) The ins and outs of aggrecan. Trends in Cell Biol. 5: 458-464.

Domowicz, M, Li, H, Hennig, A, Henry, J, Vertel, BM and Schwartz, NB (1995) The biochemically and immunologically distinct CSPG of notochord is a product of the aggrecan gene. Develop Biol. 171: 655-664.

Vertel, BM, Grier, BL., Li, H and Schwartz, NB (1994) The chondrodystrophy, Nanomelia: Biosynthesis and processing of the defective aggrecan precursor. Biochem J. 301: 211-216.

Vertel, BM, Walters, LM, Grier, B, Maine, N and Goetinck, PF (1993) Nanomelic chondrocytes synthesize, but fail to translocate, a truncated aggrecan precursor. J Cell Sci. 104: 939-948.

Vertel, BM, Walters, LM, Flay, N, Kearns, AE, and Schwartz, NB (1993) Xylosylation is an ER to Golgi event. J Biol Chem. 268: 11105-11112.

Kearns, AE, Vertel, BM, and Schwartz, NB (1993) Topography of glycosylation and UDP-xylose production. J Biol Chem. 268: 11097-11104.

Li, H., Schwartz, N.B. and Vertel, BM (1993) cDNA Cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, Nanomelia. J Biol Chem. 268: 23504-23511.

Vertel, BM, Walters, LM, Mills, D (1992). Subcompartments of the endoplasmic reticulum. Seminars in Cell Biol. 3: 325-341.

Montgomery, RI, Vertel, BM, Liang, J, Flay, NW, Lidholt, K, Lindahl, U, and Esko, J (1992) Stable heparin-producing cell lines derived from the Furth murine mastocytoma Proc Natl Acad Sci. USA 89: 11327-11331. 

Vertel, BM, Velasco, A, LaFrance, S, Walters, L and Kaczman-Daniel, K  (1989) Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum. J Cell Biol. 109: 1827-1836.



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