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Carl White, Ph.D.

Assistant Professor, Physiology and Biophysics

Chicago Medical School
Building: RLE-3.345
Phone: 847-578-8358
Fax: 847-578-3265

Recent Publications

Kang, D., Wang, J., Hogan, J. O., Vennekens, R., Freichel, M., White, C., and Kim, D. (2014) Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body. Journal of Physiology (in press) [PubMed]

Nixon, A., Jia, Y., White, C., and Bradbury, N. A. (2013) Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection. American Journal of Physiology (Cell Physiol), 304, C164–9 [PubMed]

Huang, H., Hu, X., Eno, C. O., Zhao, G., Li, C., and White, C. (2013) An Interaction between Bcl-xL and VDAC Promotes Mitochondrial Ca2+ Uptake. Journal of Biological Chemistry, 288, 19870–81 [PubMed]

Velmurugan, G. V, Sundaresan, N. R., Gupta, M. P., and White, C. (2013) Defective Nrf2-dependent redox signaling contributes to microvascular dysfunction in type 2 diabetes. Cardiovascular Research 100, 143–50. [PubMed]

·         Featured in the Editorial: Reducing damage through Nrf-2.  Balligand, J.-L. (2013) Cardiovasc. Res. 100, 1–3

Velmurugan, G.V. and C. White (2012) Calcium Homeostasis in Vascular Smooth Muscle Cells is altered in Type 2 Diabetes by Bcl-2 Protein Modulation of InsP3R Calcium Release Channels. American Journal of Physiology (Heart Circ Physiol), 302(1), H124-H134  [PubMed]

Eno, C. O., Eckenrode, E. F., Olberding, K. E., Zhao, G., White, C., and Li, C. (2012) Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis. Molecular Biology of the Cell 23, 2605–18 [PubMed]

Bozym, R.A., Patel, K., White, C., Cheung, K-H., Bergelson, J.M., Morosky, S.A. and C.B. Coyne (2011) Calcium signals and Calpain-dependent Necrosis are essential for Release of Coxsackievirus B from Polarized Intestinal Epithelial Cells. Molecular Biology of the Cell, 22(17), 3010-21. [PubMed]

Wang, X., Olberding, K.E., White, C. and C. Li (2011) Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis. Cell Death & Differentiation, 18,38-47. [PubMed]

Paul, A.G., Sharma-Walia, N., Kerur, N., White, C. and B. Chandran (2010) Piracy of Prostaglandin E2/EP Receptor–Mediated Signaling by Kaposi's Sarcoma-Associated Herpes Virus (HHV-8) for Latency Gene Expression: Strategy of a Successful Pathogen. Cancer Research. 70(9), 3697- 3708. [PubMed]

Eckenrode, E.F., Yang, J., Velmurugan,G.V., Foskett, J.K. and C. White (2010) Apoptosis Protection by Mcl-1 and Bcl-2 Modulation of Inositol 1,4,5-Trisphosphate Receptor-dependent Ca2+ Signaling. Journal of Biological Chemistry. 285(18), 13678-13684. [PubMed]

Ionescu, L., White, C., Cheung, K-H., Shuai, J., Parker, I., Pearson, J.E., Foskett, J.K. and D-O.D. Mak (2007) Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels. Journal of General Physiology, 130(6): 631-45. [PubMed]

Li, C., Wang, X., Vais, H., Thompson, C.B., Foskett, J.K. and C. White (2007). Apoptosis regulation by Bcl-xL modulation of mammalian InsP3R channel isoform gating. PNAS, 104(30), 12565-70. [PubMed]

Jones, R.G., Bui, T., White, C., Madesh, M., Krawczyk, C.M., Frauwirth, K.A., Kubek, S., Wang, L.Y., Hawkins, B.J., Lindsten, T., Conway, S., Roderick, H.L., Bootman, M.D., Shen, H., Foskett, J.K. and C. B. Thompson. (2007). Bax and Bak regulate T cell proliferation through control of ER Ca2+ homeostasis. Immunity, 27(2),268-280. [PubMed]

·         Featured in the Editorial: Playing on Both Sides of the Field. Sci. STKE 2007 (401), tw308.

Mak, D.-O.D., White, C., Ionescu, L. and J.K. Foskett (2007). The inositol trisphosphate receptor Ca2+ release channel. Physiological Reviews. 87(2),5923- 658. [PubMed]

White, C., Yang, J., Monteiro, M.J. and J.K. Foskett (2006). CIB1, a ubiquitously-expressed Ca2+-binding protein-ligand of the InsP3 receptor Ca2+-release channel. Journal of Biological Chemistry, 281(30),20825-20833 [PubMed]

·         Featured in the Editorial: New Ligand for IP3 Receptors? Sci. STKE 2006 (346), tw259.

Ionescu, L., Cheung, K.H., Vais, H., Mak, D-O.D., White, C. and J.K. Foskett (2006). Graded recruitment and inactivation of single InsP3 receptor Ca2+ channels. Journal of Physiology, 573, 645-662. [PubMed]

White, C., Chi, L., Yang, J., Petrenko, N., Muniswamy, M., Thompson, C.B. and J. K. Foskett (2005). The endoplasmic reticulum gateway to apoptosis: Bcl-XL modulation of the InsP3 receptor. Nature Cell Biology, 7,1021-1028. [PubMed]

Mak, D-O.D., White, C., Ionescu, L. and J.K. Foskett (2005). Nuclear patch clamp electrophysiology of inositol trisphosphate receptor Ca2+ release channels. In Putney, J.W., Jr.(ed), Calcium Signaling, 2nd Ed. CRC Press, Boca Raton.

Kumar D, White C, Fairweather I,and J.G. McGeown (2004). Electrophysiological and pharmacological characterization of K+-currents in muscle fibres isolated from the ventral sucker of Fasciola hepatica. Parasitology, 129,779-93. [PubMed]

White, C. and J. G. McGeown (2003). Inositol 1,4,5-trisphosphate receptors modulate Ca2+-sparks and Ca2+-store content in vas deferens myocytes. American Journal of Physiology (Cell Physiol), 285(1),C195-204. [PubMed]

White, C. and J. G. McGeown (2002). Carbachol triggers RyR-dependent Ca2+ release via activation of IP3 receptors in isolated rat gastric myocytes. Journal of Physiology, 542,725-733. [PubMed]

White, C. and J. G. McGeown (2002). Imaging of changes in sarcoplasmic reticulum [Ca2+] using Oregon Green BAPTA 5N and confocal laser scanning microscopy. Cell Calcium, 31,151-159. [PubMed]

White, C. and J. G. McGeown (2000). Ca2+ uptake by the sarcoplasmic reticulum decreases the amplitude of depolarization-dependent [Ca2+]i transients in rat gastric myocytes. Pflűgers Archiv-European Journal of Physiology, 440, 488-495. [PubMed]

White, C. and J. G. McGeown (2000). Regulation of basal intracellular calcium concentration by the sarcoplasmic reticulum in myocytes from the rat gastric antrum. Journal of Physiology, 529,395-404. [PubMed]